Nanoscaled red blood cells facilitate breast cancer treatment by combining photothermal/photodynamic therapy and chemotherapy

Wan, Guoyun; Chen, Bo-Wei; Li, Ling; Wang, Dan; Shi, Shurui; Zhang, Tao; Wang, Yue; Zhang, Lianyun; Wang, Yinsong

doi:10.1016/j.biomaterials.2017.11.002

Cited by 176 publications

(133 citation statements)

References 35 publications

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“…The fluorescence signal of DOX gradually became stronger as a function of time, which implied that intracellular uptake of PL/ACC‐DOX&ICG was time‐dependent and was positively related to incubation duration. After 4 h of coincubation with PL/ACC‐DOX&ICG ( Figure A), the red DOX fluorescence was mostly localized in the nucleus, while the green ICG fluorescence was mainly localized in the cytoplasm . Since only free DOX molecules could enter the nucleus and they tended to remain in the nucleus rather than in the plasma, it was inferred that PL/ACC‐DOX&ICG could be quickly dissociated, and quite a number of DOX molecules that were entrapped in PL/ACC‐DOX&ICG were released as free molecules after internalization.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, breast cancer therapy that relies on a single chemotherapy agent fails to achieve satisfactory therapeutic efficacy. Therefore, current progress in chemotherapy has gradually turned to combinational therapy, which can integrate the advantages of other treatments, such as photothermal therapy (PTT), gene therapy, and immunotherapy, for a favorable therapeutic outcome …”

Section: Introductionmentioning

confidence: 99%

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Water‐Responsive Hybrid Nanoparticles Codelivering ICG and DOX Effectively Treat Breast Cancer via Hyperthermia‐aided DOX Functionality and Drug Penetration

Liu

Wang

et al. 2019

Adv Healthcare Materials

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Tumor growth and metastasis are the major causes of high mortality in breast cancer. In this study, a water‐responsive phospholipid‐calcium‐carbonate hybrid nanoparticle (PL/ACC‐DOX&ICG) surface modified with a phospholipid shell is designed and covered with a shielding polymer polyethylene glycol; this development is loaded with the photosensitizer indocyanine green (ICG) and the chemotherapeutic drug doxorubicin (DOX) for near‐infrared (NIR) imaging and chemophotothermal combination therapy against breast cancer. PL/ACC‐DOX&ICG exhibits satisfactory stability against various aqueous environments with minimal drug leakage and can readily decompose to facilitate quick drug release into cancer cells. In vivo biodistribution studies, PL/ACC‐DOX&ICG demonstrated strong tumor‐homing properties. Interestingly, the in vitro cellular uptake and intratumoral penetration depth of PL/ACC‐DOX&ICG are significantly enhanced under NIR laser irradiation, owing to ICG‐induced hyperthermia, which not only enhances cell permeability and fluidity but also disrupts the dense tumor extracellular matrix. Compared to chemotherapy or photothermal therapy alone, chemophotothermal combination therapy synergistically induces apoptosis and death in 4T1 cells. Moreover, compared with the phosphate buffer saline group, the combined treatment suppress primary tumor growth at a rate of approximately 94.88% and decrease the number of metastatic nodules by about 93.6%. Therefore, PL/ACC‐DOX&ICG may be a promising nanoplatform for breast cancer treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Water‐Responsive Hybrid Nanoparticles Codelivering ICG and DOX Effectively Treat Breast Cancer via Hyperthermia‐aided DOX Functionality and Drug Penetration

Liu

Wang

et al. 2019

Adv Healthcare Materials

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“…Thus, it becomes feasible to load NIR‐activated photosensitizers in Au@Rh‐CM to achieve concurrent PTT and PDT upon single NIR laser irradiation, which can simplify treatment procedures and reduce therapy time. To demonstrate this, the photosensitizer ICG was particularly chosen for its excitability with a deep tissue penetration 808‐nm NIR laser approved for clinical use by the U.S. Food and Drug Administration (FDA), [ 34 ] and ICG was loaded into the mesopores of Au@Rh‐CM nanostructures. As shown in Figure 1g, Au@Rh‐ICG‐CM nanocomposites did exhibit a slight redshift of characteristic ICG absorption peak from 780 to 810 nm in contrast to no noticeable shift of the physically mixed Au@Rh‐CM and free ICG, confirming successful loading of ICG in Au@Rh‐CM nanostructures.…”

