2021
DOI: 10.3390/pharmaceutics13010063
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Nanoporous Silica Entrapped Lipid-Drug Complexes for the Solubilization and Absorption Enhancement of Poorly Soluble Drugs

Abstract: This study aims to examine the contribution of nanoporous silica entrapped lipid-drug complexes (NSCs) in improving the solubility and bioavailability of dutasteride (DUT). An NSC was loaded with DUT (dissolved in lipids) and dispersed at a nanoscale level using an entrapment technique. NSC microemulsion formation was confirmed using a ternary phase diagram, while the presence of DUT and lipid entrapment in NSC was confirmed using scanning electron microscopy. Differential scanning calorimetry and X-ray diffra… Show more

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Cited by 9 publications
(8 citation statements)
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“…All data were expressed as mean ± standard deviation and analyzed using Student's t-test to compare the means of the two groups, or analysis of variance (ANOVA) to evaluate the impact of one or more factors, including the formulation, period, and sequence of crossbar layout for administration, on the pharmacokinetic parameters as fixed effects and a random selection effect of subjects nested within the sequence [43]. Statistical significance was set at p < 0.05.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…All data were expressed as mean ± standard deviation and analyzed using Student's t-test to compare the means of the two groups, or analysis of variance (ANOVA) to evaluate the impact of one or more factors, including the formulation, period, and sequence of crossbar layout for administration, on the pharmacokinetic parameters as fixed effects and a random selection effect of subjects nested within the sequence [43]. Statistical significance was set at p < 0.05.…”
Section: Discussionmentioning
confidence: 99%
“…Drug delivery systems are used to improve the solubility and increase the bioavailability of poorly water-soluble drugs [43][44][45][46][47][48][49][50][51][52][53]. Numerous techniques have been developed in recent years to enhance the oral bioavailability of poorly water-soluble drugs, including mesoporous silica, microemulsions [54], self-nano-emulsifying drug delivery systems [55], lyotropic liquid crystalline nanoparticles, and chitosan nanoparticles [56].…”
Section: Introductionmentioning
confidence: 99%
“…After overlapping the contour maps of each response, response surface methods were used to identify the ideal window of the operability design space according to the acceptable range and failure edges with relation to the individual goals [25].…”
Section: Development Of the Design Spacementioning
confidence: 99%
“…Compressibility index between 10 and 30 indicates good flowability and angle of repose below 40° is acceptable. 59…”
Section: Characterization Of Uncoated F7-smcc and Coated C1-smcc Powders Micrometric Propertiesmentioning
confidence: 99%
“…Uncoated F7-SMCC and coated C1-SMCC showed insignificant difference (P<0.05) in percent drug content of the different quantities of the powder, indicating homogenous distribution of the drug throughout the powder. 59 In vitro Dissolution Study of Uncoated F7-SMCC and Coated C1-SMCC Powders Figure 7 manifests the dissolution profiles of CC from uncoated F7-SMCC and coated C1-SMCC powders compared with free CC, in different gastrointestinal physiological pH values. Different parameters could control the drug release such as the solubility of the drug, the solubility of CS coat, pH of the dissolution medium, and PS of the niosomes.…”
Section: Drug Content Homogeneitymentioning
confidence: 99%