Nanoscale Materials for Self-Cleaning and Antibacterial Applications

Mokammel, Mohammad A.; Islam, Mohammad J.; Hasanuzzaman, M.; Hashmi, Saleem

doi:10.1016/b978-0-12-803581-8.11585-1

Cited by 15 publications

(8 citation statements)

References 16 publications

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“…Gold nanoparticles (AuNPs) and zinc oxide nanoparticles (ZnONPs) have been shown to be highly stable, biocompatible, non-toxic to humans, and function as an excellent drug delivery system [27,28]. Moreover, the United States Food and Drug Administration has approved ZnONPs as a safe material [29]. As a result, the current work intended to synthesize gold (AuNPs) and zinc oxide (ZnONPs) nanoparticles using phloroglucinol (PG).…”

Section: Introductionmentioning

confidence: 99%

Phloroglucinol-Gold and -Zinc Oxide Nanoparticles: Antibiofilm and Antivirulence Activities towards Pseudomonas aeruginosa PAO1

Khan

Kang

et al. 2021

Marine Drugs

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With the advancement of nanotechnology, several nanoparticles have been synthesized as antimicrobial agents by utilizing biologically derived materials. In most cases, the materials used for the synthesis of nanoparticles from natural sources are extracts. Natural extracts contain a wide range of bioactive components, making it difficult to pinpoint the exact component responsible for nanoparticle synthesis. Furthermore, the bioactive component present in the extract changes according to numerous environmental factors. As a result, the current work intended to synthesize gold (AuNPs) and zinc oxide (ZnONPs) nanoparticles using pure phloroglucinol (PG). The synthesized PG-AuNPs and PG-ZnONPs were characterized using a UV–Vis absorption spectrophotometer, FTIR, DLS, FE-TEM, zeta potential, EDS, and energy-dispersive X-ray diffraction. The characterized PG-AuNPs and PG-ZnONPs have been employed to combat the pathogenesis of Pseudomonas aeruginosa. P. aeruginosa is recognized as one of the most prevalent pathogens responsible for the common cause of nosocomial infection in humans. Antimicrobial resistance in P. aeruginosa has been linked to the development of recalcitrant phenotypic characteristics, such as biofilm, which has been identified as one of the major obstacles to antimicrobial therapy. Furthermore, P. aeruginosa generates various virulence factors that are a major cause of chronic infection. These PG-AuNPs and PG-ZnONPs significantly inhibit early stage biofilm and eradicate mature biofilm. Furthermore, these NPs reduce P. aeruginosa virulence factors such as pyoverdine, pyocyanin, protease, rhamnolipid, and hemolytic capabilities. In addition, these NPs significantly reduce P. aeruginosa swarming, swimming, and twitching motility. PG-AuNPs and PG-ZnONPs can be used as control agents for infections caused by the biofilm-forming human pathogenic bacterium P. aeruginosa.

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Section: Introductionmentioning

confidence: 99%

Phloroglucinol-Gold and -Zinc Oxide Nanoparticles: Antibiofilm and Antivirulence Activities towards Pseudomonas aeruginosa PAO1

Khan

Kang

et al. 2021

Marine Drugs

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“…Gold nanoparticles (AuNP) have received a growing attention due to their brilliant optical properties and wide applications. Under the umbrella of nanomedicine, AuNP have been explored and used for chemical sensing, biomedical diagnosis, drug delivery and targeting, and many other pharmaceutical and biomedical applications [9][10][11][12]. This is due to the unique physicochemical, electrical and optical properties of AuNP including their extraordinary capability to absorb/scatter light in the visible-near infra-red (Vis-NIR) region of the spectrum with very large optical extinction coefficients [2,13,14].…”

Section: Introductionmentioning

confidence: 99%

The Golden Liposomes: Preparation and Biomedical Applications of Gold-Liposome Nanocomposites

Idoudi

Ismail

Rachid

et al. 2023

JNT

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Gold nanoparticles (AuNP) have received a growing attention due to their fascinating physiochemical properties and promising range of biomedical applications including sensing, diagnosis and cancer photothermal ablation. AuNP enjoy brilliant optical properties and ability to convert light into local heat and function as a “nanoheaters” to fight cancer. However, AuNP are poor drug delivery systems as they do not have reservoirs or matrices to achieve an acceptable drug loading efficiency. On the other end, liposome-based nanocarriers do not exhibit such optical properties but are excellent platform for drug loading and they have been proven clinically with a true presence in the market since the FDA approved Doxil® in 1995. Combining the brilliant optical and photothermal properties of AuNP with the excellent drug loading capability of liposome should yield nanocomposites that enjoy the features of both modalities and enable the development of novel and smart drug delivery systems. Therefore, this review discusses the up-to date research on the AuNP-liposome nanocomposites and the current available approaches and protocols for their preparation and characterization. Finally, the biomedical applications of AuNP-liposome nanocomposites and proposed future directions in this field are discussed.

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“…Silver, copper, titanium, zinc, gold, and magnesium are the most commonly used elements involved in NP synthesis; among all, gold nanoparticles (AuNPs) are used widely in biomedical applications due to their good optical properties [6]. According to previous studies, small-sized AuNPs significantly assist in antibacterial activity [7,8]. Plant-mediated route of NP synthesis is less toxic for humans and is environmentally friendly [9,10].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Potential of Gold Nanoparticles Synthesized From Leaf Extract of Syzygium cumini Against Multidrug-Resistant Urinary Tract Pathogens

Diksha¹,

Gupta²,

Gupta³

et al. 2023

Cureus

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Background: Urinary tract infection (UTI) is one of the most commonly encountered bacterial infections. Due to the misuse or excessive use of antibiotics, the upsurge of multidrug-resistance cases in UTIs has now become a global threat to public health. Exploring a newer or safer treatment using green synthesized nanoparticles (NPs) is another substitute for eliminating multidrug-resistant pathogens.Methodology: Leaf extract of Syzygium cumini was used for green synthesis of gold NPs. Synthesis of Syzygium cumini gold nanoparticles (ScAu-NPs) was achieved by optimizing various reaction parameters. These ScAu-NPs were characterized through UV-visible spectroscopy, transmission electron microscope, Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction. ScAu-NPs were then processed for antibacterial activity against clinically isolated multidrug-resistant pathogens like Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Acinetobacter baumannii, Staphylococcus aureus, and Enterococcus faecalis.Results: Characterization of NPs revealed that biosynthesized NPs were spherical in shape. FTIR spectroscopy showed the presence of phenolics and aromatic compounds. Biosynthesized NPs exhibit good antibacterial activity with a significant bacterial reduction seen against all bacterial isolates compared to the controls. Conclusion:From the results of the present study, the formulation of biosynthesized ScAu-NPs can be utilized in drug development for eliminating infections caused by multidrug-resistant pathogens.

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Nanoscale Materials for Self-Cleaning and Antibacterial Applications

Cited by 15 publications

References 16 publications

Phloroglucinol-Gold and -Zinc Oxide Nanoparticles: Antibiofilm and Antivirulence Activities towards Pseudomonas aeruginosa PAO1

Phloroglucinol-Gold and -Zinc Oxide Nanoparticles: Antibiofilm and Antivirulence Activities towards Pseudomonas aeruginosa PAO1

The Golden Liposomes: Preparation and Biomedical Applications of Gold-Liposome Nanocomposites

Antibacterial Potential of Gold Nanoparticles Synthesized From Leaf Extract of Syzygium cumini Against Multidrug-Resistant Urinary Tract Pathogens

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