Nanorod-like Structure of ZnO Nanoparticles and Zn8O8 Clusters Using 4-Dimethylamino Benzaldehyde Liquid to Study the Physicochemical and Antimicrobial Properties of Pathogenic Bacteria

Ramesh, Sivalingam; Karthikeyan, C; Hameed, A.S. Haja; Afsar, N; Sivasamy, A.; Lee, Young-Jun; Kim, Do Kyung; Kim, Heung-Soo

doi:10.3390/nano13010166

Cited by 3 publications

(3 citation statements)

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“…The NPs' activity could be initiated in two ways: by directly or electrostatically interacting with the NPs and causing injury to the bacterial cell wall's outer membrane [53]. Second, producing ROS involves the formation of H 2 O 2 and the release of zinc ions into a bacterium-infested environment, which is toxic [54,55]. An earlier study found that hybrid ZnO NPs had exceptional antibacterial properties, which corroborate the current study's findings [56].…”

Section: Discussionsupporting

confidence: 85%

Synthesis and characterization of 4‐nitro benzaldehyde with ZnO‐based nanoparticles for biomedical applications

Indumathi,

Kumaresan,

Suriyaprakash

et al. 2023

J Basic Microbiol

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Globally, cancer is the leading cause of death and morbidity, and skin cancer is the most common cancer diagnosis. Skin problems can be treated with nanoparticles (NPs), particularly with zinc oxide (ZnO) NPs, which have antioxidant, antibacterial, anti‐inflammatory, and anticancer properties. An antibacterial activity of zinc oxide nanoparticles prepared in the presence of 4‐nitrobenzaldehyde (4NB) was also tested in the present study. In addition, the influence of synthesized NPs on cell apoptosis, cell viability, mitochondrial membrane potential (MMP), endogenous reactive oxygen species (ROS) production, apoptosis, and cell adhesion was also examined. The synthesized 4‐nitro benzaldehyde with ZnO (4NBZnO) NPs were confirmed via characterization techniques. 4NBZnO NPs showed superior antibacterial properties against the pathogens tested in antibacterial investigations. As a result of dose‐based treatment with 4NBZnO NPs, cell viability, and MMP activity of melanoma cells (SK‐MEL‐3) cells were suppressed. A dose‐dependent accumulation of ROS was observed in cells exposed to 4NBZnO NPs. As a result of exposure to 4NBZnO NPs in a dose‐dependent manner, viable cells declined and apoptotic cells increased. This indicates that apoptotic cell death was higher. The cell adhesion test revealed that 4NBZnO NPs reduced cell adhesion and may promote apoptosis of cancer cells because of enhanced ROS levels.

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Section: Discussionsupporting

confidence: 85%

Synthesis and characterization of 4‐nitro benzaldehyde with ZnO‐based nanoparticles for biomedical applications

Indumathi,

Kumaresan,

Suriyaprakash

et al. 2023

J Basic Microbiol

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“…The X-ray diffraction (XRD) was used to analyze the crystal structure of the ZnMOF powder. Figure 1 G showed the XRD patterns of ZnMOF particles, the standard diffraction peaks of which are consistent with the crystalline nature of zinc crystals 43 , suggesting the successful synthesis of ZnMOF with an integral crystal structure. Besides, the absorption profile of the ZnMOF solution also shows a characteristic peak at 430 nm (Figure 1 H-I), consistent with that of curcumin 44 .…”

