Nanopathology - The Health Impact of Nanoparticles

Montanari, Stefano

doi:10.1142/9789814241144

Cited by 36 publications

(50 citation statements)

References 1 publication

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“…Several particles containing Si together with Al were found, which may signalize the presence of aluminosilicates from soil. Elements such as Cu and Al are known to be emitted with cigarette smoke 1 . These elements were found in the tonsils of children whose parents smoke or actively smoking adolescents and adults.…”

Section: Discussionmentioning

confidence: 99%

“…An Italian research team has discussed the potential association between some oncological changes, inflammatory responses, cardiovascular and other cryptogenic diseases and the presence of nano-sized particles deposited in various tissues within the human body 1 . Nano-sized particles have been described in many studies to be significantly different in terms of their reactivity and behavior in various environmental media (air, water, and soil).…”

Section: Introductionmentioning

confidence: 99%

“…wear of automotive brake pad releases Fe, Cu, Ba, and Sb into the environment 7 . Various anthropogenic processes, such as cigarette smoking, may produce these metal-containing particles where the smoke may contain metals such as Al, Cd, Ni, Pb, and Cu in the form of very fine particles 1 . Metals, such as Fe, Cu, Zn, Sn, Ba, Sb and Ti are being emitted as nano-sized particles by the combustion of fossil fuels.…”

Section: Introductionmentioning

confidence: 99%

“…The first references to these nanopathologies were associated mainly with military patients who developed illness in connection with war conflicts like the "Gulf War Syndrome" and "Balkan Syndrome", etc. Medical examination data of firefighters and rescuers exposed to fine and ultrafine dust emitted after the World Trade Center collapse in New York have also contributed to knowledge on the health impact of fine metallic particle inhalation 1 . Metals are known for their carcinogenic potential due to inhibition of the DNA repair mechanisms 8 .…”

Section: Introductionmentioning

confidence: 99%

“…Nano-sized particles may enter the body via inhalation, digestion and skin penetration. In the body, they can be translocated via the blood and lymphatic system to sensitive target tissues/organs 1,2,10 . Transport of nano-sized particles across the blood-brain barrier and/or olfactory pathway has been found in some animal studies 11,12 .…”

Section: Introductionmentioning

confidence: 99%

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Detection of nano- and micro-sized particles in routine biopsy material - pilot study

Jana¹,

Bielniková²,

Kukutschová³

et al. 2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background. Nanotechnology is receiving enormous funding. Very little however is known about the health dangers of this technology so far. Chronic tonsillitis is one of a number of diseases called idiopathic. Among other factors, the tonsils are exposed to suspended particles in inhaled air including nano particles. The objective of this study was to detect and evaluate metallic particles in human tonsil tissue diagnosed with chronic tonsillitis and in amniotic fluid as a comparison. Methods. Scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX) was used for identification of solid particles in a total of 64 samples of routinely analyzed biopsy and cytologic material. Results. Almost all samples were found to contain solid particles of various metals. The most frequent, regardless of diagnosis, were iron, chromium, nickel and aluminium. The size, determined using SEM, varied from around 500 nm to 25 μm. The majority formed aggregates of several micrometers in size but there were a significant number of smaller (sub-micrometer or nano-sized) particles present. The incidence of metallic particles was similar in child and adult tissues. The difference was in composition: the presence of several metals in adults was due to occupational exposure. Conclusions. The presence of metallic particles in pathologically altered tissues may signal an alternative causation of some diseases. The ethiopathogenic explanation of these diseases associated with the presence of nano-sized particles in the organism has emerged into a new field of pathology, nanopathology.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Detection of nano- and micro-sized particles in routine biopsy material - pilot study

Jana¹,

Bielniková²,

Kukutschová³

et al. 2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Analysis of particulate pollution on foodstuff and other items by environmental scanning electron microscopy

Giordano¹,

Bardi

Garbini

et al. 2011

Microscopy Res & Technique

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Combustion processes commonly create fine and ultrafine particles whose effects are often harmful to human health. The present study is aimed at providing more data in this field by testing the capability of environmental electron scanning microscopy of detecting and analyzing such particles. For this purpose, we examined a range of samples taken from everyday food items collected in Tuscany. The results showed that, within the examined samples, inorganic particles can be observed in the nano-and micrometer range. These particles are attributable mostly to natural processes and, in part, to food processing. Little evidence is found for particles whose origin could be attributed to industrial combustion processes, such as waste incineration. Microsc. Res. Tech. 74:931-935, 2011. V

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Raman microspectroscopy as a useful tool for nanopathology

Čabanová

Peikertová

Bielniková

et al. 2016

J Raman Spectroscopy

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Interactions between organisms and micro‐ and nano‐sized particles are studied in a relatively new research field—nanopathology. Some diseases (oncological and/or inflammatory) may be connected with accumulation of the particles in the tissues. In general, precise and accurate qualitative evaluation of chemical composition of particles is very important. In such analyses, scanning electron microscopy with energy dispersive X‐ray spectroscopy is used most often. Nevertheless, it reveals merely the elemental composition of particles/clusters. On the other hand, because Raman microspectroscopy is non‐destructive and it is coupled with an optical microscope, it has potential for detection of particles of unknown nature; in addition, it allows determination of the chemical composition of these particles/clusters. Therefore, this technique could be a very useful supporting tool for nanopathology. The aim of the presented study is to survey the possibilities and advantages of Raman microspectroscopy for the detection and characterization of particles of an unknown nature in the samples of human nasal mucosa and amniotic fluids. Three different approaches of analysis are hereby discussed: (1) analysis of the entire area of the sample, (2) division of the sample in sections, and subsequent analysis of a defined number of points in selected parts, and (3) Raman spectral imaging of the selected parts. Results clearly prove high efficiency of Raman microspectroscopy as a tool for characterization of the particles/clusters in human tissues and body fluids, and thus it may allow a better understanding of the potential impact to human health in relation to specific diagnoses. Copyright © 2016 John Wiley & Sons, Ltd.

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Nanopathology - The Health Impact of Nanoparticles

Cited by 36 publications

References 1 publication

Detection of nano- and micro-sized particles in routine biopsy material - pilot study

Detection of nano- and micro-sized particles in routine biopsy material - pilot study

Analysis of particulate pollution on foodstuff and other items by environmental scanning electron microscopy

Raman microspectroscopy as a useful tool for nanopathology

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