Section: Methodsmentioning

confidence: 99%

A Porous Au@Rh Bimetallic Core–Shell Nanostructure as an H₂O₂‐Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy

et al. 2020

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In treatment of hypoxic tumors, oxygen‐dependent photodynamic therapy (PDT) is considerably limited. Herein, a new bimetallic and biphasic Rh‐based core–shell nanosystem (Au@Rh‐ICG‐CM) is developed to address tumor hypoxia while achieving high PDT efficacy. Such porous Au@Rh core–shell nanostructures are expected to exhibit catalase‐like activity to efficiently catalyze oxygen generation from endogenous hydrogen peroxide in tumors. Coating Au@Rh nanostructures with tumor cell membrane (CM) enables tumor targeting via homologous binding. As a result of the large pores of Rh shells and the trapping ability of CM, the photosensitizer indocyanine green (ICG) is successfully loaded and retained in the cavity of Au@Rh‐CM. Au@Rh‐ICG‐CM shows good biocompatibility, high tumor accumulation, and superior fluorescence and photoacoustic imaging properties. Both in vitro and in vivo results demonstrate that Au@Rh‐ICG‐CM is able to effectively convert endogenous hydrogen peroxide into oxygen and then elevate the production of tumor‐toxic singlet oxygen to significantly enhance PDT. As noted, the mild photothermal effect of Au@Rh‐ICG‐CM also improves PDT efficacy. By integrating the superiorities of hypoxia regulation function, tumor accumulation capacity, bimodal imaging, and moderate photothermal effect into a single nanosystem, Au@Rh‐ICG‐CM can readily serve as a promising nanoplatform for enhanced cancer PDT.

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“…Therefore, hemorrhage could be used as a sign of therapeutic failure in cancer patients, because it promotes tumor cell growth and anticancer drug resistance [44]. Facilitation of breast cancer treatment by nanoscaled erythrocytes is via a combination of photodynamic, photothermal, and chemotherapy [45]. Erythrocytes can be lost in the blood lost from cancer surgery and anticancer drugs which affect fast-dividing normal cells and cancerous cells, indicating the drugs cannot differentiate good cells from bad cells [41].…”

Section: Diseases Of Erythrocytesmentioning

confidence: 99%

Effects of Therapeutic and Toxic Agents on Erythrocytes of Different Species of Animals

Saganuwan¹

2019

Erythrocyte

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A preponderance of therapeutic and toxic agents that affect erythrocytes is being used in preclinical and clinical settings. Such agents are responsible for wrong diagnosis of a myriad of diseases and poor prognosis of some therapeutic interventions. In view of this, literature search was carried out with a view to investigate morphometry of erythrocytes in various diseased conditions and species of animals. Findings have shown that erythrocyte size, area, and volume vary in different species of animals under different diseased conditions. Environmental factors, toxicants, toxins, therapeutics, and management system, among others, can cause erythrocyte deformation, leading to anemia. Erythrocyte-related diseases include but not limited to sickle cell anemia, malaria, cancer, psychiatric illness, and chronic inflammation. Hence the principal source of our survival is erythrocyte, because it transports oxygen needed for metabolism of cell nutrients. erythrocytes (4.2-6.2 Â 10 12 /L), hemoglobin (100 g/100 mL), and hematocrit (38-54%) of the total blood volume are the standards for human species [12]. Variation in species, age, environmental factors, management system, and pathological conditions could affect the size, shape, area, and volume of erythrocytes. MethodologyExtensive literature search was carried out to identify differences between normal and abnormal erythrocytes of various species of animals including the ones in the wild. Information on beneficial and toxic effects of drugs, chemical toxicants, toxins, plant extracts, chemicals, and diseased conditions were searched on erythrocyte shape, size, and volume for various species of animals including human. Some developed formulas were modified for determination of anemic, polycythemic, hydrated, and dehydrated erythrocytes. Physiological and pathological features of the erythrocytes were also highlighted. Preclinical and clinical values of the changes in erythrocytes in relation to blood diseases caused by various agents were critically analyzed. Effects of toxic and therapeutic agents on metabolic, cancer, infectious, inheritable, and noninheritable diseases of erythrocytes, such as sickle cell anemia, malaria, and hereditary spherocytosis, among others, were elucidated. Erythrocyte

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Nanoscaled red blood cells facilitate breast cancer treatment by combining photothermal/photodynamic therapy and chemotherapy

Cited by 176 publications

References 35 publications

Water‐Responsive Hybrid Nanoparticles Codelivering ICG and DOX Effectively Treat Breast Cancer via Hyperthermia‐aided DOX Functionality and Drug Penetration

Water‐Responsive Hybrid Nanoparticles Codelivering ICG and DOX Effectively Treat Breast Cancer via Hyperthermia‐aided DOX Functionality and Drug Penetration

A Porous Au@Rh Bimetallic Core–Shell Nanostructure as an H₂O₂‐Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy

Effects of Therapeutic and Toxic Agents on Erythrocytes of Different Species of Animals

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Nanoscaled red blood cells facilitate breast cancer treatment by combining photothermal/photodynamic therapy and chemotherapy

Cited by 176 publications

References 35 publications

Water‐Responsive Hybrid Nanoparticles Codelivering ICG and DOX Effectively Treat Breast Cancer via Hyperthermia‐aided DOX Functionality and Drug Penetration

Water‐Responsive Hybrid Nanoparticles Codelivering ICG and DOX Effectively Treat Breast Cancer via Hyperthermia‐aided DOX Functionality and Drug Penetration

A Porous Au@Rh Bimetallic Core–Shell Nanostructure as an H2O2‐Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy

Effects of Therapeutic and Toxic Agents on Erythrocytes of Different Species of Animals

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A Porous Au@Rh Bimetallic Core–Shell Nanostructure as an H₂O₂‐Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy