Nanoparticles Isolated From Porcine Bone Soup Ameliorated Dextran Sulfate Sodium-Induced Colitis and Regulated Gut Microbiota in Mice

Abstract

Daily foods contain a great number of self-assembled nanoparticles (NPs) which were incidentally produced during food processing. These food incidental NPs can directly access the human gastrointestinal tract in high frequency and large quantities. Limited reports were focused on whether and how these food incidental NPs affected the gastrointestinal tissues and gut microbiota. In the present study, bone soup and its NPs both significantly ameliorated colitis symptoms in dextran sulfate sodium (DSS)-induced mice and inhibited the release of pro-inflammatory cytokines. They also restored intestinal microbiota dysbiosis by improving the diversity and richness of intestinal microbiota and regulating community composition, such as a remarkable increase in Muribaculaceae, Alistipes, and Alloprevotella, and a decrease in Helicobacter. Moreover, the correlation analysis showed that pro-inflammatory cytokines were negatively correlated with Muribaculaceae, Alloprevotella, and Alistipes, but positively correlated with Helicobacter. These findings suggest that the food incidental NPs can influence human health through regulating the inflammation of the gastrointestinal tissues and the gut microbiota.

Cassane diterpenoid ameliorates dextran sulfate sodium-induced experimental colitis by regulating gut microbiota and suppressing tryptophan metabolism

“…The family Prevotellaceae and the genus Alloprevotella were relatively enriched in CAip group. Consistent with our results, the genus Alloprevotella was demonstrated to be lower in DSS-induced experimental colitis, which was generally considered to be short chain fatty acid producer and its abundance was inversely correlated with inflammation ( 45 , 46 ). Collectively, the alleviative effects of CA on the experimental colitis might be attributed to its gut microbiota modulation activity.…”

Dietary Turmeric Consumption Alleviates Ulcerative Colitis via Restoring Tryptophan Metabolism and Alleviating Gut Microbiota Dysbiosis in Mice

“…At the genus level, after supplementation of TP, the abundance of Muribaculaceae, Ileibacterium, Lactobacillus, Alloprevotella, and Bifidobacterium was notably elevated and the abundance of Lachnospiraceae was decreased in UC mice; it has been reported that most of these bacteria in UC patients were significantly disturbed . In addition, Muribaculaceae and Bifidobacterium were demonstrated to be potentially beneficial for relieving inflammation and facilitating immunocompetence in colitis mice Ileibacterium and Alloprevotella, the groups of bacteria associated with SCFAs, have been proved to modulate systemic inflammation .…”

“…38 In addition, Muribaculaceae and Bifidobacterium were demonstrated to be potentially beneficial for relieving inflammation and facilitating immunocompetence in colitis mice. 39 Ileibacterium and Alloprevotella, the groups of bacteria associated with SCFAs, have been proved to modulate systemic inflammation. 40 Similarly, our results indicated that the cecal contents of SCFAs were elevated by the intake of TP in UC mice.…”

Anti-inflammatory probiotics HF05 and HF06 synergistically alleviate ulcerative colitis and secondary liver injury

“…Lactobacillus has the potential to alleviate inflammation and enhance immune function in mice suffering from DSS-induced colitis. 59,60 In the DSS group, there was a significant decrease in the abundance of Lactobacillus , whereas intervention with HF06, HF05, and MIXL resulted in a significant increase in Lactobacillus levels. Notably, MIXL exhibited a more pronounced effect in increasing the abundance of Lactobacillus compared to HF06 and HF05.…”