Nanoscience and Nanotechnology for Human Health

Müller, Bert; Voorde, Marcel Van de

doi:10.1002/9783527692057

Cited by 5 publications

(3 citation statements)

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“…Recent evidence also shows that PEGylation can elicit two potential responses upon administration, shown in Figure . ,− The first is a chronic immunogenic response leading to an accelerated blood clearance (ABC) of PEGylated systems. The second is an acute pseudoallergenic response leading to complement activation-related pseudoallergy (CARPA) and hypersensitivity reactions to PEGylated systems.…”

Section: Chemical Design Of Polymeric Cationic Vectorsmentioning

confidence: 99%

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Polymeric Delivery of Therapeutic Nucleic Acids

et al. 2021

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The advent of genome editing has transformed the therapeutic landscape for several debilitating diseases, and the clinical outlook for gene therapeutics has never been more promising. The therapeutic potential of nucleic acids has been limited by a reliance on engineered viral vectors for delivery. Chemically defined polymers can remediate technological, regulatory, and clinical challenges associated with viral modes of gene delivery. Because of their scalability, versatility, and exquisite tunability, polymers are ideal biomaterial platforms for delivering nucleic acid payloads efficiently while minimizing immune response and cellular toxicity. While polymeric gene delivery has progressed significantly in the past four decades, clinical translation of polymeric vehicles faces several formidable challenges. The aim of our Account is to illustrate diverse concepts in designing polymeric vectors towards meeting therapeutic goals of in vivo and ex vivo gene therapy. Here, we highlight several classes of polymers employed in gene delivery and summarize the recent work on understanding the contributions of chemical and architectural design parameters. We touch upon characterization methods used to visualize and understand events transpiring at the interfaces between polymer, nucleic acids, and the physiological environment. We conclude that interdisciplinary approaches and methodologies motivated by fundamental questions are key to designing high-performing polymeric vehicles for gene therapy.

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Section: Chemical Design Of Polymeric Cationic Vectorsmentioning

confidence: 99%

“…(B) Positive feedback cascade of PEGylated material activating the complement system (C activation) leading to CARPA and ABC. Reproduced with permission from ref . Copyright 2017 John Wiley and Sons.…”

Section: Chemical Design Of Polymeric Cationic Vectorsmentioning

confidence: 99%

Polymeric Delivery of Therapeutic Nucleic Acids

et al. 2021

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“…23 There are several attempts with limited progress to realise artificial sphincters on the basis of electroactive polymer actuators and devices, see e.g. [27][28][29][30][31][32][33][34][35][36] So far, HASEL technology has not been considered for the implementation into artificial sphincters for severe incontinence treatment. Therefore, the present study focuses on the HASEL principle for artificial muscles with the aim to demonstrate feasibility.…”

Section: Sphincter Devicesmentioning

confidence: 99%

In vitro testing of an artificial muscle for the treatment of incontinence

Lyko,

Gravert,

Katzschmann

et al. 2024

Electroactive Polymer Actuators and Devices (EAPAD) XXVI

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The burden of incontinence is profound, affecting individuals both physically and emotionally. Treatment pathways typically progress from conservative measures to surgical interventions, sometimes culminating in the implantation of artificial sphincters. The existing models including the AMS 800™ show high revision rates. Complications such as tissue erosion further underscore the need for innovation in this field. Here, we propose an approach utilizing Hydraulically Amplified Self-healing Electrostatic (HASEL) actuators to develop an advanced artificial urethral sphincter. By employing HASEL actuators arranged in a cuff configuration, we aim to address the limitations of current devices. Initial in vitro testing on porcine urethrae has shown promising results in controlling the water flow at a hydrostatic pressure of 20 cmH 2 O, demonstrating the feasibility to mimic sphincter function. This approach holds potential to significantly enhance the quality of life for patients suffering from incontinence as they regain control over their bodies. Further research and clinical trials are warranted to validate the efficacy and safety of this approach.

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Environmental and Toxicological Implications of Nanopharmaceuticals: An Overview

Verma

Ratan

2020

Nanopharmaceuticals: Principles and Applications Vol. 2

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Nanoscience and Nanotechnology for Human Health

Cited by 5 publications

References 0 publications

Polymeric Delivery of Therapeutic Nucleic Acids

Polymeric Delivery of Therapeutic Nucleic Acids

In vitro testing of an artificial muscle for the treatment of incontinence

Environmental and Toxicological Implications of Nanopharmaceuticals: An Overview

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