Nanoporous Anodic Alumina Surfaces Affect Fibro‐ and Osteoblasts in Opposite Ways

Taxis, Juergen; Moest, Tobias; Pedimonte, Birgit Joana; Schlegel, Karl Andreas; Neukam, Friedrich Wilhelm; Wilmowsky, Cornelius von

doi:10.1002/adem.201500305

Cited by 4 publications

(4 citation statements)

References 34 publications

(41 reference statements)

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“…Preliminary in vitro experiments with human fetal osteoblasts and fibroblasts have demonstrated that nanoporous anodic aluminum oxide surfaces with a pore diameter of 15 nm have a stimulating effect on the proliferation of fibroblasts and positively promote cell growth. Pores in the range of 40 nm, however, stimulated the growth behavior of osteoblasts while maintaining a vital morphology (Taxis et al, ). Precisely because active and coordinated growth of fibroblasts in the region of the implant shoulder after insertion is of immense importance in order to create a natural tissue barrier against the microbiota spectrum of the oral cavity, an implant surface at the gingival implantation site should combine the properties of excellent cell compatibility with an inhibitory character against bacterial adhesion.…”

Section: Discussionmentioning

confidence: 99%

“…Preliminary tests have shown that surfaces made of anodically modified aluminum oxide with different pore diameters in the nanometer range have an opposite effect on the growth behavior of osteoblasts and fibroblasts. Pore diameters in the range of 40 nm promote the growth of osteoblasts and could thus contribute to better bone healing of the implant body, whereas pores in the order of 15 nm would have a positive effect on the proliferation of fibroblasts and would thus be suitable for use in the area of the implant shoulder (Taxis et al, ).…”

Section: Introductionmentioning

confidence: 99%

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The influence of nanoporous anodic aluminum oxide on the initial adhesion of Streptococcus mitis and mutans

et al. 2019

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The use of nanoscale surface modifications offers a possibility to regulate the bacterial adherence behavior. The aim of this study was to evaluate the influence of nanoporous anodic aluminum oxide of different pore diameters on the bacterial species Streptococcus mitis and Streptococcus mutans. Nanoporous anodic aluminum oxide (AAO) surfaces with an average pore diameter of 15 and 40 nm, polished pure titanium and compact aluminum oxide (alumina) samples as reference material were investigated. S. mitis and mutans were evaluated for initial adhesion and viability after an incubation period of 30 and 120 min. After 30 min a significantly reduced growth of S. mitis and mutans on 15 nm samples compared to specimens with 40 nm pore diameter, alumina and titanium surfaces could be observed (p < .001). Even after 120 min incubation there was a significant difference between the surfaces with 15 nm pore diameter and the remaining samples (p < .001). AAO surfaces with a small pore diameter have an inhibitory effect on the initial adhesion of S. mitis and mutans. The use of such pore dimensions in the area of the implant shoulder represents a possibility to reduce the adhesion behavior of these bacterial species.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The influence of nanoporous anodic aluminum oxide on the initial adhesion of Streptococcus mitis and mutans

et al. 2019

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“…24 On the contrary, Taxis et al reported recently that fibroblasts and osteoblasts show opposing trends with the pore sizes of AAO in their proliferation behaviors. 31 Apparently, different types of cells show different behaviors on nanopores.…”

Section: Articlementioning

confidence: 99%

Viability Studies of Cells on Nanostructured Surfaces With Various Feature Sizes

Kim

Lee

et al. 2017

Bulletin Korean Chem Soc

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We demonstrate that the pore size of a nanoporous anodic aluminum oxide (AAO) membrane is critical for cell viability and cell adhesion upon HeLa cell growth on it, while other properties of membranes such as surface wettability and pore fraction show no such effects. After a human cancer cell, HeLa cell line, was seeded on AAO membranes with various pore sizes ranging from 18 to 150 nm, the adhered cell population and 3‐(4,5‐dimethyltiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay were measured. The cell adhesion and viability on the membrane with small pores (18 nm) were similar to those on the nonporous reference; however, they gradually decreased as the pore size increased. The decreased viability involves cell death as well as poor cell adhesion. We found that cyclo(l‐arginylglycyl‐l‐α‐aspartyl‐d‐phenylalanyl‐l‐cysteinyl), a well‐known integrin receptor antagonist, drastically decreased the cell adhesion to the membranes. The data indicate that the cell adhesion to the nanoporous membranes may be mediated by integrin on the cell surface, plausibly explaining the pore size dependence of the cell adhesion and viability. Implications of the present results to related fields such as implants are discussed.

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“…Bioinert ceramic coatings have predominantly been studied for enhancing hardness, wear, and corrosion resistance of hip joints . Some of the most commonly studied bioinert ceramics for coating femoral heads are nitrides, carbides, alumina, and zirconia because of their high strength, hardness, toughness, wear and corrosion resistance, and low coefficient of friction …”

Section: Introductionmentioning

confidence: 99%

Nitride, Zirconia, Alumina, and Carbide Coatings on Ti6Al4V Femoral Heads: Effect of Deposition Techniques on Mechanical and Tribological Properties

et al. 2017

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Ti6Al4V has been extensively studied in orthopedic applications because of its biocompatibility, desirable mechanical strength, and fatigue resistance. A wide range of bioinert ceramics have been investigated to further develop the tribological and mechanical properties of Ti6Al4V for the production of potential femoral heads. However, an analysis of the literature indicates that the performance of the coatings produced has been inconsistent. In this review, for the first-time deposition techniques of the most widely studied bioinert ceramics namely nitrides, carbides, zirconia, and alumina on Ti6Al4V substrates and their relevant mechanical and tribological performance have been analyzed. Finally, graphene has also been suggested for use together with bioinert ceramics due to its excellent mechanical and physical properties for coating Ti6Al4V femoral heads.

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Nanoporous Anodic Alumina Surfaces Affect Fibro‐ and Osteoblasts in Opposite Ways

Cited by 4 publications

References 34 publications

The influence of nanoporous anodic aluminum oxide on the initial adhesion of Streptococcus mitis and mutans

The influence of nanoporous anodic aluminum oxide on the initial adhesion of Streptococcus mitis and mutans

Viability Studies of Cells on Nanostructured Surfaces With Various Feature Sizes

Nitride, Zirconia, Alumina, and Carbide Coatings on Ti6Al4V Femoral Heads: Effect of Deposition Techniques on Mechanical and Tribological Properties

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