Nanoscale surface characterization of biphasic calcium phosphate, with comparisons to calcium hydroxyapatite and β-tricalcium phosphate bioceramics

França, Rodrigo; Samani, Taraneh Djavanbakht; Bayade, Ghislaine; Yahia, L’Hocine; Sacher, E.

doi:10.1016/j.jcis.2013.12.055

Cited by 72 publications

(39 citation statements)

References 35 publications

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“…Successful bone defect repair requires the use of porous scaffolds, which should have the features such as high porosity along with macropores and 3D interconnected pore structures, in order to have permeability and diffusion properties for both cell penetration and proper vascularization of the ingrowths tissue [11][12][13]. Bone tissues cannot grow into the interior of scaffold when the pore size is less than 100 mm [12][13][14]. As far, diverse methods have been developed to prepare porous β-TCP materials and a sponge replication [14][15][16], and a direct foaming of ceramic suspensions [17] were the most common methods.…”

Section: Introductionmentioning

confidence: 99%

Development of Mg-containing porous β-tricalcium phosphate scaffolds for bone repair

Šalma-Ancāne

Stipniece

Putniņš

et al. 2015

Ceramics International

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Section: Introductionmentioning

confidence: 99%

Development of Mg-containing porous β-tricalcium phosphate scaffolds for bone repair

Šalma-Ancāne

Stipniece

Putniņš

et al. 2015

Ceramics International

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“…In addition, the macropores (>100 µm) and micropores (<100 µm) of the scaffold promote bone formation by contributing to the diffusion of proteins essential for bone conduction. Furthermore, the micropores that link the pores are able to induce new bone formation into the interior of the pores 22) . Apaceram -AX is characterized by a mean macropore size of 150 µm, and are connected in three dimensions by micropores smaller than 40 µm 23) .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a Porous Hydroxyapatite Granule and Gelatin Hydrogel Microsphere Composite in Bone Regeneration

Yokota

Matsuno

Tabata

et al. 2017

J. Hard Tissue Biology.

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The purpose of this study was to investigate the property of hydroxyapatite (HA)/gelatin hydrogel (GH) composite granules as a scaffold and controlled-release carrier of basic fibroblast growth factor (bFGF) for bone regeneration. HA granules and GH microsphere at various weight ratios to the HA granules were mixed. The composite provided the controlled release of bFGF in vitro. The critical-sized bone defects of 6 mm diameter were created in the skull of New Zealand white rabbits and the composite granules with or without incorporated bFGF, were implanted into the defects. Bone regeneration and were evaluated by computed tomography and H-E staining. The composite granules incorporating bFGF promoted significantly higher bone regeneration at the defect site as compared to the bFGF-free composites. Further, the amount of new bone increased in proportion to the amount of GH microspheres incorporated into the composite. We conclude that the bFGF-impregnated HA/GH composite granules is useful for bone regeneration.

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“…Third, it can be used for small or large devices. Fourth, the speed of performing the testing and the lower cost of the analyses . However, it is important to keep in mind that our two techniques are interdependent: XPS is a quantitative analysis technique that probes the first 4–10 nm of the surface depth, whereas TOF‐SIMS is a qualitative technique that probes only the first few layers of atoms.…”

Section: Discussionmentioning

confidence: 99%

Characterization of endotoxins on orthopaedic fixation screws, using physicochemical surface analyses

França

Alfa

Olson

et al. 2016

Journal Orthopaedic Research

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The objective of this study was to determine if surface analysis techniques could be used to detect endotoxin on stainless steel malleolus screws. New malleolus screws were compared to ones that had been coated in purified lipopolysaccharide (LPS) or Artificial Test Soil (ATS) containing lipopolysaccharide. X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), and time-of flight secondary ion mass spectrometry (TOF-SIMS) were used to assess the fixation screws surface. Organic material was visualized on the LPS and ATS-LPS inoculated screws but not on the new unsoiled screws. This was further supported by the peaks observed at masses between 40 and 100 D in TOF-SIMS spectra of the LPS and ATS-LPS inoculated screws. After deconvolution of N1s high resolution XPS spectra, the LPS inoculated screws showed amide groups whereas the ATS-LPS inoculated screws showed predominantly nitroso groups (C-NO). Our data demonstrate that surface analysis can be used to detect organic residuals present on fixation screws. The XPS data confirmed that LPS reacted predominantly with positively charged surface metallic ions (Fe and Cr), whereas proteins reacted with the surface oxide layer of fixation screws, forming C-NO groups. The application of these surface analysis techniques will be helpful in determining if the reprocessing of such items results in an accumulation of organic material that might lead to aseptic loosening, when implanted. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:240-247, 2017.

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Nanoscale surface characterization of biphasic calcium phosphate, with comparisons to calcium hydroxyapatite and β-tricalcium phosphate bioceramics

Cited by 72 publications

References 35 publications

Development of Mg-containing porous β-tricalcium phosphate scaffolds for bone repair

Development of Mg-containing porous β-tricalcium phosphate scaffolds for bone repair

Evaluation of a Porous Hydroxyapatite Granule and Gelatin Hydrogel Microsphere Composite in Bone Regeneration

Characterization of endotoxins on orthopaedic fixation screws, using physicochemical surface analyses

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