Nanoparticles of nucleotide-free analogue of vitamin B12 formed in protein nanocarriers and their neuroprotective activity in vivo

Maiorova, Larissa A.; Gromova, Olga A.; Torshin, Ivan Yu.; Bukreeva, Tatiana V.; Pallaeva, Tatiana N.; Nabatov, Boris V.; Dereven’kov, Ilia A.; Bobrov, Yurii A.; Bykov, Andrei A.; Demidov, Vadim I.; Kalacheva, Alla G.; Bogacheva, Tatiana E.; Grishina, Tatiana R.; Nikolskaya, Elena D.; Yabbarov, Nikita G.

doi:10.1016/j.colsurfb.2024.114165

Colloids and Surfaces B: Biointerfaces

2024

DOI: 10.1016/j.colsurfb.2024.114165

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Nanoparticles of nucleotide-free analogue of vitamin B12 formed in protein nanocarriers and their neuroprotective activity in vivo

Larissa A. Maiorova,

Olga A. Gromova,

Ivan Yu. Torshin

et al.

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2024

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Cited by 2 publications

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Vitamins and other nutrients that support nitric oxide homeostasis and counteract the development of endotheliopathy

Torshin,

Gromova,

Chuchalin

et al. 2024

RJTAO

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Regulation of blood nitric oxide (NO) levels is an essential component of maintaining cerebrovascular and cardiovascular blood flow. The production of NO in the vascular endothelium is influenced by numerous factors, including the supply of macro- and micronutrients. This article presents the results of systematization of data on the relationship between NO metabolism and nutrient factors. Particular attention is paid to the effect of group B vitamins (folates, vitamins B1, B2, B7 and B12) and the microbiome on vascular endothelial function, NO synthase activity and the prevention of oxidative-nitrosative stress. The correction of deficiencies in these vitamins (group B, A, C, E, D3), magnesium and calcium is an important part of the prevention of stress and a variety of diseases of the nervous system associated with endothelial dysfunction.

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Vitamins and other nutrients that support nitric oxide homeostasis and counteract the development of endotheliopathy

Torshin,

Gromova,

Chuchalin

et al. 2024

RJTAO

View full text Add to dashboard Cite

show abstract

Biosensors for measuring nitric oxide NO levels in biosubstrates: a systematic analysis

Torshin,

Gromova,

Mayorova

et al. 2024

Farmakoèkonomika

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Nitric oxide NO is a signaling molecule involved in numerous physical and pathological processes in biological systems. Highly sensitive sensor materials for measuring NO amounts in vivo in exhaled air and in body fluids (saliva, blood, urine) can be a useful tool in diagnostics and management of patients with bronchopulmonary, cardiovascular, neurological and tumor diseases. Several approaches to measuring NO in biosubstrates (including exhaled air) have been developed: fluorescence/chemiluminescence, electron spin resonance, electrochemical/amperometric (organic and inorganic) and enzymatic/protein sensors. Semiconductors, transition metal nitrides, phthalocyanine complexes, porphyrin and cobalamin derivatives with metals can serve as materials for NO sensors. Creating sensor materials based on vitamin B12 derivatives is an urgent research task in biomedicine. The article systematizes information on using various compounds as materials for NO-sensitive and selective sensors to measure/evaluate NO levels in various biosubstrates.

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Nanoparticles of nucleotide-free analogue of vitamin B12 formed in protein nanocarriers and their neuroprotective activity in vivo

Cited by 2 publications

References 62 publications

Vitamins and other nutrients that support nitric oxide homeostasis and counteract the development of endotheliopathy

Vitamins and other nutrients that support nitric oxide homeostasis and counteract the development of endotheliopathy

Biosensors for measuring nitric oxide NO levels in biosubstrates: a systematic analysis

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