Nanoparticles of 2-deoxy-d-glucose functionalized poly(ethylene glycol)-co-poly(trimethylene carbonate) for dual-targeted drug delivery in glioma treatment

Jiang, Xinyi; Xin, Hongliang; Ren, Qiuyue; Gu, Jijin; Zhu, Lingjun; Du, F.; Feng, Chunlai; Xie, Yike; Sha, Xianyi; Fang, Xiaoling

doi:10.1016/j.biomaterials.2013.09.094

Cited by 232 publications

(169 citation statements)

References 35 publications

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“…After intravenous administration at a dose of 100 mg/kg blank DGlueNP per day for a week, acute toxicity to hematological system, liver, kidney, heart, lung and spleen in mice, in initial safety tests, was not shown. In comparison with nonglucosylated nanoparticles (NP), a significantly higher amount of DGlueNP was internalized by RG-2 glioma cells through caveolae-mediated and clathrin-mediated endocytosis [30].…”

Section: Nanoparticles For Therapy Breast Cancermentioning

confidence: 99%

Breast cancer: early diagnosis and effective treatment by drug delivery tracing

Shamsi

Islamian

2017

Nucl. Med. Rev.

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Breast cancer is the most frequent cancer in women and it is the main reason of cancer-related deaths of women worldwide.Different types of breast cancer diagnostic examinations are also available, such as mammography, MRI, biopsy, ultrasound and molecular imaging. Radionuclide-based imaging methods including SPECT and PET are useful in early diagnosis and treatment of the cancer. The radiolabeling of chemo drugs with nanoparticles should be recommended from the standpoint of an early diagnosis and effective treatment of breast cancer.

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Section: Nanoparticles For Therapy Breast Cancermentioning

confidence: 99%

Breast cancer: early diagnosis and effective treatment by drug delivery tracing

Shamsi

Islamian

2017

Nucl. Med. Rev.

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“…The peptide angiopep-2 has also been attached onto the surface of several nanomedicines to target LRP1 [69,70]. Furthermore, glucose or mannose conjugation to nanomedicines has conferred brain-targeting properties through overexpressed facilitative glucose transporters [71,72].…”

Section: Systemic Delivery Of Nanomedicinesmentioning

confidence: 99%

Managing CNS Tumors: The Nanomedicine Approach

Aparicio-Blanco¹,

Torres-Suárez²

2017

New Approaches to the Management of Primary and Secondary CNS Tumors

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Albeit the rapidly evolving knowledge about tumor biochemistry enables various new drug molecules to be designed as treatments, malignant central nervous system (CNS) tumors remain untreatable due to the failure to expose the entire tumor to such therapeutics at pharmacologically meaningful quantities. Therefore, drug delivery in CNS tumors must be properly addressed, as otherwise, novel therapies will continue to fail. In this regard, nanomedicine poses an appealing platform for efficient drug delivery to the CNS, since it may be targeted to improve the drug availability in the site of action, which would be translated into lower drug doses and fewer side effects. Hence, the accumulation of data about the CNS physiology and their relevant receptors, the widening therapeutic armamentarium of drugs potentially useful in CNS chemotherapy and the alternative routes for administration may envisage nanomedicines as a forthcoming routine approach. Indeed, on the basis of the promising results gathered from preclinical studies of nanomedicine-based therapy both systemically and locally administered, some nanomedicines have already been approved for clinical trials in a variety of CNS tumor conditions to serve as the first steps in the translation of nanotherapy to clinic. Their outcome will steer research directions for further improvements.

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“…Delivery of chemotherapeutics to cancer cells with the goal of reducing toxic effects on healthy tissues is of critical importance. Although, development and optimization of various strategies for improvement of this new delivery approach is a major challenge for future cancer targeted imaging and therapy [1,4,[6][7][8][9]. Various targeting ligands have been conjugated to HA nanoparticles, which have shown proper tumor cell targeting and enhanced therapeutic efficacy in vitro.…”

Section: Introductionmentioning

confidence: 99%