Nanopharmaceuticals for wound healing – Lost in translation?

Ashtikar, Mukul; Wacker, Matthias G.

doi:10.1016/j.addr.2018.03.005

Cited by 71 publications

(47 citation statements)

References 257 publications

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“…One of the leading polymers in the biomedical area is poly(lactic acid) (PLA), a green, bioabsorbable, and biodegradable polymer with excellent biocompatibility and ability to incorporate a great variety of active substances . The degradation of PLA results in the formation of lactic acid, which is easily metabolized by the human body, being innocuous to the wound healing process .…”

Section: Introductionmentioning

confidence: 99%

Electrospun poly(lactic acid) nanofibers loaded with silver sulfadiazine/[Mg–Al]‐layered double hydroxide as an antimicrobial wound dressing

Malafatti

Bernardo

Moreira

et al. 2020

Polymers for Advanced Techs

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Poly(lactic acid) (PLA) is a versatile, bioabsorbable, and biodegradable polymer with excellent biocompatibility and ability to incorporate a great variety of active agents. Silver sulfadiazine (SDZ) is an antibiotic used to control bacterial infection in external wounds. Aiming to combine the properties of PLA and SDZ, hydrotalcite ([Mg-Al]-LDH) was used as a host matrix to obtain an antimicrobial system efficient in delivering SDZ from electrospun PLA scaffolds intended for wound skin healing. The structural reconstruction method was successfully applied to intercalate silver sulfadiazine in the [Mg-Al]-LDH, as evidenced by X-ray diffraction and thermogravimetric analyses. Observations by scanning electron microscopy revealed a good distribution of SDZ-[Mg-Al]-LDH within the PLA scaffold. Kinetics studies revealed a slow release of SDZ from the PLA scaffold due to the intercalation in the [Mg-Al]-LDH. In vitro antimicrobial tests indicated a significant inhibitory effect of SDZ-[Mg-Al]-LDH against Escherichia coli and Staphylococcus aureus. This antibacterial activity was sustained in the 2.5-wt% SDZ-[Mg-Al]-LDH-loaded PLA nanofibers, which also displayed excellent biocompatibility towards human cells. The multifunctionality of the PLA/SDZ-[Mg-Al]-LDH scaffold reported here is of great significance for various transdermal applications. K E Y W O R D S drug release, electrospinning, hydrotalcite, sulfadiazine silver, wound healing

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Section: Introductionmentioning

confidence: 99%

Electrospun poly(lactic acid) nanofibers loaded with silver sulfadiazine/[Mg–Al]‐layered double hydroxide as an antimicrobial wound dressing

Malafatti

Bernardo

Moreira

et al. 2020

Polymers for Advanced Techs

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“…For a wound to heal successfully, several cellular and molecular mechanisms have to act in a proper temporal sequence . Improper healing causes the wound to enter an intransigent phase of chronicity, due to a high severity score of the injury itself or to a low health state of the patient.…”

Section: Introductionmentioning

confidence: 99%

“…For instance, the fast growing incidence of diabetes mellitus exposes many patients to the risk of developing such a chronic non‐healing complication as foot ulcer . In these conditions, high concentrations of proteases, reactive oxygen species, senescent cells, and impaired stem cells are all hallmarks of chronic wounds …”

Section: Introductionmentioning

confidence: 99%

“…In recent years, artificial scaffoldings acting as skin substitutes have been developed to improve wound healing . Because of its relative abundance in bodily proteins, its structural role as a main component of the extracellular matrix, and its low immunogenicity and high stability, collagen is par excellence the best biomaterial to be employed as a prosthetic medical device for wound healing, except for patients prone to keloid scaring, for whom collagen deposition in the wound bed is excessive .…”

Section: Introductionmentioning

confidence: 99%

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Characterization of Collagen/Lipid Nanoparticle–Curcumin Cryostructurates for Wound Healing Applications

Masci

Taddei

Courant

et al. 2019

Macromolecular Bioscience

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NanoparticlesCurcumin-loaded collagen cryostructurates have been devised for wound healing applications. Curcumin displays strong antioxidant, antiseptic, and anti-inflammatory properties, while collagen is acknowledged for promoting cell adhesion, migration and differentiation. However, when curcumin is loaded directly into collagen hydrogels, it forms large molecular aggregates and clogs the matrix pores. A double-encapsulation strategy is therefore developed by loading curcumin into lipid nanoparticles (LNP), and embedding these particles inside collagen scaffolds. The resulting collagen/LNP cryostructurates have an optimal fibrous structure with ≈100 µm average pore size for sustaining cell migration. Results show that collagen is structurally unaltered and that nanoparticles are homogeneously distributed amidst collagen fibers. Hydrogels soaked in saline buffer release about 20 to 30% of their nanoparticles content within 24 h, while achieved 100% release after 25 days. When exposed to NIH 3T3 fibroblasts, these hydrogels provide a satisfactory scaffold for cell interaction as early as 4 h after seeding, with no cytotoxic counter effect. These positive features make the collagen/lipid cryostructurates a promising material for further use in wound healing.

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“…This special issue provides insights into some of the molecular mechanisms inherent to wound healing and fibrosis [13][14][15][16] and highlighting the use of cell-and tissue-models for basic research and drug discovery [17,18]. The use of several approaches for treating or preventing such pathologies is also discussed, including bioactive [19][20][21], electroactive [22] and stimuli-responsive [23] biomaterialbased approaches; gene, drug, proteoglycan and growth factor based approaches [24][25][26][27][28][29][30][31][32][33][34]; cellular and cellular-derived based therapies [35][36][37]; and matrix modulation strategies [38]. Considering the significant strides made in understanding the molecular mechanisms operating in normal and pathological wound healing and the promising therapeutic approaches described herein, it is expected that in the near future, some of these technologies will satisfy clinical needs and enter commercialisation.…”

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confidence: 99%