2023
DOI: 10.3389/fbioe.2023.1036125
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Nanoscale borosilicate bioactive glass for regenerative therapy of full-thickness skin defects in rabbit animal model

Abstract: Bioactive glass (BG) occupies a significant position in the field of hard and soft tissue regeneration. Different processing techniques and formulas have been introduced to expand their regenerative, angiogenic, and antibacterial properties. In the present study, a new formula of bborosilicate bioactive glass nanofibers was prepared and tested for its wound-healing efficacy in a rabbit animal model. The glass formula ((1–2) mol% of B2O3 (68–69) mol% of SiO2, and (29–30) mol% of CaO) was prepared primarily by t… Show more

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Cited by 5 publications
(3 citation statements)
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“…This composite possesses bioactivity gained from the ionic dissolution of bioactive glass on the surface of the scaffold and sufficient strength thanks to the polymer scaffold[ 44 ]. The same was observed in the soft tissue application where researchers reported the disappearance of bioactive glass from the wound surface at day one postoperatively[ 27 , 28 ]. One of the main advantages of bioceramics is the antibacterial effect at the site of application.…”
Section: Capturing the Overall Imagesupporting
confidence: 64%
See 1 more Smart Citation
“…This composite possesses bioactivity gained from the ionic dissolution of bioactive glass on the surface of the scaffold and sufficient strength thanks to the polymer scaffold[ 44 ]. The same was observed in the soft tissue application where researchers reported the disappearance of bioactive glass from the wound surface at day one postoperatively[ 27 , 28 ]. One of the main advantages of bioceramics is the antibacterial effect at the site of application.…”
Section: Capturing the Overall Imagesupporting
confidence: 64%
“…An example of this was a mixture of different types of bioactive glass prepared in an ointment form[ 26 ]. Another form was borosilicate bioactive glass nanofibers, which were applied in full-thickness skin defects in rabbit animal models, where the very early ion release since the first day enhanced the cascade toward cutaneous regeneration[ 27 ]. The results were in agreement with those of an earlier study conducted on dogs[ 28 ] where 13–93Borate-based bioglass promoted full-thickness wound healing.…”
Section: Bioceramics In Soft Tissue Regenerationmentioning
confidence: 99%
“…The ability of bioactive glass nanoparticles to induce the growth of new tissue makes them ideal for wound healing [ 46 , 47 ]. In a previous work [ 48 ], we prepared novel SBGs by the sol–gel method, fabricated and characterized, revealing prominent potential in biomedical applications.…”
Section: Introductionmentioning
confidence: 99%