Nanoscale Imaging and Characterisation of Amyloid-β

Abstract

I am blessed to have made so many friends throughout this PhD; both within the university and elsewhere. Jenny Mayes and Alex Robson, thank you for brightening my morning with many a cup of coffee and chatter, in addition to all your support with my research. Riccardo Mazzocco, who will always be "my favourite Italian". Kylie O'Shea and Ben Shreeve, without whom I would not have enjoyed nearly as much cake as I have currently. The wonderful Taylor Lura, Emily Smith and Christie Herd, who have made me laugh so hard I have cried. My "Bookend" Louise Walker for fostering my madness and creating the candyfloss world with me. I would like to thank Dr. Christine Shirras for her guidance and support as my teaching mentor. Lastly, my friends in Canada; Ronnie and Liz Drolle, who I would never have had the joy of meeting if it were not for this PhD. All of these people, and more, have made this experience the happiest of my life. You've brought so much joy, sparkle and laughter as we've journeyed together. I'm so lucky to have you in my life. My family's support and belief in me has been paramount throughout my studies, and I thank them from the bottom of my heart of believing in me, comforting me and giving me the strength I have. Most importantly I want to thank my long-suffering husband, Richard. Without you I would not be me, and this would not have happened. We share this achievement as we do everything. I love you now, forever and always and cannot thank you enough for your support and love. IV Dedications The work in this thesis is dedicated to those that sadly did not get the opportunity to see me finish this journey, but offered their unconditional support and love throughout my life. Vera Pennington, who sadly lost her own battle with Alzheimer's disease inspired with her tireless work as a daughter, mother and grandmother. Rex Pennington, who went long before this journey began. Thank you for the memories. Marjorie and Ernest Tinker, without whom I would not have been able to begin this journey. I love and miss you both so much and am eternally grateful for all that you did for me. It breaks my heart you will not see me graduate. V