Nanoporous Biocompatible Layer on Ti–6Al–4V Alloys Enhanced Osteoblast-like Cell Response

Lee, Wei Fang; Yang, Tzu Sen; Wu, Yi Chieh; Peng, Pai

doi:10.1016/j.jecm.2013.04.002

Cited by 46 publications

(23 citation statements)

References 26 publications

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“…As reported in previous research studies, the nanoporous surface provides a biological environment for the growth of tissues around the implant and builds a strong biological interface and improved the implant stability [11]. The characteristics of surface morphology has greatly influenced by Si powder concentration.…”

Section: Resultsmentioning

confidence: 75%

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Experimental investigations in powder mixed electric discharge machining of Ti–35Nb–7Ta–5Zrβ-titanium alloy

Prakash

Kansal

Pabla

et al. 2016

Materials and Manufacturing Processes

184

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The present research is the first type of study, in which the application of powder mixed electrical discharge machining (PM-EDM) for the machining of β-phase titanium (β-Ti) alloy has been proposed. β-Ti alloys are new range of titanium alloys, which has wide spread application in dental, orthopaedics, shape memory, and stents. The aim of the present study is to fabricate submicro-and nano scale topography by PMEDM process to enhance the biocompatibility without affecting machining efficiency. The effect of Si powder concentration along with pulse-current and duration on the surface and machining characteristics has been investigated. A significant decrease in surface crack density on the machined surface with 4 g/l Si powder concentration was observed. When β-Ti alloy was modified at 15 A pulse-current, longer pulse interval with 8 g/l concentration of Si powder particles, the interconnected surface porosities with pore size 200-500 nm was observed. Moreover, at Si powder concentration of 2 and 4 g/l, the recast layer thickness is 8µm and 2-3 µm, respectively. Elemental mapping analysis confirmed that PMEDM also generated carbides and oxides enriched surface, a favourable surface chemistry to enhance the biocompatibility of β-Ti alloy. Furthermore, Downloaded by [George Mason University] at 06:41 22 June 2016 2 PMEDM also enhances the machining performance by improving MRR and reducing TWR.

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Section: Resultsmentioning

confidence: 75%

“…EDM also alter the surface chemistry of Ti-6Al-4V alloy into oxides and carbides, which is favourable for boneimplant anchorage [11]. The capability of EDM to enhance the surface hardness, wear resistance, corrosion resistance and bioactivity of Ti-6Al4V alloy by surface alloying has been reported by bin et al [12].…”

mentioning

confidence: 91%

Experimental investigations in powder mixed electric discharge machining of Ti–35Nb–7Ta–5Zrβ-titanium alloy

Prakash

Kansal

Pabla

et al. 2016

Materials and Manufacturing Processes

184

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“…The experimental researches are at initial stages regarding the surface modification through EDM in context of biocompatibility. EDM has been used for coating [26,34,35], particle migration [36,37], layer quality improvement [30,38,39], and nano-surface treatment [30,[40][41][42] for biomedical implants surface treatment of titanium alloys [43].…”

mentioning

confidence: 99%

On the Investigation of Surface Integrity of Ti6Al4V ELI Using Si-Mixed Electric Discharge Machining

et al. 2020

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Surface modification is given vital importance in the biomedical industry to cope with surface tissue growth problems. Conventionally, basic surface treatment methods are used which include physical and chemical deposition. The major drawbacks associated with these methods are excessive cost and poor adhesion of coating with implant material. To generate a bioactive surface on an implant, electric discharge machining (EDM) is a promising and emerging technology which simultaneously serves as machining and surface modification technique. Besides the surface topology, implant material plays a very important role in surgical applications. From various implant materials, titanium (Ti6Al4V ELI) alloy is the best choice for long-term hard body tissue replacement due to its superior engineering, excellent biocompatibility and antibacterial properties. In this research, EDM’s surface characteristics are explored using Si powder mixed in dielectric on Ti6Al4V ELI. The effect of powder concentration (5 g/L, 10 g/L and 20 g/L) along with pulse current and pulse on time is investigated on micro and nanoscale surface topography. Optimized process parameters having a 5 g/L powder concentration result in 2.76 μm surface roughness and 13.80 μm recast layer thickness. Furthermore, a nano-structured (50–200 nm) biocompatible surface is fabricated on the surface for better cell attachment and growth. A highly favourable carbon enriched surface is confirmed through EDS which increases adhesion and proliferation of human osteoblasts.

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“…Moreover, short duration pulses provide nano porous TiO 2 on EDM'ed titanium surface [2]. Yang et al, [3] and Lee et al, [4] have observed nanoscale pores in anatase TiO 2 surface when EDM of Ti-6Al-4V work material when using water as the dielectric liquid. Also, better biocompatible surfaces were obtained when using high pulse current and duration during EDM [5].…”

Section: Introductionmentioning

confidence: 99%

Ti6Al4V Surface Modification by Hydroxyapatite Powder Mixed Electrical Discharge Machining for Medical Applications

Öpöz

Yaşar

Murphy

et al. 2019

International Journal of Advances in Engineering and Pure Sciences

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Titanium surface modification by the Hydroxyapatite (HA) mixed Electrical Discharge Machining (EDM) is an alternative and promising technique to enhance the biocompatibility and to promote the biological performance in bone, which is dependent on surface properties, such as surface roughness, chemistry, and wettability. HA powder is used for the first time with electrical discharge machining to improve osteoblastic cell activity on the developed surfaces for Ti6Al4V. Different HA concentrations in deionized water were tested as an experimental variable during EDM. Abrasive polishing and electrical discharge machined control surfaces without powder addition also analyzed to compare the results. The surface characteristics of analyzed samples were evaluated by Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDS), X-Ray Diffractometry (XRD), white light interferometry, and contact angle measurements. The wettability tests suggest that the hydroxyapatite powder mixed EDM'ed surfaces shows highly hydrophilic characteristics compared the other surfaces, abrasive polished and EDM'ed without powder addition in the dielectric. The results from the MTT assay revealed that those surfaces modified using HA powder addition in distilled water dielectric liquid promoted the most significant cell attachment/growth. The results indicate that HA powder mixed EDM offers a promising method for the surface modification of biomaterials such as titanium alloys.

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Nanoporous Biocompatible Layer on Ti–6Al–4V Alloys Enhanced Osteoblast-like Cell Response

Cited by 46 publications

References 26 publications

Experimental investigations in powder mixed electric discharge machining of Ti–35Nb–7Ta–5Zrβ-titanium alloy

Experimental investigations in powder mixed electric discharge machining of Ti–35Nb–7Ta–5Zrβ-titanium alloy

On the Investigation of Surface Integrity of Ti6Al4V ELI Using Si-Mixed Electric Discharge Machining

Ti6Al4V Surface Modification by Hydroxyapatite Powder Mixed Electrical Discharge Machining for Medical Applications

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