Nanoporous Silicon Composite as Potential System for Sustained Delivery of Florfenicol Drug

Abstract

Nanostructured porous silicon (nPSi) is a nanostructured biomaterial which has received considerable attention in biomedical applications due to its biocompatibility, biodegradability, high surface area, and the ease to modify its surface chemistry. In the present work, nPSi composite microparticles are evaluated as potential drug delivery system. nPSi layers are formed by electrochemical etching of silicon wafers in hydrofluoric acid solutions. This fabrication process allows modifying the main properties of nPSi layers, including the porosity, average pore size and pore shape, by simply controlling the main parameters in the process, such as the applied current density and the electrolyte composition. nPSi microparticles are prepared from the removal and fracture by ultrasound sonication of nPSi layers. Composites are obtained from oxidized nPSi (nPSi-Ox) microparticles cascade processed with chitosan (CHI) and β-cyclodextrin (βCD) biopolymers. Samples are evaluated as drug delivery system using florfenicol (FF) as model drug, due to its economical and sanitary importance in salmon industry. Drug loaded and release kinetic tests are performed in different media: distilled water and simulated seawater. Initial data show that nPSi-βCD composites allow a mayor control in the drug time release kinetic compared to nPSi-Ox microparticles.

Use of nPSi-βCD Composite Microparticles for the Controlled Release of Caffeic Acid and Pinocembrin, Two Main Polyphenolic Compounds Found in a Chilean Propolis

“…However, for the release of CA using nPSi-βCD, CA release kinetics were described with a more accurate precision by the Korsmeyer-Peppas model. This means that the governing factor of CA release was not the dissolution from samples, but a Fickian diffusion process [41]. Moreover, in that sense, since the release exponent n from the Korsmeyer-Peppas model was smaller than 0.5, only diffusive release can be suggested.…”

“…Moreover, in that sense, since the release exponent n from the Korsmeyer-Peppas model was smaller than 0.5, only diffusive release can be suggested. Therefore, erosion process could be insignificant [41]. For the case of Pin, both release profiles from nPSi and nPSi-βCD microparticles, were better adjusted to the Korsmeyer-Peppas model.…”

“…However, nPSi presented an n value closed to zero. Regarding nPSi-βCD, it showed an n > 0.5, which suggest that besides Fickian diffusion, erosion process could also be contributing in the Pin release [41].…”

“…Oxidized nPSi microparticles were the substrate to synthetize the composite according to the protocol of Hernandez-Montelongo et al [41] (Figure 1B). nPSi microparticles were immersed in a Chi solution for 15 min and after rinsed with EtOH (nPSi-CHI).…”

Coatings of Cyclodextrin/Citric-Acid Biopolymer as Drug Delivery Systems: A Review

“…Among implants are several plastic devices like PVDF membranes for periodontology [ 54 , 55 ], polyester vascular prostheses [ 56 ], polyamide inguinal meshes [ 57 ], polypropylene meshes for the treatment of hernias [ 59 ], poly(2-hydroxyethyl methacrylate) contact lenses [ 32 ], PET textiles [ 9 , 61 , 62 , 70 ], meshes [ 44 ], and vascular prostheses [ 68 ], PLLA parietal reinforcement [ 66 ], and PTT textiles [ 72 ]. Organic and inorganic materials have been used as substrates for the CD/CTR coatings, such as cellulose papers [ 60 , 63 , 65 ], hydroxyapatite [ 58 ], porous silicon [ 10 , 67 , 69 , 73 ], and zeolite [ 34 ]. Metal medical devices include titanium disks [ 8 ], CoCr [ 64 ], and NiTiNOL stents [ 71 ].…”