Nanoscale MOFs in nanomedicine applications: from drug delivery to therapeutic agents

Abstract

Metal-organic frameworks (MOFs) hold great promise to shed light on the widespread applications of biomedicine, nanomedicine, etc. Benefiting from the high porosity and facile modification of MOFs, which have been...

Copper(ii)-MOFs for bio-applications

“…Also, the chemical functionalization of MOFs has been exploited for effective drug delivery. 81,82 In MOF-based drug delivery systems the interaction between the host and the guest is dictated by p-p interactions, coordination bonds, and van der Waals forces, including hydrogen bonds. In addition, in some cases there is a strong electrostatic interaction between ionic drugs and charged pores or frameworks.…”

Platinum nanoparticle-anchored metal–organic complex nanospheres by a coordination–crystallization approach for enhanced sonodynamic therapy of tumors

“…[1][2][3] The mechanism of SDT relies on the generation of a cavitation effect or highly cytotoxic reactive oxygen species (ROS) through ultrasound (US) irradiation upon sonosensitizers. [4][5][6][7] Recently, different sonosensitizers have been developed to enhance the therapeutic efficacy of SDT via mediating the generation efficiency of ROS. [8][9][10][11] Metal-organic complexes (MOCs) formed by the coordination of metal-ions or clusters with organic ligands have significant potential for SDT applications due to their unique sound responsiveness and rapid diffusion of ROS.…”

Empowering the Water Oxidation Activity of the Bimetallic Metal–Organic Framework by Annexing Gold Nanoparticles over the Catalytic Surface

“…14−17 Because of their unique properties, they are employed in numerous applications like gas separation, 18,19 gas storage, 20,21 sensing, 22,23 catalysis, 24,25 and drug administration. 26,27 Moreover, the MOF is used in various fields showing excellent performance in electrochemical applications such as energy conversion, 28,29 energy storage, 30,31 and electrocatalysis. 32,33 However, there are still many MOFbased materials that do not perform well as electrocatalysts because of their poor conductivity and chemical stability in alkaline and acidic electrolytes.…”