Nanoparticles labeled with gamma-emitting radioisotopes: an attractive approach for in vivo tracking using SPECT imaging

Ahmadi, Mahnaz; Emzhik, Marjan; Mosayebnia, Mona

doi:10.1007/s13346-023-01291-1

Cited by 6 publications

(3 citation statements)

References 238 publications

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“…Radionuclides are unstable isotopes that emit radiation primarily through radioactive decay, including alpha (α) particles, charged beta particles (positrons, β+; electrons, β−), gamma (γ) rays, or electron (e) radiation. 982 Researchers combine these radionuclides with biologically relevant molecules to develop radiopharmaceuticals, which are then applied to visualize organs or identify infected tissues. 983 Depending on the specific decay processes of radionuclides, two primary nuclear imaging modalities have been developed: single-photon emission computed tomography (SPECT) and positron emission tomography (PET).…”

Section: Theranosticsmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

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Polymeric Nanoparticles for Drug Delivery

Beach,

Nayanathara,

Gao

et al. 2024

Chem. Rev.

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The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated the creation of more sophisticated drug delivery systems. Polymeric nanoparticles sit at the forefront of numerous promising drug delivery designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, and surface functionality. Furthermore, polymeric nanoparticles have the ability to navigate various biological barriers to precisely target specific sites within the body, encapsulate a diverse range of therapeutic cargo and efficiently release this cargo in response to internal and external stimuli. However, despite these remarkable advantages, the presence of polymeric nanoparticles in wider clinical application is minimal. This review will provide a comprehensive understanding of polymeric nanoparticles as drug delivery vehicles. The biological barriers affecting drug delivery will be outlined first, followed by a comprehensive description of the various nanoparticle designs and preparation methods, beginning with the polymers on which they are based. The review will meticulously explore the current performance of polymeric nanoparticles against a myriad of diseases including cancer, viral and bacterial infections, before finally evaluating the advantages and crucial challenges that will determine their wider clinical potential in the decades to come.

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Section: Theranosticsmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Polymeric Nanoparticles for Drug Delivery

Beach,

Nayanathara,

Gao

et al. 2024

Chem. Rev.

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“…Radiolabeled tracing techniques, utilizing radioactive isotopes to label nanoparticles or drugs, offer distinct advantages over other methods for studying blood pharmacokinetics: (1) high sensitivity: radiolabeled tracing techniques, such as PET or SPECT, provide high sensitivity for detecting and quantifying radiolabeled nanoparticle distribution, even at low concentrations [13,14]; (2) real-time whole-body imaging: these techniques offer real-time, comprehensive insights into nanoparticle biodistribution throughout the organism, aiding in understanding systemic distribution patterns and potential off-target effects [15,16]; (3) noninvasiveness: radiolabeled tracing techniques eliminate the need for invasive procedures such as blood sampling or tissue biopsies, making them ideal for longitudinal studies [17]; (4) quantitative measurements: calibration standards and tracer kinetics models enable accurate determination of radiolabeled nanoparticle concentrations at different time points and in various tissues [18]; and (5) translational potential: these techniques are commonly used in clinical settings, facilitating the translation of nanomedicine research into clinical practice by providing data on safety, biodistribution, and efficacy in humans [19]. While radiolabeled tracing techniques offer significant advantages, it is essential to consider potential radiation exposure and adhere to safety guidelines to minimize risks to researchers and study participants.…”

Section: Introductionmentioning

confidence: 99%

Radiolabeled Tracing Techniques Illuminating Blood Pharmacokinetics in Nanomedicine

Zhou,

Zhang,

Wang

et al. 2024

Nano Biomedicine and Engineering

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In the realm of pharmaceutical advancement, the transformative prowess of nanotechnology shines through its precision-targeted drug delivery and amplified therapeutic effects. This paper ventures into the realm of radiolabeling techniques for unraveling the intricate choreography of drug kinetics within the bloodstream which encompass the delicate stages of absorption, distribution, metabolism, and excretion. Through the magical lens of the radiolabel, a real-time spectacle unfolds, providing invaluable insights into the safety and efficacy of nanomedicine interventions. Amid the labyrinthine complexities of drug-organism interactions and the lack of universal protocols for nanomedicine preparation, radiolabeling technology has emerged as a guiding constellation. The paper systematically assesses the methods commonly employed for pharmacokinetic studies, delves into the manifold advantages and techniques of radiolabel methods within the nanomedicine landscape, closely examines their application across a spectrum of pharmacokinetic studies and thoughtfully addresses the challenges they may pose. Embark on this illuminating odyssey-a journey that peers into the microcosm of nanomedicine, deciphering its dynamic interplay within the bloodstream through the luminary insights of radiolabeled tracing techniques.

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