Nanoscale porous organic polymers for drug delivery and advanced cancer theranostics

Abstract

This tutorial review highlights the potential of nanoscale porous organic polymers in diagnosis and therapy of different types of cancers.

LAPONITE® nanodisk-based platforms for cancer diagnosis and therapy

“…[10][11][12][13][14][15][16] For nanomedicine development, it is inevitable to choose a suitable nanomaterial as a platform. Various nanomaterials including organic nanomaterials such as liposomes, micelles, dendrimers, polymers, etc., [17][18][19][20][21][22] and inorganic nanomaterials such as ultrasmall iron oxide (Fe 3 O 4 ), gold, silica (SiO 2 ), layered double hydroxide (LDH), laponite ® (LAP) nanoparticles (NPs), etc. 5,[23][24][25] have been extensively explored.…”

Ambient synthesis of an iminium-linked covalent organic framework for synergetic RNA interference and metabolic therapy of fibrosarcoma

“…Furthermore, the counterions in cationic COFs could be replaced with negatively charged metabolic inhibitors and chemotherapeutic drugs via ion exchange. 39 Thus, multifunctional COF-based siRNA delivery and metabolic therapy could be logically achieved.…”

Self-Assembly of Small Organic Molecules into Luminophores for Cancer Theranostic Applications

“…With the development of these advanced technologies, multimodal systems combining imaging and drug therapy have become the focus of interest due to their theranostic functions [ 13 , 14 ]. However, the design of theranostic probes generally involves the modification of nanomaterials or conjugation of fluorescent probes to bioactive drugs, which involves a complicated system, and it is hard to effectively control their cellular and in vivo behaviors [ 15 ].…”