Nanoplatform-based strategies for enhancing the lethality of current antitumor PDT

Lu, Xin-Xin; Xue, Chun; Dong, Jian-Hui; Zhang, Yi-Zhou; Gao, Fan

doi:10.1039/d4tb00008k

Cited by 6 publications

(2 citation statements)

References 138 publications

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“…18,19 Both PTT and PDT have unique advantages, such as low side effects, high therapeutic selectivity and negligible drug resistance. 20–24 Besides, SDT utilizes sonosensitizers to generate ROS via the sonodynamic effect under ultrasound (US) irradiation. 25–27 Similar to PDT, SDT has been reported to have slight toxicity to adjacent normal tissues and thus widely used for tumor ablation.…”

Section: Introductionmentioning

confidence: 99%

Radioactive hybrid semiconducting polymer nanoparticles for imaging-guided tri-modal therapy of breast cancer

Gu,

Cheng,

et al. 2024

J. Mater. Chem. B

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Section: Introductionmentioning

confidence: 99%

Radioactive hybrid semiconducting polymer nanoparticles for imaging-guided tri-modal therapy of breast cancer

Gu,

Cheng,

et al. 2024

J. Mater. Chem. B

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“…Fortunately, with the rapid development of nanotechnology, multiple challenges in the biomedical field have been greatly improved and even surmounted due to the remarkable sensitization effects of nanomaterials across various antitumor treatments. − In response to the aforementioned challenge, numerous sophisticated designs, particularly those based on nanoplatforms, have been developed to strengthen the TTS-elicited immune response and enable effective antitumor therapy when combined with immune agents. Here, we outline the recent progress of these advanced strategies in the application of tumor therapy (Figure and Table ).…”

Section: Introductionmentioning

confidence: 99%

Advanced Strategies for Strengthening the Immune Activation Effect of Traditional Antitumor Therapies

Ning,

Lu,

Dong

et al. 2024

ACS Biomater. Sci. Eng.

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The utilization of traditional therapies (TTS), such as chemotherapy, reactive oxygen species-based therapy, and thermotherapy, to induce immunogenic cell death (ICD) in tumor cells has emerged as a promising strategy for the activation of the antitumor immune response. However, the limited effectiveness of most TTS in inducing the ICD effect of tumors hinders their applications in combination with immunotherapy. To address this challenge, various intelligent strategies have been proposed to strengthen the immune activation effect of these TTS, and then achieve synergistic antitumor efficacy with immunotherapy. These strategies primarily focus on augmenting the tumor ICD effect or facilitating the antigen (released by the ICD tumor cells) presentation process during TTS, and they are systematically summarized in this review. Finally, the existing bottlenecks and prospects of TTS in the application of tumor immune regulation are also discussed.

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Metal‐Coordinated Polydopamine Structures for Tumor Imaging and Therapy

Wang,

Song,

Jiang

et al. 2024

Adv Healthcare Materials

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Meticulously engineered nanomaterials achieve significant advances in the diagnosis and therapy of solid tumors by improving tumor delivery efficiency; and thereby, enhancing imaging and therapeutic efficacy. Currently, polydopamine (PDA) attracts widespread attention because of its biocompatibility, simplicity of preparation, abundant surface groups, and high photothermal conversion efficiency, which can be applied in drug delivery, photothermal therapy, theranostics, and other nanomedicine fields. Inspired by PDA structures that are rich in catechol and amino functional groups that can coordinate with various metal ions, which have charming qualities and characteristics, metal‐coordinated PDA structures are exploited for tumor theranostics, but are not thoroughly summarized. Herein, this review summarizes the recent progress in the fabrication of metal‐coordinated PDA structures and their availabilities in tumor imaging and therapy, with further in‐depth discussion of the challenges and future perspectives of metal‐coordinated PDA structures, with the aim that this systematic review can promote interdisciplinary intersections and provide inspiration for the further growth and clinical translation of PDA materials.

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Nanoplatform-based strategies for enhancing the lethality of current antitumor PDT

Abstract: Photodynamic therapy (PDT) exhibits great application prospects in future clinical oncology due to its spatiotemporal controllability and good biosafety. However, the antitumor efficacy of PDT is seriously hindered by many...

Cited by 6 publications

References 138 publications

Radioactive hybrid semiconducting polymer nanoparticles for imaging-guided tri-modal therapy of breast cancer

Radioactive hybrid semiconducting polymer nanoparticles for imaging-guided tri-modal therapy of breast cancer

Advanced Strategies for Strengthening the Immune Activation Effect of Traditional Antitumor Therapies

Metal‐Coordinated Polydopamine Structures for Tumor Imaging and Therapy

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