Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy

Ni, Kaiyuan; Lan, Guangxu; Veroneau, Samuel S.; Duan, Xiaopin; Song, Yang; Lin, Wenbin

doi:10.1038/s41467-018-06655-7

Cited by 282 publications

(205 citation statements)

References 54 publications

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“…In the last few decades, metal–organic framework (MOF) nanomaterials have witnessed the development of nanotheranostic platforms. [ 26–30 ] For the high porosity and large surface area, many biocompatible MOF nanomaterials (e.g., MIL‐100, MIL‐101, ZIF‐8, etc.) have been used to carry small‐molecule theranostic agents.…”

Section: Methodsmentioning

confidence: 99%

Tumor‐Microenvironment‐Triggered Ion Exchange of a Metal–Organic Framework Hybrid for Multimodal Imaging and Synergistic Therapy of Tumors

et al. 2020

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Nanotheranostic agents (NTAs) that integrate diagnostic capabilities and therapeutic functions have great potential for personalized medicine, yet poor tumor specificity severely restricts further clinical applications of NTAs. Here, a pro‐NTA (precursor of nanotheranostic agent) activation strategy is reported for in situ NTA synthesis at tumor tissues to enhance the specificity of tumor therapy. This pro‐NTA, also called PBAM, is composed of an MIL‐100 (Fe)‐coated Prussian blue (PB) analogue (K2Mn[Fe(CN)6]) with negligible absorption in the near‐infrared region and spatial confinement of Mn2+ ions. In a mildly acidic tumor microenvironment (TME), PBAM can be specifically activated to synthesize the photothermal agent PB nanoparticles, with release of free Mn2+ ions due to the internal fast ion exchange, resulting in the “ON” state of both T1‐weighted magnetic resonance imaging and photoacoustic signals. In addition, the combined Mn2+‐mediated chemodynamic therapy in the TME and PB‐mediated photothermal therapy guarantee a more efficient therapeutic performance compared to monotherapy. In vivo data further show that the pro‐NTA activation strategy could selectively brighten solid tumors and detect invisible lymph node metastases with high specificity.

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Section: Methodsmentioning

confidence: 99%

Tumor‐Microenvironment‐Triggered Ion Exchange of a Metal–Organic Framework Hybrid for Multimodal Imaging and Synergistic Therapy of Tumors

et al. 2020

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“…[232] The two most important forms of phototherapy for cancer treatment are photothermal therapy (PTT) and photodynamic therapy (PDT). [232] The two most important forms of phototherapy for cancer treatment are photothermal therapy (PTT) and photodynamic therapy (PDT).…”

Section: Combination Of Immunotherapy and Traditional Managementsmentioning

confidence: 99%

Immunomodulatory Nanosystems

et al. 2019

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Immunotherapy has emerged as an effective strategy for the prevention and treatment of a variety of diseases, including cancer, infectious diseases, inflammatory diseases, and autoimmune diseases. Immunomodulatory nanosystems can readily improve the therapeutic effects and simultaneously overcome many obstacles facing the treatment method, such as inadequate immune stimulation, off‐target side effects, and bioactivity loss of immune agents during circulation. In recent years, researchers have continuously developed nanomaterials with new structures, properties, and functions. This Review provides the most recent advances of nanotechnology for immunostimulation and immunosuppression. In cancer immunotherapy, nanosystems play an essential role in immune cell activation and tumor microenvironment modulation, as well as combination with other antitumor approaches. In infectious diseases, many encouraging outcomes from using nanomaterial vaccines against viral and bacterial infections have been reported. In addition, nanoparticles also potentiate the effects of immunosuppressive immune cells for the treatment of inflammatory and autoimmune diseases. Finally, the challenges and prospects of applying nanotechnology to modulate immunotherapy are discussed.

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“…Mitochondria, the energy house of cell, is vital in the growth and metastasis of tumor cells. 34,35 Thus, we were concerned with the question whether miR-31 contributed to mitochondrial dysfunction in HepG2 cells. To get a certain answer, we also investigated the role of miR-31 in mitochondrial metabolism in the present study.…”

Section: Mir-31 Contributes To Mitochondrial Dysfunction In Hepg2 Cellsmentioning

confidence: 99%

<p>miR-31 Modulates Liver Cancer HepG2 Cell Apoptosis and Invasion via ROCK1/F-Actin Pathways</p>

Zhang¹,

Xu²,

Yang³

2020

OTT

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Purpose: Liver cancer is one of the most common malignant tumor in the world. miR-31 is downregulated in liver cancer and associated with tumor growth and metastasis. However, the underlying mechanism remains unclear. Methods: Cellular apoptosis was detected via MTT, TUNEL assay, LDH release and Annexin V/PI flow-cytometry analysis. Cellular migration and invasion were measured by the Transwell chamber assay. Mitochondrial functions were evaluated via mitochondrial membrane potential JC-1 staining and mPTP opening assessment. The mitophagy activity was examined via Western blots. Results: In the present study, our results confirm that miR-31 promotes apoptosis and inhibits proliferation and metastasis in liver cancer HepG2 cells. In vitro, miR-31 promotes HepG2 cell apoptosis through the mitochondrial pathway as indicated by mitochondrial potential reduction, increased mPTP opening time, cty-c release and imbalance of pro-and anti-apoptotic proteins. Furthermore, miR-31 reduces the energy generation by inhibiting mitochondrial respiratory function. At last, it is demonstrated that miR-31 triggers the mitochondrial damage via ROCK1/F-actin pathway. Inhibiting the ROCK1/F-actin pathway abolishes the effects of miR-31 mimic on mitochondrial injury, apoptosis, proliferation arrest and migration inhibition. Conclusion: Our results reveal that miR-31 can inhibit HepG2 cell survival and metastasis by activating the ROCK1/F-actin pathway.

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Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy

Cited by 282 publications

References 54 publications

Tumor‐Microenvironment‐Triggered Ion Exchange of a Metal–Organic Framework Hybrid for Multimodal Imaging and Synergistic Therapy of Tumors

Tumor‐Microenvironment‐Triggered Ion Exchange of a Metal–Organic Framework Hybrid for Multimodal Imaging and Synergistic Therapy of Tumors

Immunomodulatory Nanosystems

<p>miR-31 Modulates Liver Cancer HepG2 Cell Apoptosis and Invasion via ROCK1/F-Actin Pathways</p>

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