Nanoporous tantalum coated zirconia implant improves osseointegration

Wu, Lianjun; Dong, Yaru; Yao, Litao; Liu, Chuantong; Al-Bishari, Abdullrahman M.; Yie, Kendrick Hii Ru; Zhang, Hualin; Liu, Jinsong; Wu, Gang

doi:10.1016/j.ceramint.2020.04.038

Cited by 19 publications

(8 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, tantalum (Ta) and its oxides have emerged as excellent materials, exhibiting biocompatibility, anti-corrosion performance, and osteoinductivity ( Bencharit et al, 2014 ). Compared with the surface structure, the release of the Ta ions plays a pivotal role in osteogenic promotion, as has been confirmed in previous studies ( Wang et al, 2015 ; Wu et al, 2020 ). Tantalum shows remarkable physicochemical stability and superior cytocompatibility, which have been confirmed can stimulate the proliferation and osteogenesis of osteoblasts ( Bencharit et al, 2014 ).…”

Section: Introductionsupporting

confidence: 78%

“…The cell morphology was performed after seeding cells (1 × 10 4 cells/well) on 24 well plates. The cell morphology was characterized by cell staining at precise time durations, according to the previous study ( Wu et al, 2020 ). In order to better observe the cell morphology, the samples were placed after the cell seeding procedure.…”

Section: Methodsmentioning

confidence: 99%

“…Compared with HA, FHA can be easily coated onto the biodegradable Mg substrates by electrochemical deposition. In addition, FHA is more stable, along with having a low dissolution, and high cell response ( Ma et al, 2014 ; Wang et al, 2015 ; Wu et al, 2020 ). Therefore, the synthesis of FHA on the Mg implant surface represents a potential method to optimize osteogenic differentiation.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Osteoinduction Evaluation of Fluorinated Hydroxyapatite and Tantalum Composite Coatings on Magnesium Alloys

Cao

Yang

et al. 2021

Front. Chem.

Self Cite

View full text Add to dashboard Cite

Magnesium (Mg) alloys have a wide range of biomaterial applications, but their lack of biocompatibility and osteoinduction property impedes osteointegration. In order to enhance the bioactivity of Mg alloy, a composite coating of fluorinated hydroxyapatite (FHA) and tantalum (Ta) was first developed on the surface of the alloy through thermal synthesis and magnetron sputtering technologies in this study. The samples were characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), energy dispersive spectroscopy (EDS) mapping, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and water contact angle measurement (WCA), which characterized the surface alternation and confirmed the deposition of the target FHA/Ta coating. The results of cell morphology showed that the MC3T3-E1 cells on the surface of Mg/FHA/Ta samples had the largest spreading area and lamellipodia. Moreover, the FHA coating endowed the surface with superior cell viability and osteogenic properties, while Ta coating played a more important role in osteogenic differentiation. Therefore, the combination of FHA and Ta coatings could synergistically promote biological functions, thus providing a novel strategy for implant design.

show abstract

Section: Introductionsupporting

confidence: 78%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Osteoinduction Evaluation of Fluorinated Hydroxyapatite and Tantalum Composite Coatings on Magnesium Alloys

Cao

Yang

et al. 2021

Front. Chem.

Self Cite

View full text Add to dashboard Cite

show abstract

“…As stated previously for the cellular proliferation experiments, the increased nanostructured roughness provided by the NT and NC samples could be attributed to the enhanced osteogenic differentiation of hADMSCs. This result is in line with the literature where nanostructured roughness was shown to induce osteogenic differentiation of hMSCs on anodized titanium and titanium alloy surfaces. , In fact, nanostructured surface topography alone was shown to induce osteogenic differentiation even when osteogenic induction medium was not used during cell culture (no dexamethasone or ascorbic acid was supplied into the cell culture media). , That said, anodized nanoporous tantalum coated implants demonstrated improved osteogenic differentiation and induced bone formation in rabbit models . Apart from the roughness, the surface energy of the samples could have contributed to the observed differences in the gene expression of hADMSCs.…”