Section: Resultssupporting

confidence: 54%

Curcumin-zinc framework encapsulated microneedle patch for promoting hair growth

Yang¹,

Wang²,

Gong³

et al. 2023

Theranostics

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Hair loss is a growing esthetic condition driven by complex mechanisms that has numerous psycho-social implications. Conventional drug applications usually focus on a single treatment target, and the penetration depth restricts the post-delivery effect. Method: We fabricated a curcumin-zinc framework (ZnMOF) encapsulated gamma-polyglutamic acid (γ-PGA) microneedle patch (ZnMOF-MN) as a multifunctional biosafe transdermal drug delivery system. ZnMOF was characterized with the field emission scanning electron microscope (FE-SEM), dynamic light scattering (DLS), elemental mapping, and X-ray diffraction (XRD). The topographical and hygroscopic features of ZnMOF-MN were characterized with SEM. The in vitro ZnMOF release profile and the in vivo penetration of ZnMOF-MN were also evaluated. The anti-oxidant, anti-apoptosis, and antiandrogen effects of ZnMOF solution and ZnMOF-MN extract were studied on mouse dermal papilla cells (DPCs). Two animal models (in C57BL/6 mice), including androgenic alopecia (AGA) model and wound healing model, were used to identify the therapeutic effect of ZnMOF-MN on hair regrowth and wound healing in vivo . Hair follicles, surrounding vessels (CD31+), and proliferating cells (Ki67+) were evaluated by histological staining. Results: ZnMOF crystals were cone-shaped nanoparticles with a size distribution of 424.9 ± 59.01 nm. ZnMOF-MN patch can create temporary holes in the skin to directly and evenly deliver bioactive ZnMOF particles to the targeted depth and achieve a steady and sustained release of Zn 2+ and curcumin. In vitro , ZnMOF significantly improved the viability of DPCs against the excess reactive oxygen species (ROS) and inhibited the apoptosis induced by zinc deficiency. In addition, it also reversed the inhibitory effects of dihydrotestosterone (DHT) infiltration. Moreover, the ZnMOF-MN treatment has been proved to accelerate wound healing and increase hair follicles in wound healing models, and improved the hair regrowth in AGA animal models. Enhanced capillary density and cell proliferation observed in the CD31+ and Ki67+ staining of ZnMOF-MN group in both animal models also suggested that ZnMOF can facilitate angiogenesis and promote cell proliferation in the skin, respectively. Conclusion: The ZnMOF-MN treatment is a comprehensive solution with excellent therapeutic efficacy and patient-friendly features for promoting hair growth under various clinical conditions.

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“…The maximum absorption depends on the NP morphology, dimensions, and surface microstructure. A broad absorption peak centered at approximately 390 nm was the characteristic of the Semal-ZnO NP formation in the range of 350–400 nm and was attributed to the binding of various capping molecules with the ZnO NPs, resulting in increased bandgap ( Figure 1A ) ( Abdelbaky et al, 2022 ; Sharma et al, 2022 ; Ramesh et al, 2023 ). The absorption peak observed in this study may be attributed to the intrinsic bandgap formed by electron transitions from the valence band (E V ) to the conduction band (E C ) of the Semal-ZnO NPs ( Mageswari et al, 2023 ).…”

Section: Resultsmentioning

confidence: 99%

Green route to fabrication of Semal-ZnO nanoparticles for efficient solar-driven catalysis of noxious dyes in diverse aquatic environments

Lal,

Gour,

Dave

et al. 2024

Front. Chem.

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This work successfully demonstrates a sustainable and environmentally friendly approach for synthesizing Semal-ZnO nanoparticles (NPs) using the aqueous leaf extract of Bombax ceiba L. These NPs exhibit an absorption peak at approximately 390 nm in the UV-visible spectrum and an energy gap (Eg) of 3.11 eV. Detailed analyses of the morphology and particle size using various spectroscopic and microscopic techniques, XRD, FE-SEM with EDS, and HR-TEM reveal crystallographic peaks attributable to the hexagonal phase, with an average crystal size of 17 nm. The Semal-ZnO NPs also exhibit a notable photocatalytic efficiency for degrading methylene blue (MB) and methyl orange (MO) under sunlight in different water samples collected from diverse natural sources, indicating that they are promising photocatalysts for environmental remediation. The photocatalytic efficiency of the biofabricated Semal-ZnO NPs is impressive, exhibiting a photodegradation rate of up to 99% for MB and 79% for MO in different water samples under exposure to sunlight. The novel phytofabricated Semal-ZnO NPs are thus a beacon of hope for the environment, with their desirable photocatalytic efficiency, pseudo-first-order kinetics, and ability to break down noxious dye pollutants in various aquatic environments.

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Nanorod-like Structure of ZnO Nanoparticles and Zn8O8 Clusters Using 4-Dimethylamino Benzaldehyde Liquid to Study the Physicochemical and Antimicrobial Properties of Pathogenic Bacteria

Cited by 3 publications

References 50 publications

Synthesis and characterization of 4‐nitro benzaldehyde with ZnO‐based nanoparticles for biomedical applications

Synthesis and characterization of 4‐nitro benzaldehyde with ZnO‐based nanoparticles for biomedical applications

Curcumin-zinc framework encapsulated microneedle patch for promoting hair growth

Green route to fabrication of Semal-ZnO nanoparticles for efficient solar-driven catalysis of noxious dyes in diverse aquatic environments

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