2016
DOI: 10.1002/adfm.201604631
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Nanoporous Gold Biointerfaces: Modifying Nanostructure to Control Neural Cell Coverage and Enhance Electrophysiological Recording Performance

Abstract: Nanostructured neural interface coatings have significantly enhanced recording fidelity in both implantable and in vitro devices. As such, nano-porous gold (np-Au) has shown promise as a multifunctional neural interface coating due, in part, to its ability to promote nanostructure-mediated reduction in astrocytic surface coverage while not affecting neuronal coverage. The goal of this study is to provide insight into the mechanisms by which the np-Au nanostructure drives the differential response of neurons ve… Show more

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Cited by 64 publications
(83 citation statements)
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References 53 publications
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“…Ordered arrays of lithography fabricated nanopit substrates have been consistently shown in previous work to disrupt cell adhesion in vitro by direct or indirect modulation of focal adhesion formation . Recent in vitro studies exploring topographical modification have been successful in controlling astrocyte adhesion while promoting high neuron integration as strategies to reduce gliosis, with microscale isotropic pit topographies of 1 µm in depth reported to modulate astrocytes adhesion in vitro …”
Section: Introductionmentioning
confidence: 73%
“…Ordered arrays of lithography fabricated nanopit substrates have been consistently shown in previous work to disrupt cell adhesion in vitro by direct or indirect modulation of focal adhesion formation . Recent in vitro studies exploring topographical modification have been successful in controlling astrocyte adhesion while promoting high neuron integration as strategies to reduce gliosis, with microscale isotropic pit topographies of 1 µm in depth reported to modulate astrocytes adhesion in vitro …”
Section: Introductionmentioning
confidence: 73%
“…Local processes at the surface of the pores or at their interface with a fluid are exploited for applications in fields such as catalysis, [11,[47][48][49][50] sensing, [11,51,52] actuation (see below), optical switching, [140][141][142] electropumping for microfluidic devices, [143] integrated circuit contacting, [144] biological implants, [145][146][147][148] and as electrodes where a large surface area is needed. Local processes at the surface of the pores or at their interface with a fluid are exploited for applications in fields such as catalysis, [11,[47][48][49][50] sensing, [11,51,52] actuation (see below), optical switching, [140][141][142] electropumping for microfluidic devices, [143] integrated circuit contacting, [144] biological implants, [145][146][147][148] and as electrodes where a large surface area is needed.…”
Section: Properties and Applicationsmentioning
confidence: 99%
“…Many promising opportunities for using np metals as functional materials exploit the large specific surface area in the pore space. Local processes at the surface of the pores or at their interface with a fluid are exploited for applications in fields such as catalysis, [11,[47][48][49][50] sensing, [11,51,52] actuation (see below), optical switching, [140][141][142] electropumping for microfluidic devices, [143] integrated circuit contacting, [144] biological implants, [145][146][147][148] and as electrodes where a large surface area is needed. [149][150][151] In most instances, the function exploits the transport of mass and/or of electric signals in the form of ions through the open pore space.…”
Section: Properties and Applicationsmentioning
confidence: 99%
“…[21] However, this type of cleavage process is irreversible and therefore cannot be used dynamically.I nn ative tissues,c ells exhibit multiple transient interactions with the local ECM, especially during tissue morphogenesis,w ound healing, and cancer progression. [22,23] This need for dynamic control provides arationale for developing more tunable platforms.T here are several strategies for the reversible control of the biophysical properties of ECMs, [24][25][26][27][28] but in vitro cell culture platforms with reversible changes in the density of adhesion molecules remain elusive.Here,w ed escribe ap otential-responsive system to monitor and regulate cellular behavior in situ. We modify electrode surfaces and control the accessibility of the RGD peptide to the cells by exploiting charged end groups on afunctionalized self-assembled monolayer (SAM).…”
mentioning
confidence: 99%