Nanoreactor based on Cu nanoparticles confined in B, N co-doped porous carbon nanotubes for glutathione biosensing

Yu, Liang; Yan, Xin; Li, Luo; Xing, Yue; Zhao, Puyu; Liu, Meihan; Zhu, Yicheng; Liu, Ning; Zhang, Zhiquan

doi:10.1007/s00604-023-05893-x

Cited by 3 publications

(1 citation statement)

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“…Therefore, the simultaneous detection of Epi and GSH can provide more information for further study of pheochromocytoma, thereby assisting the clinic in reducing the rate of misdiagnosis. Currently, several assays have been developed to detect Epi and GSH, including high-performance liquid chromatography–mass spectrometry methods, fluorescence methods, and electrochemical methods; these methods tend to involve complex sample preparation, are time-consuming, and costly, mostly not conducive to rapid on-site testing, especially in remote areas. However, colorimetric biosensors have garnered significant attention attributable to their cost-effectiveness, ease of operation, and significant color change in the reaction. − …”

Section: Introductionmentioning

confidence: 99%

Co/Mn-Doped Oxide Nanosheets with Dual Enzyme-Like Activity for Early Visual Diagnosis of Pheochromocytoma

Xu,

Wang,

Wang

et al. 2024

ACS Appl. Nano Mater.

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Pheochromocytoma may be overlooked or misdiagnosed in its early stages, resulting in serious clinical consequences. To comprehensively and accurately diagnose pheochromocytoma, we established a smartphone-assisted colorimetric sensing platform for the determination of two biomarkers of pheochromocytoma: epinephrine (Epi) and glutathione (GSH). In this article, Co/Mndoped oxide nanosheets (CoMnNSs) with oxidase-like and laccase-like activities have been synthesized via a one-step process. Compared to MnO 2 nanosheets (MnO 2 NSs), CoMnNSs have stronger catalytic activity due to the doping of the transition metal Co. Under optimal conditions, the oxidase-like and laccase-like activities of CoMnNSs were utilized for the determination of GSH and Epi, respectively, and the assay could be completed within 3 min, with the limits of detection (LOD) of 0.15 and 0.52 μM, respectively. Besides, the practicability of the established approach was confirmed in human serum samples with satisfactory recoveries. The experimental results indicated that the designed sensor demonstrated excellent sensitivity and selectivity. Thus, this work not only widens the idea for early visual diagnosis of pheochromocytoma but also confirms the effectiveness of the transition-metal doping strategy, which offers a simple, economical, and gentle means of modulating nanozyme activity.

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