Nanoscience and Nanotechnology

Chattopadhyay, K.; Ghosh, Asoke Kumar

doi:10.1515/9783110547221

Cited by 5 publications

(1 citation statement)

References 29 publications

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“…The nanomaterial part of a nanomedicine formulation may be the active ingredient itself, a drug carrier, a novel excipient, or a drug complex/conjugate [4]. Nanomedicines include, but are not limited to, drug nanocrystals (e.g., olanzapine), liposomes (e.g., doxorubicin hydrochloride), polymeric drugs (e.g., glatiramer acetate), iron-polymer complexes (e.g., ferric carboxymaltose), virus-like particles (e.g., formalin inactivated hepatitis A virus) and virosomes (e.g., recombinant adenovirus expressing wildtype-p53) [5,6]. Between 1973 and 2015, liposomal agents were the most prevalent type of nanomedicine to be submitted for regulatory approval, followed by products containing nanocrystals, emulsions and iron-polymer complexes [4].…”

Section: Introductionmentioning

confidence: 99%

How Do Hospital Pharmacists Approach Substitution of Nanomedicines? Insights from a Qualitative Pilot Study and a Quantitative Market Research Analysis in Five European Countries

et al. 2021

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We conducted research to assess hospital pharmacists’ familiarity with/interpretation of data requirements for the different regulatory approval frameworks and the impact of this on their approach to substitution in the formulary. The online questionnaire included a small molecule (acetylsalicylic acid—follow-ons approved via the generic pathway), two biologic drugs (insulin glargine and etanercept—follow-ons approved via the biosimilar pathway), a non-biologic complex drug (NBCD; glatiramer acetate—follow-ons approved via the hybrid pathway) and a nanomedicine, ferric carboxymaltose (no follow-ons approved as yet). The study was conducted in two phases: an initial qualitative pilot study with 30 participants, followed by a quantitative stage involving 201 pharmacists from five European countries. Most expected negligible safety/efficacy differences between reference and follow-on products. Head-to-head clinical data showing therapeutic equivalence as a prerequisite for reference product/follow-on substitution was perceived to be needed most for biologics (47%), followed by NBCDs (44%)/nanomedicines (39%) and small molecules (23%). Overall, 28% did not know the data requirements for follow-on approval via the hybrid pathway; 16% were familiar with this pathway, compared with 50% and 55% for the generic and biosimilar pathways, respectively. Overall, 19% of respondents thought the European Medicines Agency (EMA) was responsible for defining the substitutability of follow-ons. Education is required to increase hospital pharmacist’s knowledge of regulatory approval frameworks and their relevance to substitution practices.

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Section: Introductionmentioning

confidence: 99%

How Do Hospital Pharmacists Approach Substitution of Nanomedicines? Insights from a Qualitative Pilot Study and a Quantitative Market Research Analysis in Five European Countries

et al. 2021

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Multifunctional composites with a polymer matrix containing carbon nanotubes: a study of structural, physicochemical and operational characteristics

Shao,

Bieliatynskyi,

Trachevskyi

et al. 2024

Fullerenes, Nanotubes and Carbon Nanostructures

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Socially-Tolerated Practices in Environmental and Social Impact Assessment Reporting: Discourses, Displacement, and Impoverishment

Ijabadeniyi

Vanclay

2020

Land

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Normative guidelines for addressing project-induced displacement and resettlement have been successful in coercing companies and practitioners to comply with international standards and local requirements. However, good practice has not always been effectively implemented, leading to reduced social wellbeing of people in local communities. We assess how the reciprocal relationships between institutional norms and practitioners’ situated perspectives about company-community interactions can improve social management practice. Drawing on Hajer and Versteeg’s method of environmental discourse analysis, discussions and storylines about a mining project in Mpumalanga in South Africa were assessed against contextualised discursive conventions in the mining industry. It was found that practitioners learn to manipulate legislative requirements, which ultimately perpetuates the impoverishment of project affected communities. The question is not whether or not practitioners understand the requirements of environmental and social management, but the extent to which such understandings are manipulated for corporate gain as opposed to social good. We consider practitioner rationalities about the purpose and function of environmental and social management, and how it is implemented. We suggest that practitioners and companies should construct positive aspirational identity perspectives about social management that would transcend from their current limited view (that achieving minimum compliance is sufficient) to aspiring to achieve better social development outcomes for all, especially the most disadvantaged. This requires a genuine commitment to obtaining and maintaining a social licence to operate, perspective transformation, a commitment to inclusiveness, and increased capacity for critical reflection.

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Nanoscience and Nanotechnology

Cited by 5 publications

References 29 publications

How Do Hospital Pharmacists Approach Substitution of Nanomedicines? Insights from a Qualitative Pilot Study and a Quantitative Market Research Analysis in Five European Countries

How Do Hospital Pharmacists Approach Substitution of Nanomedicines? Insights from a Qualitative Pilot Study and a Quantitative Market Research Analysis in Five European Countries

Multifunctional composites with a polymer matrix containing carbon nanotubes: a study of structural, physicochemical and operational characteristics

Socially-Tolerated Practices in Environmental and Social Impact Assessment Reporting: Discourses, Displacement, and Impoverishment

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