Nanoscale strides: exploring innovative therapies for breast cancer treatment

Mugundhan, Sruthi Laakshmi; Mohan, Mothilal

doi:10.1039/d4ra02639j

RSC Adv.

2024

DOI: 10.1039/d4ra02639j

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Nanoscale strides: exploring innovative therapies for breast cancer treatment

Sruthi Laakshmi Mugundhan,

Mothilal Mohan

Abstract: Nanotechnology revolutionizes breast cancer treatment by improving drug delivery, overcoming barriers, and reducing side effects. This review highlights its potential and superiority over conventional methods, transforming breast cancer management.

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Cited by 8 publications

References 183 publications

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A New Hetero‐Bimetallic [Fe(III)‐Mn(I)] Complex as a Dual Modality, Theranostic Tool for Photoactivated Anticancer Therapy

Panwar,

Upadhyay,

Mukherjee

et al. 2024

Applied Organom Chemis

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We developed a novel hetero‐bimetallic Fe(III)‐Mn(I) complex by combining hydroxyl radicals generating Fe(III)‐Phenolato/Carboxylato and CO‐releasing Mn(I)(CO)3 complexes to achieve a dual‐modality theranostic tool for photoactivated anticancer therapy. Fe(III)‐Phenolato/Carboxylato and Mn(I)(CO)3 complexes were conjugated through the amide coupling to synthesize the bimetallic Fe(III)‐Mn(I) complex ([Fe‐Mn]) and characterized analytically and spectroscopically. Various photophysical assays have confirmed the production of hydroxyl radicals and the release of CO when the biologically benign [Fe‐Mn] complex is activated by visible light (400–700 nm), resulting in a significant increase in luminescence intensity. The cytotoxic potential of the complex, [Fe‐Mn] resulted from the photoactivated enrichment of ROS and CO in the A549 cells with the photoindex of ~35 leaving HPL1D cells unaffected. We probed the caspase 3/7‐dependent apoptosis and the theranostic potential of the complex, [Fe‐Mn] on photoactivation in vitro. The hetero‐bimetallic Fe(III)‐Mn(I) complex ([Fe‐Mn]) provides an ideal example of a dual‐modality next‐generation theranostic tool for photoactivated anticancer therapy.

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A New Hetero‐Bimetallic [Fe(III)‐Mn(I)] Complex as a Dual Modality, Theranostic Tool for Photoactivated Anticancer Therapy

Panwar,

Upadhyay,

Mukherjee

et al. 2024

Applied Organom Chemis

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Nanomedicine for cancer patient‐centered care

Sorrentino,

Ciummo,

Fieni

et al. 2024

MedComm

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Cancer is a leading cause of morbidity and mortality worldwide, and an increase in incidence is estimated in the next future, due to population aging, which requires the development of highly tolerable and low‐toxicity cancer treatment strategies. The use of nanotechnology to tailor treatments according to the genetic and immunophenotypic characteristics of a patient's tumor, and to allow its targeted release, can meet this need, improving the efficacy of treatment and minimizing side effects. Nanomedicine‐based approach for the diagnosis and treatment of cancer is a rapidly evolving field. Several nanoformulations are currently in clinical trials, and some have been approved and marketed. However, their large‐scale production and use are still hindered by an in‐depth debate involving ethics, intellectual property, safety and health concerns, technical issues, and costs. Here, we survey the key approaches, with specific reference to organ‐on chip technology, and cutting‐edge tools, such as CRISPR/Cas9 genome editing, through which nanosystems can meet the needs for personalized diagnostics and therapy in cancer patients. An update is provided on the nanopharmaceuticals approved and marketed for cancer therapy and those currently undergoing clinical trials. Finally, we discuss the emerging avenues in the field and the challenges to be overcome for the transfer of nano‐based precision oncology into clinical daily life.

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Navigating the therapeutic landscape for breast cancer: targeting breast cancer stem cells

Dey,

Dinakar,

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Nanoscale strides: exploring innovative therapies for breast cancer treatment

Abstract: Nanotechnology revolutionizes breast cancer treatment by improving drug delivery, overcoming barriers, and reducing side effects. This review highlights its potential and superiority over conventional methods, transforming breast cancer management.

Cited by 8 publications

References 183 publications

A New Hetero‐Bimetallic [Fe(III)‐Mn(I)] Complex as a Dual Modality, Theranostic Tool for Photoactivated Anticancer Therapy

A New Hetero‐Bimetallic [Fe(III)‐Mn(I)] Complex as a Dual Modality, Theranostic Tool for Photoactivated Anticancer Therapy

Nanomedicine for cancer patient‐centered care

Navigating the therapeutic landscape for breast cancer: targeting breast cancer stem cells

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