Nanoparticles targeting at methylases with high correlation to N6-methyladenosine-related lncRNA signatures as potential therapy of kidney clear cell carcinoma

Chen, Ruixuan; Ouyang, Ping; Ling, Su; Xu, Xi; Lian, Peiwen; Li, Yanqin; Gao, Qi; Zhang, Yifan; Nie, Sheng; Luo, Fan; Xu, Ruqi; Zhang, Xiaodong; Li, Xiaoxi; Cao, Yue; Gao, Peiyan; Kang, Juanjuan; Wu, Jun; Lu, Li

doi:10.1016/j.cclet.2022.03.074

Cited by 16 publications

(7 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4 In addition, the creation of novel antitumor drugs and various drug-delivery systems have been required to enhance the site specicity and bio-availability of medications, hence, increasing the therapeutic efficacy and reducing systemic toxicity. 5 With the aim of improving the effectiveness of chemotherapy and decreasing its side effects, the electrospinning technique has been employed for the fabrication of polymer bers of diameters ranging from a few nanometers to several micrometers with a broad range of applications. [6][7][8] This includes nano-drug delivery systems for the treatment of cancer.…”

Section: Introductionmentioning

confidence: 99%

Novel electrospun fibers as carriers for delivering a biocompatible Sm(iii) nanodrug for cancer therapy: fabrication, characterization, cytotoxicity and toxicity

Fouad

Ali

2023

RSC Adv.

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Novel electrospun fibers as carriers for delivering a biocompatible Sm(iii) nanodrug for cancer therapy: fabrication, characterization, cytotoxicity and toxicity

Fouad

Ali

2023

RSC Adv.

View full text Add to dashboard Cite

show abstract

“…They easily entered ccRCC cells. This work shows that m6ArlncRNA levels may describe the tumor microenvironment, predict prognosis, and recommend ccRCC treatments [161] …”

Section: Nanoparticle‐mediated Lncrnas‐targeting Strategies Against C...mentioning

confidence: 83%

“…This work shows that m6ArlncRNA levels may describe the tumor microenvironment, predict prognosis, and recommend ccRCC treatments. [161] Nasopharyngeal carcinoma (NPC) also uses nanoparticles to target lncRNAs. Many lncRNAs are abnormally expressed in NPC, possibly contributing to its development.…”

Section: Other Malignanciesmentioning

confidence: 99%

Nanomaterials‐Based Targeting of Long Non‐Coding RNAs in Cancer: A Cutting‐Edge Review of Current Trends

Davodabadi,

Farasati Far,

Sargazi

et al. 2024

ChemMedChem

View full text Add to dashboard Cite

This review article spotlights the burgeoning potential of using nanotherapeutic strategies to target long non‐coding RNAs (lncRNAs) in cancer cells. This updated discourse underlines the prominent role of lncRNAs in instigating cancer, facilitating its progression, and metastasis, validating lncRNAs' potential for being effective diagnostic biomarkers and therapeutic targets. The manuscript offers an in‐depth examination of different strategies presently employed to modulate lncRNA expression and function for therapeutic purposes. Among these strategies, Antisense Oligonucleotides (ASOs), RNA interference (RNAi) technologies, and the innovative CRISPR‐based gene editing tools garner noteworthy mention. A significant section of the review is dedicated to nanocarriers and their crucial role in drug delivery. These nanocarriers' efficiency in targeting lncRNAs in varied types of cancers is elaborated upon, validating the importance of targeted therapy. The manuscript culminates by reaffirming the promising prospects of targeting lncRNAs to enhance the accuracy of cancer diagnosis and improve treatment efficacy. Consequently, new paths are opened to more research and innovation in employing nanotherapeutic approaches against lncRNAs in cancer cells. Thus, this comprehensive manuscript serves as a valuable resource that underscores the vital role of lncRNAs and the various nano‐strategies for targeting them in cancer treatment.

show abstract

“…The following principles were considered when developing this system: (I) adopting biocompatible and biodegradable polymers approved for official clinical application; (II) using a mature system with good sustained-release ability; and (III) being suitable for intra-articular injection to further reduce the side effects of systemic administration of RAPA. PCL and PEG polymers have been widely applied in nanoparticles for their many beneficial properties, including the tendency to prolong the drug circulation time and maintain the physical and chemical stability of drugs, [25][26][27][28][29][30] which was approved in various biomedical applications by the Food and Drug Administration (FDA) in America. [31] Additionally, PCL-PEG NPs have already been employed to deliver a variety of anticancer drugs.…”

Section: Preparation and Characterization Of Rapa/pcl-peg Npsmentioning

confidence: 99%

Local Injection of Rapamycin‐Loaded Pcl‐Peg Nanoparticles for Enhanced Tendon Healing in Rotator Cuff Tears via Simultaneously Reducing Fatty Infiltration and Drug Toxicity

Ye,

Wang,

Zeng

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

As a common cause of shoulder pain, rotator cuff tears (RCTs) are difficult to treat clinically because of their unsatisfactory prognosis due to the fatty infiltration caused by muscle‐derived stem cells (MDSCs). Previous studies have found that rapamycin (RAPA) can inhibit fatty infiltration. However, systemic administration of RAPA may cause complications such as infection and nausea, while local administration of RAPA may lead to the cytotoxicity of tendon cells, affecting the healing of rotator cuffs. In this study, biocompatible and clinically approved polycaprolactone‐polyethylene glycol (PCL‐PEG) is formulated into an injectable nanoparticle for the sustained release of RAPA. The results indicate that the RAPA/PCL‐PEG nanoparticles (NPs) can efficiently prolong the release of RAPA and significantly reduce the cytotoxicity of tendon cells caused by RAPA. The study of the fatty infiltration model in rats with delayed rotator cuff repair shows that weekly intraarticular injection of RAPA/PCL‐PEG NPs can more effectively reduce the fatty infiltration and muscle atrophy of rat rotator cuffs and leads to better mechanical properties and gait improvements than a daily intraarticular injection of RAPA. These findings imply that local injection of RAPA/PCL‐PEG NPs in the shoulder joints can be a potential clinical option for RCTs patients with fatty infiltration.

show abstract

Nanoparticles targeting at methylases with high correlation to N6-methyladenosine-related lncRNA signatures as potential therapy of kidney clear cell carcinoma

Cited by 16 publications

References 37 publications

Novel electrospun fibers as carriers for delivering a biocompatible Sm(iii) nanodrug for cancer therapy: fabrication, characterization, cytotoxicity and toxicity

Novel electrospun fibers as carriers for delivering a biocompatible Sm(iii) nanodrug for cancer therapy: fabrication, characterization, cytotoxicity and toxicity

Nanomaterials‐Based Targeting of Long Non‐Coding RNAs in Cancer: A Cutting‐Edge Review of Current Trends

Local Injection of Rapamycin‐Loaded Pcl‐Peg Nanoparticles for Enhanced Tendon Healing in Rotator Cuff Tears via Simultaneously Reducing Fatty Infiltration and Drug Toxicity

Contact Info

Product

Resources

About