Section: Results and Discussionmentioning

confidence: 99%

“…54,55 That said, anodized nanoporous tantalum coated implants demonstrated improved osteogenic differentiation and induced bone formation in rabbit models. 56 Apart from the roughness, the surface energy of the samples could have contributed to the observed differences in the gene expression of hADMSCs. Specifically, surface energy and hydrophilicity of the NT samples increased after the anodic oxidation process, which plays a critical role in protein adsorption.…”

Section: In Vitro Experimentsmentioning

confidence: 99%

Morphology of Nanostructured Tantalum Oxide Controls Stem Cell Differentiation and Improves Corrosion Behavior

Erdogan,

Uslu,

Aydınol

et al. 2023

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Tantalum is receiving increasing attention in the biomedical field due to its biocompatible nature and superior mechanical properties. However, the bioinert nature of tantalum still poses a challenge and limits its integration into the bone tissue. To address these issues, we fabricated nanotubular (NT), nanocoral (NC), and nanodimple morphologies on tantalum surfaces via anodization. The size of these nanofeatures was engineered to be approximately 30 nm for all anodized samples. Thus, the influence of the anodized nanostructured morphology on the chemical and biological properties of tantalum was evaluated. The NT and NC samples exhibited higher surface roughness, surface energy, and hydrophilicity compared to the nonanodized samples. In addition, the NT samples exhibited the highest corrosion resistance among all of the investigated samples. Biological experiments indicated that NT and NC samples promoted human adipose tissue-derived mesenchymal stem cell (hADMSC) spreading and proliferation up to 5 days in vitro. ALP, COL1A1, and OSC gene expressions as well as calcium mineral synthesis were upregulated on the NT and NC samples in the second and third weeks in vitro. These findings highlight the significance of nanostructured feature morphology for anodized tantalum, where the NT morphology was shown to be a potential candidate for orthopedic applications.

show abstract

Nanotubular ZrTiO₄ Prepared on Sputter Deposited Zr−Ti Films by Anodization

Zhao

et al. 2021

ChemElectroChem

View full text Add to dashboard Cite

Highly ordered nanotubular ZrTiO4 thin films were synthesized by directly anodizing co‐sputtered Zr−Ti films deposited on silicon substrates. The crystals of as‐deposited Zr−Ti films preferred (002) orientation was beneficial to the nanotubular structure formation. The adjusted anodization potential and composition of Zr−Ti films resulted in a controllable nanotube diameter that ranges from approximately 45 nm to 110 nm. The thickness of as‐deposited Zr−Ti films and growth rates determined the length of nanotubular structure (1.7–4.5 μm). The decreased Ti content in the deposited Zr−Ti films lead to a higher nanotube growth rate due to the lower binding energy of Ti and oxygen. The higher Zr content in the Zr−Ti films was responsible for the crystalized nanotubular ZrTiO4 after anodization.

show abstract

Nanoporous tantalum coated zirconia implant improves osseointegration

Cited by 19 publications

References 54 publications

Osteoinduction Evaluation of Fluorinated Hydroxyapatite and Tantalum Composite Coatings on Magnesium Alloys

Osteoinduction Evaluation of Fluorinated Hydroxyapatite and Tantalum Composite Coatings on Magnesium Alloys

Morphology of Nanostructured Tantalum Oxide Controls Stem Cell Differentiation and Improves Corrosion Behavior

Nanotubular ZrTiO₄ Prepared on Sputter Deposited Zr−Ti Films by Anodization

Contact Info

Product

Resources

About

Nanoporous tantalum coated zirconia implant improves osseointegration

Cited by 19 publications

References 54 publications

Osteoinduction Evaluation of Fluorinated Hydroxyapatite and Tantalum Composite Coatings on Magnesium Alloys

Osteoinduction Evaluation of Fluorinated Hydroxyapatite and Tantalum Composite Coatings on Magnesium Alloys

Morphology of Nanostructured Tantalum Oxide Controls Stem Cell Differentiation and Improves Corrosion Behavior

Nanotubular ZrTiO4 Prepared on Sputter Deposited Zr−Ti Films by Anodization

Contact Info

Product

Resources

About

Nanotubular ZrTiO₄ Prepared on Sputter Deposited Zr−Ti Films by Anodization