Nanoscopic behavior of polyvinylpyrrolidone particles on polysulfone/polyvinylpyrrolidone film

Hayama, Masayo; Yamamoto, Ken; Kohori, Fukashi; Uesaka, Tsutomu; Ueno, Yoshiyuki; Sugaya, Hiroyuki; Itagaki, Ichiro; Sakai, Kiyotaka

doi:10.1016/s0142-9612(03)00629-x

Cited by 93 publications

(64 citation statements)

References 15 publications

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“…However, most recent cases of dialysis-associated thrombocytopenia have been associated with PS membranes, especially electron beam-sterilized PS membranes [27]. Many PS membranes contain polyvinylpyrrolidone (PVP), which is incorporated into the membrane in varying amounts, both to increase hydrophilicity and affect the membrane's flux characteristics [28]. The biocompatibility of PS membranes varies according to the degree of added PVP, as well as other factors [28].…”

Section: Discussionmentioning

confidence: 99%

“…Many PS membranes contain polyvinylpyrrolidone (PVP), which is incorporated into the membrane in varying amounts, both to increase hydrophilicity and affect the membrane's flux characteristics [28]. The biocompatibility of PS membranes varies according to the degree of added PVP, as well as other factors [28]. Furthermore, recent studies suggest that PS is associated with unpleasant side effects including anaphylaxis and skin lesions, supposedly caused by PVP [29,30,31,32,33,34,35,36].…”

Section: Discussionmentioning

confidence: 99%

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High-Performance Membrane Dialyzers and Mortality in Hemodialysis Patients: A 2-Year Cohort Study from the Annual Survey of the Japanese Renal Data Registry

et al. 2017

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Background: Little information is available regarding the type of dialyzer which results in good prognosis. This study is aimed at investigating the association between 7 types of dialyzers and 2-year mortality. Methods: We conducted a cohort study using data from a nationwide registry of the Japanese Society for Dialysis Therapy. Subjects were 136,676 patients on maintenance hemodialysis (HD) between 2009 and 2011 who underwent maintenance HD for at least 2 years and were treated with one of the following 7 types of high-performance membrane dialyzers: cellulose triacetate (CTA), ethylene vinyl alcohol (EVAL), polyacrylonitrile (PAN), polyester polymer alloy (PEPA), polyethersulfone (PES), polymethylmethacrylate (PMMA), and polysulfone (PS). Cox regression was used to estimate the association between baseline dialyzers and all-cause 2-year mortality, adjusting for potential confounders. Results: Data were adjusted using basic factors, with PS as a reference group, and the hazard ratio (HR) was significantly higher in CTA, PMMA, PAN, and EVAL groups. Further data adjustment for Kt/V yielded the same results as were obtained from data adjusted for basic factors. After further adjustment for nutrition- and inflammation-related factors, HR was significantly lowered for the PES and PMMA groups compared with the PS group (HR 0.88; 95% CI 0.82-0.94 and HR 0.84 95% CI 0.76-0.93, respectively). After propensity score matching, HR for the PES and PMMA groups was significantly lowered compared with the PS group. Conclusions: The use of different membrane types may affect mortality. Further long-term prospective studies are needed to clarify whether the PES and PMMA membranes can improve prognosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

High-Performance Membrane Dialyzers and Mortality in Hemodialysis Patients: A 2-Year Cohort Study from the Annual Survey of the Japanese Renal Data Registry

et al. 2017

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“…Similarly, the roughness of PS membranes is associated with albumin adsorption [23]. For membranes containing PVP, the smoothness, softness, and even physical properties of the membrane materials depend on the type and amount of PVP in the membrane [24]. Through coating and surface modification, not only the chemical composition of the membrane material, but also the physical properties such as smoothness and softness of the surface are altered, which in turn alters the effect on platelets and leukocytes.…”

