Nanoprecipitation for Poorly Water-Soluble Drugs

Nguyen, Tuong Ngoc-Gia; Tran, Van-Thanh; Duan, Wei; Tran, Phuong Ha-Lien; Tran, Thao

doi:10.2174/1389200218666171004112122

Cited by 15 publications

(7 citation statements)

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“…Basically, a polymer solution is electro-sprayed through a nozzle into droplets which are collected in a water solution with mixing to induce nanoprecipitation, and very uniform polymeric NPs can be generated . Similarly, other process intensification strategies can be combined with nanoprecipitation to intensify the mixing process thus forming better controlled NPs, such as heat-induced evaporative antisolvent nanoprecipitation (HIEAN), , sonication-assisted nanoprecipitation, dialysis-based nanoprecipitation, , temperature-assisted nanoprecipitation (TAN), or using a helically coiled tubular device (HCTD). , …”

Section: Nanoprecipitationmentioning

confidence: 99%

“…Many marketed drugs and active pharmaceutical ingredients are poorly water soluble. The poor water solubility of these drugs limits their dissolution rate and led to low bioavailability, thus hindering their applications as effective therapeutic drugs. − One of the widely used approaches to increase the solubility of poorly water-soluble drugs and thus their bioavailability is to formulate them into NPs as the dissolution rate is proportional to their surface area, which in turn affects profoundly their bioavailability. Polymeric nanocarriers are widely used in drug delivery because they not only protect the encapsulated drug from their surrounding environment in vivo but they also control the release of the encapsulated drug .…”

Section: Different Types Of Nanoparticles By Nanoprecipitationmentioning

confidence: 99%

“…Nanoprecipitation has been explored to formulate a wide range of hydrophobic components including hydrophobic drugs, polymers, hydrophobic proteins, etc. It has been reported that about 40% of clinically approved drugs and 90% of drugs under development are hydrophobic with low water solubility. − Therefore, nanoprecipitation serves as a powerful tool to formulate these hydrophobic drugs. Formulating hydrophobic drugs into nanoparticles provides several advantages, including the following: (1) Drug nanoparticles can improve the solubility and dissolution rate of insoluble drugs, thus enhancing their bioavailability.…”

Section: Introductionmentioning

confidence: 99%

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Formulation of Nanoparticles Using Mixing-Induced Nanoprecipitation for Drug Delivery

Liu

Yang

Zou

et al. 2019

Ind. Eng. Chem. Res.

137

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Significant efforts have been made to fabricate drug-loaded nanoparticles for drug delivery. Nanoprecipitation is a simple and versatile method for making various types of polymer nanoparticles with well-controlled particle size, size distribution, and surface properties. This review presents a critical overview of three different widely used nanoprecipitation techniques, namely, traditional nanoprecipitation in bulk solutions, flash nanoprecipitation, and microfluidic-based nanoprecipitation. The review starts with the comparison of these three different nanoprecipitation methods summarizing their key characteristics, advantages, and disadvantages. Then, different types of nanoparticles synthesized using nanoprecipitation are presented including di-block copolymer nanoparticles and natural polymer nanoparticles. A special focus is placed on comparing different drug-loaded polymer nanoparticles prepared using different nanoprecipitation approaches including their synthesis methods, drug loading, encapsulation efficiency, nanoparticle properties (e.g., size, PDI, etc.), and stability. Finally, the principle of forming nanoparticles with well-controlled properties is discussed to fundamentally understand the intricate interplay between mixing, supersaturation, nucleation, and particle growth, aiming to provide a general guideline for making drug-loaded nanoparticles based on nanoprecipitation.

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Section: Nanoprecipitationmentioning

confidence: 99%

Section: Different Types Of Nanoparticles By Nanoprecipitationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Formulation of Nanoparticles Using Mixing-Induced Nanoprecipitation for Drug Delivery

Liu

Yang

Zou

et al. 2019

Ind. Eng. Chem. Res.

137

View full text Add to dashboard Cite

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“…With the development of hydrogel nanoparticles with many applications and the benefits of nanoparticles, there is also a great opportunity for the inclusion of other types of nanoparticle research in FFSs [124,125,126,127,128,129,130,131,132,133,134,135,136]. For example, a future study will provide a detailed understanding of how nanosized drugs can be incorporated and stabilized in FFSs and be delivered effectively to targeted sites.…”

Section: Formulation Design Of Controlled Drug Release Film-forminmentioning

confidence: 99%

Controlled Release Film Forming Systems in Drug Delivery: The Potential for Efficient Drug Delivery

Tran

2019

Pharmaceutics

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Despite many available approaches for transdermal drug delivery, patient compliance and drug targeting at the desired concentration are still concerns for effective therapies. Precise and efficient film-forming systems provide great potential for controlling drug delivery through the skin with the combined advantages of films and hydrogels. The associated disadvantages of both systems (films and hydrogels) will be overcome in film-forming systems. Different strategies have been designed to control drug release through the skin, including changes to film-forming polymers, plasticizers, additives or even model drugs in formulations. In the current review, we aim to discuss the recent advances in film-forming systems to provide the principles and review the methods of these systems as applied to controlled drug release. Advances in the design of film-forming systems open a new generation of these systems.

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“…These drugs require extensive research to improve their bioavailability due to low absorption or non-targeted delivery. Therefore, a number of strategies, such as solid dispersions, emulsions, prodrugs, and nanoparticles, have been investigated to improve the therapeutic index of poorly water-soluble drugs [6,7,8,9,10,11]. Nanotechnology applications in medicine have grown enormously, attracting researchers worldwide.…”

Section: Introductionmentioning

confidence: 99%

Nanoconjugation and Encapsulation Strategies for Improving Drug Delivery and Therapeutic Efficacy of Poorly Water-Soluble Drugs

Tran

2019

Pharmaceutics

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Nanoconjugations have been demonstrated to be a dominant strategy for drug delivery and biomedical applications. In this review, we intend to describe several strategies for drug formulation, especially to improve the bioavailability of poorly water-soluble molecules for future application in the therapy of numerous diseases. The context of current studies will give readers an overview of the conjugation strategies for fabricating nanoparticles, which have expanded from conjugated materials to the surface conjugation of nanovehicles. Moreover, nanoconjugates for theranostics are also discussed and highlighted. Overall, these state-of-the-art conjugation methods and these techniques and applications for nanoparticulate systems of poorly water-soluble drugs will inspire scientists to explore and discover more productive techniques and methodologies for drug development.

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Nanoprecipitation for Poorly Water-Soluble Drugs

Abstract: In this review, nanoprecipitation methods and solvent removal techniques for poorly water soluble drugs will be discussed.

Cited by 15 publications

References 0 publications

Formulation of Nanoparticles Using Mixing-Induced Nanoprecipitation for Drug Delivery

Formulation of Nanoparticles Using Mixing-Induced Nanoprecipitation for Drug Delivery

Controlled Release Film Forming Systems in Drug Delivery: The Potential for Efficient Drug Delivery

Nanoconjugation and Encapsulation Strategies for Improving Drug Delivery and Therapeutic Efficacy of Poorly Water-Soluble Drugs

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