Nanoreactor of sarcosine oxidase-embedded ZIFs activates fluorescent response for diagnosis of prostate cancer

Abstract

Sarcosine is one of the important markers in the diagnosis of prostate cancer. It is essential to explore a method detecting sarcosine in biological samples quickly and accurately for early...

A highly sensitive Zr-MOF mediated multi-enzyme cascade platform for the colorimetric and fluorescent dual-signal determination of sarcosine

“…However, although the method immobilized SOX, the HRP used in the system was still in a free state. 28 Gao et al proposed a new strategy for precise construction of micro mesopores to immobilize highly stable hierarchical porous metal-organic framework (HP-Zr-MOF) channel structures for HRP and glucose oxidase, which realized the rapid detection of glucose. 29 Inspired by the aforementioned studies, as shown in Scheme 1, we utilized Zr-MOFs with peroxidase-like activity to co-encapsulate SOX as well as HRP within the metal-organic framework.…”

“…However, although the method immobilized SOX, the HRP used in the system was still in a free state. 28 Gao et al proposed a new strategy for precise construction of micro mesopores to immobilize highly stable hierarchical porous metal–organic framework (HP-Zr-MOF) channel structures for HRP and glucose oxidase, which realized the rapid detection of glucose. 29…”