Nanoparticles Self-Assembly within Lipid Bilayers

Chan, Henry

doi:10.1021/acsomega.8b01445

Cited by 26 publications

(27 citation statements)

References 73 publications

(102 reference statements)

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“…Here, the NCL (National Characterization Laboratory) has screened over 100 various nanoparticles and concluded that size, surface charge and hydrophobicity are the most relevant parameters with regard to biocompatibility (Mcneil, 2009). Functionalization of lipid membranes by nanoparticles provides a number of functionalities and remains of continuous interest (Chan and Král, 2018). Both the hydrophilic adsorption of nanoparticles on the other part of the membrane (Volodkin et al, 2009c) or the incorporation of nanoparticles into the hydrophobic core of lipid bilayers (Rasch et al, 2010) is possible.…”

Section: Hybrid and Composite Materialsmentioning

confidence: 99%

Hierarchy of Hybrid Materials—The Place of Inorganics-in-Organics in it, Their Composition and Applications

et al. 2019

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Hybrid materials, or hybrids incorporating both organic and inorganic constituents, are emerging as a very potent and promising class of materials due to the diverse, but complementary nature of the properties inherent of these different classes of materials. The complementarity leads to a perfect synergy of properties of desired material and eventually an end-product. The diversity of resultant properties and materials used in the construction of hybrids, leads to a very broad range of application areas generated by engaging very different research communities. We provide here a general classification of hybrid materials, wherein organics– in -inorganics (inorganic materials modified by organic moieties) are distinguished from inorganics– in –organics (organic materials or matrices modified by inorganic constituents). In the former area, the surface functionalization of colloids is distinguished as a stand-alone sub-area. The latter area—functionalization of organic materials by inorganic additives—is the focus of the current review. Inorganic constituents, often in the form of small particles or structures, are made of minerals, clays, semiconductors, metals, carbons, and ceramics. They are shown to be incorporated into organic matrices, which can be distinguished as two classes: chemical and biological. Chemical organic matrices include coatings, vehicles and capsules assembled into: hydrogels, layer-by-layer assembly, polymer brushes, block co-polymers and other assemblies. Biological organic matrices encompass bio-molecules (lipids, polysaccharides, proteins and enzymes, and nucleic acids) as well as higher level organisms: cells, bacteria, and microorganisms. In addition to providing details of the above classification and analysis of the composition of hybrids, we also highlight some antagonistic yin-&-yang properties of organic and inorganic materials, review applications and provide an outlook to emerging trends.

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Section: Hybrid and Composite Materialsmentioning

confidence: 99%

Hierarchy of Hybrid Materials—The Place of Inorganics-in-Organics in it, Their Composition and Applications

et al. 2019

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“…30 For example, recent simulations and experiments have shown that amphiphilic NPs can insert into the bilayer core, 23,[31][32][33] charged NPs can adsorb to the bilayer surface, 34,35 NP adsorption can drive cooperative bilayer shape changes, 36,37 and hydrophobic NPs can cluster within the bilayer core. 38,39 These studies demonstrate the capability for simulation predictions and experimental evidence to further advance our understanding of NPmembrane interactions.…”

mentioning

confidence: 80%

“…Numerous experimental and computational studies have thus studied interactions between small NPs with varying surface properties and single‐component lipid bilayers as model cell membranes, 13,22 typically utilizing zwitterionic lipids to mimic the dominant lipid component of the plasma membrane 30 . For example, recent simulations and experiments have shown that amphiphilic NPs can insert into the bilayer core, 23,31‐33 charged NPs can adsorb to the bilayer surface, 34,35 NP adsorption can drive cooperative bilayer shape changes, 36,37 and hydrophobic NPs can cluster within the bilayer core 38,39 . These studies demonstrate the capability for simulation predictions and experimental evidence to further advance our understanding of NP–membrane interactions.…”

Section: Introductionmentioning

confidence: 91%

Bilayer‐mediated assembly of cationic nanoparticles adsorbed to lipid bilayers: Insights from molecular simulations

Sheavly

Lehn

2020

AIChE Journal

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Understanding interactions between functionalized gold nanoparticles (NPs) and lipid bilayers is essential for biomedical applications. Experiments have shown that NPs that are stable in solution can assemble into clusters when adsorbed to a lipid bilayer, suggesting that bilayer-mediated interactions facilitate assembly. In this work, we use coarse-grained molecular dynamics simulations to study bilayer-mediated interactions between NPs adsorbed to single-and multicomponent lipid bilayers. We perform unbiased simulations and umbrella sampling calculations using an implicit solvent force field to determine the thermodynamic contributions to assembly. We show that bilayer-mediated interactions drive the assembly of NPs into linear aggregates on liquid-disordered bilayers, which we attribute to a reduction in bilayer curvature. Similar bilayer-mediated interactions induce the alignment of NP clusters with phase boundaries in phase-separated bilayers. Together, these simulation results provide new physical insight into the balance of forces that dictate the assembly of charged NPs at multicomponent lipid bilayer interfaces.

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“…Nanoliposomes represent nanosized self-assembled vesicles which consist of phospholipid bilayers entrapping one or more aquatic compartments (Chan and Král, 2018). There are fine oil-in-water (o/w) dispersions with droplet sizes ranging between 50 and 450 nm (Bozzuto and Molinari, 2015).…”

Section: Nanoliposomesmentioning

confidence: 99%

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

Vaiserman

Koliada

Zayachkivska

et al. 2020

Front. Bioeng. Biotechnol.

149

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The aging process is known to be associated with heightened oxidative stress and related systemic inflammation. Therefore, antioxidant supplementation is regarded as a promising strategy to combat aging and associated pathological conditions. Food-grade antioxidants from plant-derived extracts are the most common ingredients of these supplements. Phyto-bioactive compounds such as curcumin, resveratrol, catechins, quercetin are among the most commonly applied natural compounds used as potential modulators of the free radical-induced cellular damages. The therapeutic potential of these compounds is, however, restricted by their low bioavailability related to poor solubility, stability, and absorbance in gastrointestinal tract. Recently, novel nanotechnology-based systems were developed for therapeutic delivery of natural antioxidants with improved bioavailability and, consequently, efficacy in clinical practice. Such systems have provided many benefits in preclinical research over the conventional preparations, including superior solubility and stability, extended half-life, improved epithelium permeability and bioavailability, enhanced tissue targeting, and minimized side effects. The present review summarizes recent developments in nanodelivery of natural antioxidants and its application to combat pathological conditions associated with oxidative stress.

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Nanoparticles Self-Assembly within Lipid Bilayers

Cited by 26 publications

References 73 publications

Hierarchy of Hybrid Materials—The Place of Inorganics-in-Organics in it, Their Composition and Applications

Hierarchy of Hybrid Materials—The Place of Inorganics-in-Organics in it, Their Composition and Applications

Bilayer‐mediated assembly of cationic nanoparticles adsorbed to lipid bilayers: Insights from molecular simulations

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

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