This chapter starts with an overview on the sustainable development crucial challenges. The ones directly or indirectly related to the field of civil engineering are highlighted. These include greenhouse gas emissions (GHG) related to the energy consumption of the built environment, aggravated by urbanization forecast expansion, and the recent increase in building cooling needs due to climate change. It also includes the depletion of nonrenewable raw materials and mining-related environmental risks in terms of biodiversity conservation, air pollution, and contamination of water reserves. Some shortcomings of engineering curriculum to address sustainable development challenges (especially civil engineering) are described. Possible contributions of biotechnologies and biomimetics to sustainable development and the rebirth of civil engineering curriculum are suggested. A book outline is also presented. 1.1 Sustainable Development Challenges Four decades ago several investigators used a computer model based on the fixedstock paradigm to study the interactions between population, food production, industrial production, pollution, and the consumption of nonrenewable resources. As a result, they predicted that during the twenty-first century the Earth's capacity would be exhausted resulting in the collapse of human civilization as we know it Meadows et al. (1972). Two decades after that an update of this study was published showing that some limits had already been crossed (Meadows et al. 1992). Rockström et al. (2009) recently proposed a new approach to global sustainability defining nine interdependent planetary boundaries within which they expect that humanity can operate safely. This include: