Nanophthalmos With Uveal Effusion

Brockhurst, Robert J.

doi:10.1001/archopht.1975.01010020923001

Cited by 153 publications

(67 citation statements)

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“…The association of nanophthalmos with uveal effusion was first reported by Brockhurst. 10 The uveal effusion may develop either from the thickening of sclera and the reduced scleral permeability to proteins, or from the dense collagen around the vortex veins and the resulting compression of venous drainage channels. Thickening of the sclera has been implicated in the pathogenesis of uveal effusion and serous retinal detachment in patients with nanophthalmos.…”

Section: Discussionmentioning

confidence: 99%

Management of glaucoma in patients with nanophthalmos

Yalvaç

Şatana

Özkan

et al. 2007

Eye

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Aims In this retrospective study, we aimed to evaluate the results of glaucoma surgery in patients with nanophthalmos. Methods Twenty-eight bilateral nanophthalmic patients, of whom 20 patients underwent trabeculectomy þ Mitomycin-C (MMC) þ inferior sclerotomy between 1996 and 2004, were included in this study. Records of patients with nanophthalmos were reviewed. Intraocular pressure (IOP), glaucoma medications, surgical success, visual acuity and complications were analyzed. Results The mean IOP was 34.675.3 mm Hg preoperatively. At the final follow-up visit, the mean IOP dropped to 21.4177.34 mm Hg (Po0.05). The cumulative probability of success was 85% at 1 year, 78.5% at 2 years, 76.9% at 3 years, 70.6% at 4 years and 47% at 5 years after surgery. Visual acuity decreased in 13 (65%) patients but no eye lost vision. Sequels of choroidal detachment (five patients 25%) and retinal folds (four patients 20%) were the most frequent reason for visual decrease. Uveal effusion (10 patients 50%) and cataract formation (seven patients 35%) were major late postoperative complications. Conclusions Results indicate that trabeculectomy þ MMC þ inferior sclerotomy procedure was effective and safe for glaucoma control in patients with nanophthalmos, but uveal effusion is a major problem and cataract surgery is expected in the long run.

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Section: Discussionmentioning

confidence: 99%

Management of glaucoma in patients with nanophthalmos

Yalvaç

Şatana

Özkan

et al. 2007

Eye

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“…The recognition of nanophthalmos is particularly important when it comes to the treatment of angel-closure glaucoma. Several authors have reported a high incidence of postoperative complications in nanophthalmic eyes, with severe uveal effusion and total retinal detachment a few days after surgery (Brockhurst 1975;Singh et al 1982;Jin & Anderson 1990). The sudden drop in IOP to zero, that occurs during a peripheral iridectomy, results in a relative increase in the choroidal venous pressure and an aggravation of the uveal effusion (Brockhurst 1980).…”

Section: Discussionmentioning

confidence: 99%

“…The anterior chamber is frequently shallow due to the relatively large volume occupied by the lens. Usually, nanophthalmic patients suffer from hypermetropia between π10 and π20 diopters (D) (Brockhurst 1975).…”

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confidence: 99%

“…Both the anatomical abnormalities of the eye and uveal effusion, which lead to a forward displacement of the iris and ciliary body, may cause the angle closure (Ryan et al 1982). The association of nanophthalmos and uveal effusion was first described by Brockhurst (1975). The underlying cause may be the thickened sclera leading to an obstruction of the vortex veins and a reduced transscleral drainage of proteinrich fluid from the suprachoroidal space (Brockhurst 1980;Gass 1983).…”

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Exudative retinal detachment in nanophthalmos

Krohn

Seland

1998

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To report the treatment of exudative retinal detachment in a patient with nanophthalmos. Methods: A 46-year-old man with bilateral nanophthalmos suffered from acute angle-closure glaucoma in his left eye. The first day after a peripheral iridectomy an exudative retinal detachment was obseved. Two months later a partial thickness sclerectomy with a central sclerostomy, covered by a thin film of absorbable gelatine, was performed in each quadrant of the left eye. Results: The retinal detachment gradually resolved and after eight months the retina was completely reattached. Vision, which had been limited to hand movements, improved to 6/18 with correction. Conclusion: Scleral resections are effective in the treatment of nanophthalmic retinal detachment. The use of absorbable gelatine film to cover the sclerectomized area may prevent regeneration of scleral tissue and recurrence of the exudative retinal detachment.

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“…1 Schepens and Brockhurst first described and divided UES into idiopathic versus one associated with high hypermetropy and nanophthalmus. [2][3][4] The suggested therapy according to Gass 5 and Jackson et al 6 is partial or full-thickness sclerectomy or sclerotomy with mytomycin C. 7 Medical therapy for UES with long-term oral NSAIDs has been described with variable results. 8 Prostaglandin analogues (PAs) have been shown to increase uveoscleral outflow by increasing scleral permeability, 9 and have been used postoperatively to treat UES with equivocal benefit in one patient, 10 but they have not previously been reported as a primary treatment.…”

Section: Introductionmentioning

confidence: 99%

Medical therapy for uveal effusion syndrome

Derk¹,

Benčić²,

Ćorluka

et al. 2014

Eye

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Purpose To report a case series of three patients with bilateral uveal effusion syndrome (UES), treated conservatively with oral carbonic anhydrase inhibitors and topical prostaglandin analogues (PAs). Methods Three patients with bilateral UES were treated with the same initial therapy. Topical PA latanoprost 0.005% and acetazolamide 250 mg were administered in order to reduce intraocular pressure, improve uveoscleral outflow, and facilitate resolution of uveal effusion. Results The chorioretinal detachment resolved within 3 months in two reported patients while the third one underwent surgery on his left eye. After clinical improvement, further oral therapy with acetazolamide was stopped, while topical prostaglandins were continued for at least the next 3 months. All patients were free from recurrence during the follow-up period. Conclusion Although the usually recommended UES therapy is partial or full-thickness sclerectomy, our case series showed apparent resolution of chorioretinal detachment in two patients on medical therapy alone. Conservative therapy may be the first step before the standard recommended surgical approach, but further studies are needed to verify the effectiveness of reported therapy.

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Nanophthalmos With Uveal Effusion

Cited by 153 publications

References 11 publications

Management of glaucoma in patients with nanophthalmos

Management of glaucoma in patients with nanophthalmos

Exudative retinal detachment in nanophthalmos

Medical therapy for uveal effusion syndrome

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