Nanoparticles integrating natural and synthetic polymers for <i>in vivo</i> insulin delivery

Hadiya, Safy; Radwan, Radwa; Zakaria, Menna; El-Sherif, Tahra; Hamad, Mostafa A.; Elsabahy, Mahmoud

doi:10.1080/10837450.2020.1832117

Cited by 17 publications

(7 citation statements)

References 59 publications

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“…The NPs were well-tolerated after oral administration in rats, as evidenced by measuring the level of alanine aminotransferase, aspartate aminotransferases, albumin, creatinine, and urea. This study indicated that the features and delivery efficiency of nanomaterials could be controlled by utilizing several natural/synthetic polymers and by fine-tuning the combination ratios between polymers [89].…”

Section: Polymeric Nanoparticlesmentioning

confidence: 92%

Emerging Treatment Strategies for Diabetes Mellitus and Associated Complications: An Update

et al. 2021

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The occurrence of diabetes mellitus (DM) is increasing rapidly at an accelerating rate worldwide. The status of diabetes has changed over the last three generations; whereas before it was deemed a minor disease of older people but currently it is now one of the leading causes of morbidity and mortality among middle-aged and young people. High blood glucose-mediated functional loss, insulin sensitivity, and insulin deficiency lead to chronic disorders such as Type 1 and Type 2 DM. Traditional treatments of DM, such as insulin sensitization and insulin secretion cause undesirable side effects, leading to patient incompliance and lack of treatment. Nanotechnology in diabetes studies has encouraged the development of new modalities for measuring glucose and supplying insulin that hold the potential to improve the quality of life of diabetics. Other therapies, such as β-cells regeneration and gene therapy, in addition to insulin and oral hypoglycemic drugs, are currently used to control diabetes. The present review highlights the nanocarrier-based drug delivery systems and emerging treatment strategies of DM.

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Section: Polymeric Nanoparticlesmentioning

confidence: 92%

Emerging Treatment Strategies for Diabetes Mellitus and Associated Complications: An Update

et al. 2021

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“…A nanostructured carrier is a pore-containing microcapsule, suitable for the delivery of small molecules including insulin, glucose, and oxygen, as well as other bulky components of the immune system including virus particles and immunoglobulins. 31 Polymers are the most well-studied nanomaterials used for the delivery of insulin. Hydrophobic and hydrophilic polymers are often used for the synthesis of nanoparticles and microparticles.…”

Section: Novel Strategies For Insulin Nano Deliverymentioning

confidence: 99%

“…Advances in nanotechnology and drug delivery via nanostructured carriers have introduced novel therapeutic options in the DM therapy. A nanostructured carrier is a pore‐containing microcapsule, suitable for the delivery of small molecules including insulin, glucose, and oxygen, as well as other bulky components of the immune system including virus particles and immunoglobulins 31 . Polymers are the most well‐studied nanomaterials used for the delivery of insulin.…”

Section: Novel Strategies For Insulin Nano Deliverymentioning

confidence: 99%

Bile acid‐based advanced drug delivery systems, bilosomes and micelles as novel carriers for therapeutics

Nemati

Azarbayjani

Al‐Salami

et al. 2022

Cell Biochemistry & Function

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Diabetes mellitus affects almost half a billion patients worldwide and results from either destruction of β‐cells responsible for insulin secretion or increased tissue resistance to insulin stimulation and the reduction of glycemic control. Novel drug delivery systems can improve treatment efficacy in diabetic patients. The low aqueous solubility of most oral antidiabetic drugs decreases drug bioavailability; therefore, there is a demand for the use of novel methods to overcome this issue. The application of bile acids mixed micelles and bilosomes can provide an enhancement in drug efficacy. Bile acids are amphiphilic steroidal molecules that contain a saturated tetracyclic hydrocarbon cyclopentanoperhydrophenanthrene ring, and consist of three 6‐membered rings and a 5‐membered ring, a short aliphatic side chain, and a tough steroid nucleus. This review offers a comprehensive and informative data focusing on the great potential of bile acid, their salts, and their derivatives for the development of new antidiabetic drug delivery system.

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“…It is noteworthy that all the unique features of Alg-NPs can be easily tuned by combining alginate with other synthetic or natural polymers (e.g., poly(vinyl alcohol) (PVA), chitosan, pectin, etc.). [137] For instance, alginate-based NPs coated with a shell of starch and cellulose were explored for the delivery of calcitonin drug and/or Amaranthus retroflexcus L. extract in bone regeneration applications. [138] Noticeably, in vitro release studies in simulated body fluid and phosphate-buffered saline (PBS) showed the superior performances of the natural extract with respect to the industrial compound.…”

Section: Chitosanmentioning

confidence: 99%

An Up‐to‐Date Review on Alginate Nanoparticles and Nanofibers for Biomedical and Pharmaceutical Applications

Dodero

Alberti

Gaggero

et al. 2021

Adv Materials Inter

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along with other polysaccharides (e.g., celluloses, chitosan, etc.), is indeed considered an extremely promising material in the viewpoint of circular economy and in substituting petroleum-derived polymers. [3] Among others, one of the reasons for alginate success is its unique capability to bind different cations leading to stable and tailor-made hydrogels. [4] Owing to its biocompatibility, biodegradability, and nontoxicity, in the past decades alginate has been vastly explored for drug and gene delivery, tissue engineering, and wound healing applications. [5] In this sense, the recent nanotechnological advances have allowed the fabrication and exploitation of alginate-based nanostructured materials with completely new capabilities. Thereby, it is not surprising that nowadays a broad variety of alginate-based nanomaterials with various shapes, sizes, and compositions are prepared via different approaches, including controlled gelation, electrospinning and electrospraying, self-assembly, phase-separation, and micro fluidics., All these nanostructures hold the potential to interact with living organisms much more efficiently with respect to bulk systems, hence leading to specific functionalities at the same time avoiding the occurrence of toxicity issues. [6][7][8] Despite the use of alginate-based nanomaterials has been reviewed in the past, the focus has been commonly pointed to their generic properties and applications. Conversely, this review attempts to provide a more specific and comprehensive summary limited to the most recent advances in the fabrication and use of two of the most common and promising alginatebased nanomaterials, namely nanoparticles (NPs) and electrospun nanofibers (NFs), with a focus on biomedical and pharmaceutical applications.

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Nanoparticles integrating natural and synthetic polymers for in vivo insulin delivery

Cited by 17 publications

References 59 publications

Emerging Treatment Strategies for Diabetes Mellitus and Associated Complications: An Update

Emerging Treatment Strategies for Diabetes Mellitus and Associated Complications: An Update

Bile acid‐based advanced drug delivery systems, bilosomes and micelles as novel carriers for therapeutics

An Up‐to‐Date Review on Alginate Nanoparticles and Nanofibers for Biomedical and Pharmaceutical Applications

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