Nanoparticulate delivery systems for alkyl gallates: Influence of the elaboration process on particle characteristics, drug encapsulation and in-vitro release

Chebil, Asma; Léonard, Michèle; Six, Jean‐Luc; Nouvel, Cécile; Durand, Alain

doi:10.1016/j.colsurfb.2017.11.050

Cited by 11 publications

(16 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…32 In both cases, prevention of macroscopic particle formation is critical to maintain the formation of nanoparticles and polymers such as polysaccharides have been reported to deliver effective steric stabilisation. [33][34][35] It is interesting to note that the observed Dz values increased with decreasing HPMC concentration as would be expected from a steric stabilisation mechanism. Our current understanding is that sucrose, as a water soluble hydrophilic and uncharged small molecule, is not specifically contributing to the stabilisation of the nanoprecipitation process but does act to separate the NCL nanoparticles in the final powder and allow redispersion.…”

Section: Resultsmentioning

confidence: 68%

Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection

Hobson¹,

Savage²,

Dwyer³

et al. 2021

Preprint

View full text Add to dashboard Cite

The spread of SARS-CoV-2 across the world requires the formation of a range of interventions that include immunomodulatory or antiviral therapeutics and repurposing of existing drug compounds is an important strategy to rapidly identify possible options. Niclosamide is a cheap and generic drug compound with a proven in vitro ability to inhibit viral replication of SARS-CoV-2; this drug also has known poor oral bioavailability due to very low water solubility. Here, we demonstrate the nanoparticle formulation of niclosamide using a new, cheap and scalable process to enable long-acting injectable administration and show extended circulating drug exposure in vivo over 28 days using a rodent model after depot injection.

show abstract

Section: Resultsmentioning

confidence: 68%

Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection

Hobson¹,

Savage²,

Dwyer³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…AGs have potent therapeutic properties, including antitumoral, antimicrobial, and antiviral properties, and are also potent antioxidants, acting as scavengers of reactive oxygen species (Fuentes et al, 2016;Lacatelly, Filippin-Monteiro, & Creczynski-Pasa, 2013;Maldonado et al, 2011;Rosso et al, 2006;Sergediene et al, 1999;Velasco, Holgado, Dobarganes, & Marquez-Ruiz, 2009). However, to the best of our knowledge, there have been no reports of the encapsulation and release of AGs in nano-and microparticles, with the exception of our previous work on nanoparticles (Chebil et al, 2018b).…”

Section: Introductionmentioning

confidence: 87%

“…10). In previous work, we showed that the kinetics of release from nanoparticles could be satisfactorily fitted assuming that the limiting step was the diffusion of AGs within the solid PLA core, in perfect sink conditions, and with no swelling of the PLA core (Chebil et al, 2018b). We showed that the diffusion coefficients estimated with the previous model were in agreement with literature data and exhibited a limited dependence on drug loading, which was consistent with the idea of a perfect molecular dissolution of AGs in a PLA matrix.…”

Section: In Vitro Release Kineticsmentioning

confidence: 96%

“…In addition, dextran-based stabilizers were efficient for ensuring re-dispersion of the particles after the lyophilization of the suspensions (Rotureau et al, 2006). More recently, we reported a systematic comparison of two elaboration processes for the preparation of dextran-covered PLA nanoparticles: nanoprecipitation (physico-chemical low energy process) and emulsion/solvent evaporation (high energy process) (Chebil, Léonard, Six, Nouvel, & Durand, 2018b). In addition to characterizing the particle size distributions and surface coverage of both processes, their performances for the encapsulation and release of alkyl gallates (AGs) were evaluated and compared.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Process conditions for preparing well-defined nano- and microparticles as delivery systems of alkyl gallates

et al. 2019

Self Cite

View full text Add to dashboard Cite

Suspensions of dextran-covered poly(D,L-lactide) particles were prepared.  Emulsion/solvent evaporation (diffusion) process was used with dextran derivatives.  Varying emulsification conditions led to a wide range of particle diameters.  Encapsulation of alkyl gallates in each particle type was performed and evaluated.  Release kinetics were monitored and compared according to the class of particles. partic-d-18-00083-durand-highlights.docx

show abstract

“…A simple empirical equation known as a power law, expressed as follows, can extensively and successfully describe the first 60% of the release curves [16][17][18]:…”

Section: Kinetic Modelmentioning

confidence: 99%

Towards Boosting Power by Encapsulating Tranexamic Acid into Emulsified Particles

Huang

Lin

2018

Journal of Chemistry

View full text Add to dashboard Cite

In aesthetic medicine, during a course of skin whitening treatment, injections must be frequently administered to achieve a strong curative effect. To develop a method to prevent long-term harm due to injections, this study applied a novel technology for the delivery of whitening agents that achieved long-term slow release of agents, thereby reducing the danger of frequent injections. We utilized biodegradable poly(ethylene glycol)-poly(lactide-co-ε-caprolactone) and Span 85 as surfactants and squalene as the core oil to encapsulate and adsorb tranexamic acid in emulsified particles, respectively. The conductivity test determined that the continuous phase of the obtained emulsified particles was aqueous; tranexamic acid did not play a critical role because of its low content. The controlled release experiment demonstrated that the release rate of tranexamic acid from the emulsified matrix was in the sequence of (1) adsorption, (2) encapsulation plus adsorption, and (3) encapsulation. Encapsulating tranexamic acid can efficiently halt the behavior of sudden release and potentially boost the efficacy of whitening.

show abstract

Nanoparticulate delivery systems for alkyl gallates: Influence of the elaboration process on particle characteristics, drug encapsulation and in-vitro release

Cited by 11 publications

References 62 publications

Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection

Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection

Process conditions for preparing well-defined nano- and microparticles as delivery systems of alkyl gallates

Towards Boosting Power by Encapsulating Tranexamic Acid into Emulsified Particles

Contact Info

Product

Resources

About