Nanoscale chemical analysis of 2D molecular materials using tip-enhanced Raman spectroscopy

Mrđenović, Dušan; Cai, Zhiyong; Pandey, Yashashwa; Bartolomeo, Giovanni Luca; Zenobi, Renato; Kumar, Naresh

doi:10.1039/d2nr05127c

Cited by 18 publications

(11 citation statements)

References 105 publications

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“…It is known that peak positions of TERS signals highly depend on the polarization of the electromagnetic field, and hence on the orientation of the polarizing molecules (organic/inorganic fragments) with respect to the excitation field. [ 21 ] Thus, the TERS maps have been generated by integrating the area under the curve, rather than relying on the peak intensity (see Figure S2, Supporting Information). The enhancement factor of the TERS‐STM tip on a malachite green standard sample is ≈6.47 × 10 6 (Supporting Information Enhancement Factor Estimation).…”

Section: Resultsmentioning

confidence: 99%

Capturing Nano‐Scale Inhomogeneity of the Electrode Electrolyte Interface in Sodium‐Ion Batteries Through Tip‐Enhanced Raman Spectroscopy

Dinda,

Trivedi,

Roy

et al. 2023

Advanced Energy Materials

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A prime challenge in the development of new battery chemistries is the fundamental understanding of the generation of the electrode–electrolyte interface (EEI) and its evolution upon cycling. Tip‐enhanced Raman spectroscopy (TERS) under an inert gas atmosphere is employed to study the chemical components of the anode/cathode electrolyte interface in a sodium‐ion battery. After the first cycle, TERS reveals that the EEI mostly consists of organic carbonate/dicarbonate, oligoethylene oxides, α,β‐unsaturated vinyl ketones/acetates, and inorganic species ClO4−, ClO3−, and Na2CO3. Whereas after 5× cycling, the EEI composition has evolved to contain long chain monodentate or bridging/bidentate carboxylates and alkoxides. The TERS map reveals the nano‐scale heterogeneity present in the EEI layers and elucidates a multilayered nano‐mosaic coating structure. The sheer volume of Raman signature present in the TERS signal can completely unravel the mysteries regarding the chemical composition and may shed light to the physicochemical behavior of the EEI.

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Section: Resultsmentioning

confidence: 99%

Capturing Nano‐Scale Inhomogeneity of the Electrode Electrolyte Interface in Sodium‐Ion Batteries Through Tip‐Enhanced Raman Spectroscopy

Dinda,

Trivedi,

Roy

et al. 2023

Advanced Energy Materials

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“…More recently, Mrđenović et al. (2023) showed the capability of TERS to detect biomolecules under ambient conditions at a sub‐nanometer spatial resolution.…”

Section: Methodsmentioning

confidence: 99%

Applications of Raman spectroscopy in clinical medicine

Qi,

Chen,

et al. 2024

Food Frontiers

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Raman spectroscopy is a nondestructive and highly effective technique for analyzing biological tissues and diagnosing diseases by providing detailed spectral information about the specific molecular structures of substances. Its efficacy in these applications has been widely recognized, making it a powerful tool in the field. This article presents a comprehensive overview of the latest developments in Raman spectroscopy and its wide‐ranging applications in the diagnosis of critical diseases, such as cancer, infections, neurodegenerative diseases, and predicting surgical outcomes. It highlights the significant contributions of Raman spectroscopy in these areas, shedding light on its potential as a valuable diagnostic tool. This article delves into the advancements of Raman spectroscopy in biomedical sciences, with a specific focus on state‐of‐the‐art techniques such as surface‐enhanced Raman spectroscopy, resonance Raman spectroscopy, and tip‐enhanced Raman spectroscopy. These techniques have shown great potential in various applications within the field. The article explores their use in ex vivo and in vivo medical diagnosis, covering topics such as sample collection, data processing, and the successful establishment of correlations between Raman spectra and biochemical information in specific diseases. Furthermore, the article discusses the limitations of the current research and offers insights into potential future directions for further exploration in the field of Raman spectroscopy in biomedical sciences.

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“…Conversely, atom probe tomography can also furnish nanoscale information but is destructive and necessitates time-consuming sample preparation. 14 Over the past two decades, tip-enhanced Raman spectroscopy (TERS) has emerged as a promising analytical tool 15,16 for nanoscale molecular characterization across various materials and processes such as two-dimensional (2D) materials, 17−19 catalysts, 20,21 polymers, 22,23 biomaterials, 24−26 organic photovoltaic devices, 27 self-assembled monolayers, 28,29 surface chemical reactions, etc. 30 TERS employs a metallic scanning probe microscopy tip positioned at the focal point of an excitation laser, which generates an enhanced and confined electromagnetic field (also called near-field) at the tip apex through a combination of the localized surface plasmon resonance and lightning rod effect.…”

Section: ■ Introductionmentioning

confidence: 99%

Nanoscale Chemical Analysis of Thin Film Solar Cell Interfaces Using Tip-Enhanced Raman Spectroscopy

Bienz,

Spaggiari,

Calestani

et al. 2024

ACS Appl. Mater. Interfaces

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Interfacial regions play a key role in determining the overall power conversion efficiency of thin film solar cells. However, the nanoscale investigation of thin film interfaces using conventional analytical tools is challenging due to a lack of required sensitivity and spatial resolution. Here, we surmount these obstacles using tip-enhanced Raman spectroscopy (TERS) and apply it to investigate the absorber (Sb 2 Se 3 ) and buffer (CdS) layers interface in a Sb 2 Se 3 -based thin film solar cell. Hyperspectral TERS imaging with 10 nm spatial resolution reveals that the investigated interface between the absorber and buffer layers is far from uniform, as TERS analysis detects an intermixing of chemical compounds instead of a sharp demarcation between the CdS and Sb 2 Se 3 layers. Intriguingly, this interface, comprising both Sb 2 Se 3 and CdS compounds, exhibits an unexpectedly large thickness of 295 ± 70 nm attributable to the roughness of the Sb 2 Se 3 layer. Furthermore, TERS measurements provide compelling evidence of CdS penetration into the Sb 2 Se 3 layer, likely resulting from unwanted reactions on the absorber surface during chemical bath deposition. Notably, the coexistence of ZnO, which serves as the uppermost conducting layer, and CdS within the Sb 2 Se 3 -rich region has been experimentally confirmed for the first time. This study underscores TERS as a promising nanoscale technique to investigate thin film inorganic solar cell interfaces, offering novel insights into intricate interface structures and compound intermixing.

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Nanoscale chemical analysis of 2D molecular materials using tip-enhanced Raman spectroscopy

Abstract: Tip-enhanced Raman spectroscopy (TERS) has emerged as a powerful tool for correlative topographical and chemical imaging at the nanoscale. Herein, we examine the recent progress in the application of TERS to study two-dimensional molecular materials.

Cited by 18 publications

References 105 publications

Capturing Nano‐Scale Inhomogeneity of the Electrode Electrolyte Interface in Sodium‐Ion Batteries Through Tip‐Enhanced Raman Spectroscopy

Capturing Nano‐Scale Inhomogeneity of the Electrode Electrolyte Interface in Sodium‐Ion Batteries Through Tip‐Enhanced Raman Spectroscopy

Applications of Raman spectroscopy in clinical medicine

Nanoscale Chemical Analysis of Thin Film Solar Cell Interfaces Using Tip-Enhanced Raman Spectroscopy

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