Nanophytopharmaceuticals

Mukne, Alka; Nair, Swapna S.; Momin, Misbah

doi:10.1201/9781351139281-6

Cited by 3 publications

(3 citation statements)

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“…The most toxic oil has given 100 units on the toxicity index scale LC: lethal values; X2: Chi: squared; df: degree of freedom; Sig. significance; R 2 : R-squared is a goodness-of-fit measure in case of linear regression models senkyunolide-J (Momin & Nair, 2001). A. graveolens oil contains major constituents such as lactones, flavonoids, and terpenoids, which could play a role in its toxicity (Kumar et al, 2014).…”

Section: Resultsmentioning

confidence: 99%

The Bioefficacy of Essential Oils against the False Stable Fly, Muscina stabulans (Harris) (Diptera: Muscidae)

Khater

Gad

Mahmoud³

et al. 2023

Benha Journal of Applied Sciences

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Section: Resultsmentioning

confidence: 99%

The Bioefficacy of Essential Oils against the False Stable Fly, Muscina stabulans (Harris) (Diptera: Muscidae)

Khater

Gad

Mahmoud³

et al. 2023

Benha Journal of Applied Sciences

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“…These properties have been observed in other studies as well. [37,38] Several studies have also reported on the antioxidant activity of Pelargonium species, including P. endlicherianum. [14,16] found that the trapping capacity of P. endlicherianum was significant, indicating that it has strong antioxidant activity.…”

Section: Total Phenolic and Flavonoid Contentsmentioning

confidence: 99%

UHPLC‐ESI‐QTOF‐MS metabolite profiles of different extracts from Pelargonium endlicherianum parts and their biological properties based on network pharmacological approaches

Zengin,

Leyva‐Jiménez,

Fernández‐Ochoa

et al. 2024

Archiv der Pharmazie

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In the present study, we aimed to investigate the chemical profiles and biological activities of different extracts (ethyl acetate, dichloromethane, ethanol, and water) of Pelargonium endlicherianum parts (aerial parts and roots). Free radical scavenging, reducing power, phosphomolybdenum, and metal chelating were assayed for antioxidant properties. To detect enzyme inhibitory properties, cholinesterase, amylase, glucosidase, and tyrosinase were chosen as target enzymes. The ethanol extract of the aerial parts contained higher amounts of total bioactive compounds (120.53 mg GAE/g‐24.46 mg RE/g). The ethanol and water extracts of these parts were tentatively characterized by UHPLC‐ESI‐QTOF‐MS and 95 compounds were annotated. In addition, the highest acetylcholiesterase (3.74 mg GALAE/g) and butyrylcholinesterase (3.92 mg GALAE/g) abilities were observed by the ethanol extract of roots. The water extract from aerial parts exhibited the most pronounced inhibitory effects on multiple cancer cell lines, especially A549 (IC50: 23.2 µg/mL) and HT‐29 (IC50: 27.43 µg/mL) cells. Using network pharmacology, P. endlicherianum compounds were studied against cancer, revealing well‐connected targets such as epidermal growth factor receptor (EGFR), phosphoinositide‐3‐kinase (PI3K), AKT, receptor tyrosine‐protein kinase erbB‐2, and growth factor receptor bound protein 2 (GRB2) with significant impact on cancer‐related pathways. The results could open a new path from natural treasure to functional applications with P. endlicherianum and highlight a new study on other uninvestigated Pelargonium species.

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“…To formulate herbal drugs into a potential dosage form is quite tedious and difficult owing to their poor solubility profiles. Novel drug delivery system provides an innovative platform to develop herbal medicines into potent dosage forms [14]. The ideal drug delivery system is capable of drug targeting and also provides control over the release of the drug from the formulation and reaches optimum therapeutic effect while causing minimum side effects.…”

Section: Introductionmentioning

confidence: 99%