Nanoscale Porphyrin Metal-Organic Frameworks Deliver siRNA for Alleviating Early Pulmonary Fibrosis in Acute Lung Injury

Weng, Changmei; Li, Guanhua; Dongdong, ZHANG; Duan, Zhaoxia; Chen, Kuijun; Li, Tao; Wang, Jianmin

doi:10.3389/fbioe.2022.939312

Cited by 9 publications

(4 citation statements)

References 52 publications

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“… 637 Additionally, ALI can develop into acute respiratory distress syndrome in more serious injuries, which lacks novel and efficient therapies. 638 , 639 Inflammation and oxidative stresses are essential for the progression of ALI. 640 However, the molecular mechanisms of sepsis-induced lung inflammatory injury are yet to be determined.…”

Section: Introductionmentioning

confidence: 99%

The sirtuin family in health and disease

Zhang

Chen

et al. 2022

Sig Transduct Target Ther

292

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Sirtuins (SIRTs) are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in numerous biological processes. Currently, seven mammalian homologs of yeast Sir2 named SIRT1 to SIRT7 have been identified. Increasing evidence has suggested the vital roles of seven members of the SIRT family in health and disease conditions. Notably, this protein family plays a variety of important roles in cellular biology such as inflammation, metabolism, oxidative stress, and apoptosis, etc., thus, it is considered a potential therapeutic target for different kinds of pathologies including cancer, cardiovascular disease, respiratory disease, and other conditions. Moreover, identification of SIRT modulators and exploring the functions of these different modulators have prompted increased efforts to discover new small molecules, which can modify SIRT activity. Furthermore, several randomized controlled trials have indicated that different interventions might affect the expression of SIRT protein in human samples, and supplementation of SIRT modulators might have diverse impact on physiological function in different participants. In this review, we introduce the history and structure of the SIRT protein family, discuss the molecular mechanisms and biological functions of seven members of the SIRT protein family, elaborate on the regulatory roles of SIRTs in human disease, summarize SIRT inhibitors and activators, and review related clinical studies.

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Section: Introductionmentioning

confidence: 99%

The sirtuin family in health and disease

Zhang

Chen

et al. 2022

Sig Transduct Target Ther

292

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“…Ultimately, ZPM@PDE nanoparticles effectively delivered siZEB1/2, significantly inhibited ZEB1/2 expression, and alleviated early pulmonary fibrosis in LPS-treated mice ( Figure 4 and Table 1 ). 34 …”

Section: Application Of Nanoparticles In the Treatment Of Alimentioning

confidence: 99%

Novel application of nanomedicine for the treatment of acute lung injury: a literature review

Chen,

Tang

2024

Ther Adv Respir Dis

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Nanoparticles have attracted extensive attention due to their high degree of cell targeting, biocompatibility, controllable biological activity, and outstanding pharmacokinetics. Changing the size, morphology, and surface chemical groups of nanoparticles can increase the biological distribution of agents to achieve precise tissue targeting and optimize therapeutic effects. Examples of their use include nanoparticles designed for increasing antigen-specific immune responses, developing vaccines, and treating inflammatory diseases. Nanoparticles show the potential to become a new generation of therapeutic agents for regulating inflammation. Recently, many nanomaterials with targeted properties have been developed to treat acute lung injury/acute respiratory distress syndrome (ALI/ARDS). In this review, we provide a brief explanation of the pathological mechanism underlying ALI/ARDS and a systematic overview of the latest technology and research progress in nanomedicine treatments of ALI, including improved nanocarriers, nanozymes, and nanovaccines for the targeted treatment of lung injury. Ultimately, these nanomedicines will be used for the clinical treatment of ALI/ARDS.

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“…In order to find a way to alleviate early pulmonary fibrosis in mice, Weng et al. prepared a nanoparticle ZPM@PDE‐siZEB1/2, [88] which delivered siZEB1 and siZEB2 into the lungs of ALI mice through trachea administration. Compared with the lung tissues of mice in the control group and LPS group, the symptoms of LPS+ZPM@PDE‐siZEB1/2 group were significantly relieved, the expression levels of ZEB1 and ZEB2 are significantly decreased.…”

Section: Applications Of Nucleic Acid‐functional Mofsmentioning

confidence: 99%

Metal‐Organic Frameworks Nanocarriers for Functional Nucleic Acid Delivery in Biomedical Applications

Shang

Chen

et al. 2023

The Chemical Record

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Metal−organic frameworks (MOFs), a distinctive funtionalmaterials which is constructed by various metal ions and organic molecules, have gradually attracted researchers′ attention from they were founded. In the last decade, MOFs emerge as a biomedical material with potential applications due to their unique properties. However, the MOFs performed as nanocarriers for functional nucleic acid delivery in biomedical applications rarely summarized. In this review, we introduce recent developments of MOFs for nucleic acid delivery in various biologically relevant applications, with special emphasis on cancer therapy (including siRNA, ASO, DNAzyme, miRNA and CpG oligodeoxynucleotides), bioimaging, biosensors and separation of biomolecules. We expect the accomplishment of this review could benefit certain researchers in biomedical field to develop novel sophisticated nanocarriers for functional nucleic acid delivery based on the promising material of MOFs.

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Nanoscale Porphyrin Metal-Organic Frameworks Deliver siRNA for Alleviating Early Pulmonary Fibrosis in Acute Lung Injury

Cited by 9 publications

References 52 publications

The sirtuin family in health and disease

The sirtuin family in health and disease

Novel application of nanomedicine for the treatment of acute lung injury: a literature review

Metal‐Organic Frameworks Nanocarriers for Functional Nucleic Acid Delivery in Biomedical Applications

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