2012
DOI: 10.1021/ma3015992
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Nanorods Formed from a New Class of Peptidomimetics

Abstract: Although peptide amphiphiles have been explored as nanomaterials for different applications, nanostructures formed by hierarchical molecular assembly of sequencespecific peptidomimetics are much less developed. Such protein-like nanomaterials could enhance the current application of peptide-based amphiphiles by enriching the diversity of nanostructures, increasing in vivo stability for biomedical applications, and facilitating the understanding of biomacromolecular self-assembly. Herein we present a biomimetic… Show more

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Cited by 21 publications
(18 citation statements)
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References 30 publications
(54 reference statements)
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“…[3a, 18] Since di-alkylated hybrid peptides are very hydrophobic, it is possible that they form stable micelle structures in an aqueous environment. [19] This strong hydrophobic interaction may prevent micelle dissociation even while interacting with bacterial membranes. As a result, we hypothesize that these peptides are only weakly capable of penetrating bacterial membranes.…”
Section: Resultsmentioning
confidence: 99%
“…[3a, 18] Since di-alkylated hybrid peptides are very hydrophobic, it is possible that they form stable micelle structures in an aqueous environment. [19] This strong hydrophobic interaction may prevent micelle dissociation even while interacting with bacterial membranes. As a result, we hypothesize that these peptides are only weakly capable of penetrating bacterial membranes.…”
Section: Resultsmentioning
confidence: 99%
“…[15] Furthermore, g-AApeptides can also form novel nanostructures akin to peptide-based biomaterials. [16] The emerging importance of g-AApeptides has heightened the interest in the folding propensity regarding biomolecular structure.…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, γ-AApeptide mimics of RGD peptides (including 64 Cu-labelled compounds) [ 268 ], and of fMLF [ 269 ] (a selective formyl peptide receptor agonist) have been reported. In addition, γ-AApeptides have been shown to disrupt Aβ aggregation in Alzheimer’s disease [ 270 ], and to have potential applications in biomaterial science [ 271 ].…”
Section: Peptidomimeticsmentioning
confidence: 99%