Nanoparticles-mediated ion channels manipulation: From their membrane interactions to bioapplications

Huang, Qiwen; Zhu, Weisheng; Gao, Xiaoyin; Liu, Xing‐Ping; Zhang, Zhijun; Xing, Bengang

doi:10.1016/j.addr.2023.114763

Cited by 20 publications

(10 citation statements)

References 234 publications

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“…This is based on the fact that some ion channel are sensitive to temperature and can be activated by the heat generated from external stimuli ( Figure ). [ 45 ] For instance, TRPV1 protein has an activation temperature of 42 °C, which is close to the normal body temperature and can be rapidly activated. It can also close the channel normally to provide a signal to avoid harmful high temperatures.…”

Section: Regulation Modes Of Ion Channel By Nir‐responsive Nanomaterialsmentioning

confidence: 99%

Near‐Infrared Responsive Nanomaterials for the Regulation of Ion Channel Function

Li,

Gao,

et al. 2023

Macro Chemistry & Physics

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Ion channel are responsible for the propagation and integration of electrical signals in physiological processes. Over‐activation or dysfunction of ion channel plays an important role in physiological and pathological processes and is an important research object for disease treatment. With the widespread application of optical technologies of near infrared (NIR) light responsive materials, the precise regulation of biological processes through optical control, featuring non‐invasive, remote control, and high flexibility, has penetrated the physiological processes. In recent years, an increasing number of light‐stimulated materials have been developed and utilized, with stable properties, easy modification, and sensitive response, enabling precise control of biological processes at the forefront of biomedical research. This review summarizes NIR responsive materials in ion channel regulation and elucidates their action mechanism in regulating ion channel‐related diseases. It is hoped that this review can provide foundation of research for future light‐stimulated materials, promote the application of light‐stimulated materials in biomedical engineering, and be useful for clinical disease treatment.This article is protected by copyright. All rights reserved

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Section: Regulation Modes Of Ion Channel By Nir‐responsive Nanomaterialsmentioning

confidence: 99%

Near‐Infrared Responsive Nanomaterials for the Regulation of Ion Channel Function

Li,

Gao,

et al. 2023

Macro Chemistry & Physics

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“…Modulating the bioelectric state of these cells by altering ion concentrations in their environment using bioelectronics can signi cantly affect their growth and proliferation 13 . For instance, Tumor Treating Fields (TTFs) use high-frequency alternating current (AC) electric elds to disrupt cell division 14 .…”

Section: Introductionmentioning

confidence: 99%

Directing cancer cell fate with wireless barium titanate@PEDOT nanoparticles to control bioelectricity

Jones,

Carvalho,

Jain

et al. 2024

Preprint

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Cancer cells exhibit unique bioelectrical properties, yet therapeutic strategies exploiting these are still lacking. Herein, we merge a nanobioelectronic system comprising of a barium titanate nanoparticle core and a poly(3,4-ethylenedioxythiophene) shell (BTO@PEDOT NPs) with cancer cells to modulate bioelectricity. We hypothesize that the BTO@PEDOT NPs act as a nanoantenna, transducing a mechanical input provided by external ultrasound (US) stimulation into an electrical output, capable of interfering with the bioelectronic circuitry of the human breast cancer cell lines, MCF-7 and MDA-MB-231. Upon US stimulation the viability of MCF-7 and MDA-MB-231 treated with 200 µg mL-1 BTO@PEDOT NPs reduced significantly to 31% and 24%, respectively, while healthy human mammary fibroblasts were unaffected by the treatment (94% viability). The treatment increased ROS levels and intracellular Ca2+ concentrations, thus promoting apoptosis. These findings underscore the potential of nanobioelectronic systems as an emerging and promising strategy for cancer intervention with no impact on healthy cells.

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“…Transmembrane channels play a crucial role in myriad biological events, including regulating membrane potentials, virus entry into host cells, intercellular communications, electrical signaling, and neuronal dysfunction, via precisely controlled directional flow of ions 1 – 4 . The permeability of transmembrane channels can change swiftly under external stimuli, thus enabling the stimuli-responsive control of the transport properties of biological transmembrane channels 5 – 8 .…”

Section: Introductionmentioning

confidence: 99%

Rectifying artificial nanochannels with multiple interconvertible permeability states

Qian,

Wu,

Yang

et al. 2024

Nat Commun

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Transmembrane channels play a vital role in regulating the permeation process, and have inspired recent development of biomimetic channels. Herein, we report a class of artificial biomimetic nanochannels based on DNAzyme-functionalized glass nanopipettes to realize delicate control of channel permeability, whereby the surface wettability and charge can be tuned by metal ions and DNAzyme-substrates, allowing reversible conversion between different permeability states. We demonstrate that the nanochannels can be reversibly switched between four different permeability states showing distinct permeability to various functional molecules. By embedding the artificial nanochannels into the plasma membrane of single living cells, we achieve selective transport of dye molecules across the cell membrane. Finally, we report on the advanced functions including gene silencing of miR-21 in single cancer cells and selective transport of Ca2+ into single PC-12 cells. In this work, we provide a versatile tool for the design of rectifying artificial nanochannels with on-demand functions.

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Nanoparticles-mediated ion channels manipulation: From their membrane interactions to bioapplications

Cited by 20 publications

References 234 publications

Near‐Infrared Responsive Nanomaterials for the Regulation of Ion Channel Function

Near‐Infrared Responsive Nanomaterials for the Regulation of Ion Channel Function

Directing cancer cell fate with wireless barium titanate@PEDOT nanoparticles to control bioelectricity

Rectifying artificial nanochannels with multiple interconvertible permeability states

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