Section: Newly Developed Dialysis and Filtration Membranesmentioning

confidence: 99%

Evaluation of the Biocompatibility of Dialysis Membranes

Kokubo

Kurihara²,

Kobayashi³

et al. 2015

Blood Purif

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Background: Improvements in the biocompatibility of dialysis membranes have reduced biological responses elicited by blood-membrane interactions. In this article, recent technological developments in dialysis membranes with regard to biocompatibility and recent progress in the evaluation of the biocompatibility of dialysis membranes are reviewed. Summary: The focus of investigation into dialysis membranes in recent years has focused on not only membrane materials, but also their surface textures, which have been changed, for example, by coating with vitamin E or by changing the amount and type of hydrophilizing agents used. Research and development is directed at altering the chemical and physical properties of membrane surfaces to suppress biological responses that are particularly elicited as a result of platelet activation. To develop membranes with excellent biocompatibility, biocompatibility should be evaluated on a like-for-like basis under conditions that are similar to those in clinical settings. Evaluation using actual dialyzers can be performed using porcine blood, platelet-rich plasma isolated from porcine blood (and platelet-rich plasma with leukocytes), or suspension of neutrophils isolated from porcine blood or cultured human monocytes. Key Messages: Highly biocompatible dialysis membranes can be developed when the overall correlations among biological reactions are examined by integrating all data on biological responses elicited by blood-membrane interactions or mutual interactions among blood cells.

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“…Hayama et al reported that the surface roughness of PSF films was approximately the same as our value (R ms ¼ 1.2 nm) by AFM observation. 25 The AFM observation also supported a homogeneous monolayer adsorption of hTM onto the PSF film.…”

Section: Qcm Analyses Of Htm and Proteins Adsorption Onto Psf Filmsmentioning

confidence: 58%

“…PSF is the main component of hemodialyzer membranes, but polyvinylpyrrolidone (PVP) is generally blended with the PSF to improve the hydrophilicity and biocompatibility of the hydrophobic PSF. 25 Because of its hydrophobic properties (static contact angle 988), blood clots were formed on the PSF film within 20 min. On the other hand, we selected Lys-adsorbed PSF films with approximately the same hydrophilicity (both static contact angles of Lys-and hTM-adsorbed PSF films were 678 by controlling the surface coverage of both proteins at 30% (Table II)) as a control to clearly evaluate the anticoagulant activity of the hTM-adsorbed PSF films independently of their hydrophilic and hydrophobic properties.…”

Section: Ftir-ras Observation Of Htm Adsorbed Onto Psf Filmsmentioning

confidence: 99%

Physical adsorption of human thrombomodulin (ART‐123) onto polymeric biomaterials for developing an antithrombogenic blood‐contacting material

Matsusaki

Omichi

Maruyama

et al. 2007

J Biomedical Materials Res

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Human thrombomodulin (hTM) is an endothelial cell-associated protein with potent natural anticoagulant activity by converting thrombin from a procoagulant protease to an anticoagulant. ART-123 is a recombinant soluble hTM (amino acid residues 1-498), and we focused on the physical adsorption of ART-123 onto a polymeric biomaterial surface to develop an antithrombogenic blood-contacting material with preventing the denaturation of hTM and the remaining chemical reagents. The adsorption of hTM onto polysulfone (PSF) films was analyzed quantitatively by quartz crystal microbalance analysis. The adsorption constant and the maximum adsorption amount, calculated by the assumption of a Langmuir-type adsorption, showed that hTM adsorbed with a relatively weak interaction onto the PSF film. The hydrophilic protein lysozyme also showed a Langmuir-type monolayer adsorption, although hydrophobic catalase and fibrinogen showed multilayer adsorption accompanying the denaturation. The physically adsorbed hTM showed high coenzymatic activity for the activation of protein C, as well as anticoagulant activity. Furthermore, the surface wettability of the PSF film was easily controllable by the physical adsorption of hydrophobic and hydrophilic bioactive proteins. The physical adsorption of hTM or bioactive proteins onto polymeric biomaterials will be instrumental for developing an antithrombogenic blood-contacting biomaterial, and for controlling the surface properties of biomaterials.

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Nanoscopic behavior of polyvinylpyrrolidone particles on polysulfone/polyvinylpyrrolidone film

Cited by 93 publications

References 15 publications

High-Performance Membrane Dialyzers and Mortality in Hemodialysis Patients: A 2-Year Cohort Study from the Annual Survey of the Japanese Renal Data Registry

High-Performance Membrane Dialyzers and Mortality in Hemodialysis Patients: A 2-Year Cohort Study from the Annual Survey of the Japanese Renal Data Registry

Evaluation of the Biocompatibility of Dialysis Membranes

Physical adsorption of human thrombomodulin (ART‐123) onto polymeric biomaterials for developing an antithrombogenic blood‐contacting material

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