Nanoscopic tumor tissue distribution of platinum after intraperitoneal administration in a xenograft model of ovarian cancer

Carlier, Charlotte; Laforce, Brecht; Malderen, Stijn J. M. Van; Gremonprez, Félix; Tucoulou, R.; Villanova, Julie; Wever, Olivier De; Vincze, László; Vanhaecke, Frank; Ceelen, Wim

doi:10.1016/j.jpba.2016.09.004

Cited by 26 publications

(14 citation statements)

References 28 publications

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“…There are several LA-ICP-MS studies reporting on the platinum distribution of cisplatin, oxaliplatin and satraplatin in tumor tissue. 35–37 For oxaliplatin, elevated platinum levels were mainly observed at the edge of tumor tissue and in areas with connective tissue, 35–37 whereas in the present study, platinum was evenly distributed in the tumor tissue after oxaliplatin treatment. The platinum pattern correlated with the phosphorus and sulfur distribution.…”

Section: Resultscontrasting

confidence: 64%

Albumin-targeting of an oxaliplatin-releasing platinum(iv) prodrug results in pronounced anticancer activity due to endocytotic drug uptake in vivo

et al. 2021

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Section: Resultscontrasting

confidence: 64%

Albumin-targeting of an oxaliplatin-releasing platinum(iv) prodrug results in pronounced anticancer activity due to endocytotic drug uptake in vivo

et al. 2021

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“…Most tissues, including tumors, are composed of areas of different matricellular composition and functional importance; this heterogeneity translates into differences in the distribution of affinity-targeted payloads 23,24. Laser ablation (LA) ICP-MS was originally established for spatially-defined isotopic detection in geological and archeological samples25 and used later to study elemental distribution in sections of biological tissues,26–29 including tumors 30,31. To study spatial distribution of AgNP in tissues we dosed mice with a cocktail of RPARPAR-Ag107NPs and non-targeted biotin-Ag109NPs followed by perfusion and collection of organs after 5 h, cryosections of the tissues were subjected to LA-ICP-MS analysis.…”

Section: Resultsmentioning

confidence: 99%

Ratiometric in vivo auditioning of targeted silver nanoparticles

et al. 2017

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Attaching affinity ligands to nanoparticles (NPs) increases selectivity for targeting cells and tissues, and can result in improved sensitivity and reduced off-target toxicity in diagnostic and therapeutic systems. The decision over key features – NP size, shape, coating strategies and targeting ligands for clinical translation is often hampered by a lack of quantitative in vivo NP homing assays. Sensitive, internally controlled assays are needed which allow for quantitative comparisons (auditions) among various formulations of targeted NPs. We recently reported the development of peptide-functionalized, isotopically-barcoded silver NPs (AgNPs) for ultrasensitive studies centered on measuring relative ratios of NP internalization into cultured cells. Here we evaluated the application of this technology for NP homing studies in live mice using peptides with previously described tissue tropism; one peptide that favors vascular beds of the normal lungs (RPARPAR; receptor neuropilin-1, or NRP-1) and another that is selective for central nervous system vessels (CAGALCY). Equimolar mixtures of the peptide-targeted Ag107-NPs and Ag109 control particles were mixed and injected intravenously. Distribution profiles of Ag107 and Ag109 in tissue extracts were determined simultaneously through inductively coupled plasma mass spectrometry (ICP-MS). Compared to non-targeted particles up to ~9-fold increased lung accumulation was seen for RPARPAR-OH AgNPs (but not for AgNPs functionalized with RPARPAR-NH2, which does not bind to NRP-1). Similarly, AgNPs functionalized with the brain-homing CAGALCY peptide were overrepresented in brain extracts. Spatial distribution (mapping) analysis by laser ablation ICP-MS (LA-ICP-MS) was used to determine the ratio Ag107/Ag109 in tissue cryosections. The mapping demonstrated preferential accumulation of the RPARPAR-AgNPs in the perivascular areas around pulmonary veins, and CAGALCY AgNPs accumulated in discrete areas of the brain (e.g. in the vessels of cerebellar fibrillary tracts). Based on these results, the internally controlled ratiometric AgNP system is suitable for quantitative studies of the effect of targeting ligands on NP biodistribution, at average tissue concentration and distribution at the microscopic level. The platform might be particularly relevant for target sites with high local variability in uptake, such as tumors.

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“…The following rat types were used in the analyzed articles; Wistar (21%) [ 32 , 45 , 46 , 62 , 63 , 64 ], Sprague Dawley (32%) [ 40 , 43 , 51 , 52 , 57 , 65 , 66 , 67 , 68 ], WAG/Rij (32%) [ 47 , 54 , 69 , 70 , 71 , 72 , 73 , 74 , 75 ] and athymic/nude (14%) [ 44 , 76 , 77 , 78 ] rats. For mouse experiments, the following strains were used: Swiss albino (20%) [ 36 , 38 , 79 ], athymic (33%) [ 37 , 48 , 50 , 55 , 80 ], C57BL/6 (20%) [ 33 , 39 , 81 ], BALB/c (20%) [ 49 , 56 , 82 ] and NOD-SCID (7%) [ 34 ]. The following pig strains were used: white (38%) [ 58 , 60 , 61 , 83 , 84 ], sus scrofa domesticus (23%) [ 85 , 86 , 87 …”

Section: Preclinical Hipec Modelsmentioning

confidence: 99%

“…In the included articles, PM was induced in rats (46%), mice (100%) and rabbits (66%) before HIPEC treatment. Most PM models were syngeneic (69%) [ 32 , 33 , 35 , 36 , 38 , 39 , 41 , 42 , 44 , 45 , 47 , 49 , 54 , 56 , 64 , 69 , 70 , 72 , 73 , 74 , 79 ], whereas xenograft (28%) [ 34 , 37 , 48 , 50 , 55 , 78 , 80 , 81 ] and patient derived xenograft (PDX) (3%) [ 77 ] models were used in only 9 of the 29 used models. Tumors were established from different cell lines originating from colorectal (45%) [ 39 , 44 , 47 , 49 , 50 , 54 , 55 , 56 , 69 , 70 , 72 , 73 , 74 , 82 ], ovarian (29%) [ 32 , 33 , 37 , 45 , 48 , 64 , 78 ...…”

Section: Preclinical Hipec Modelsmentioning

confidence: 99%

Preclinical In Vivo-Models to Investigate HIPEC; Current Methodologies and Challenges

Helderman

Löke

Tanis

et al. 2021

Cancers

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Hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment modality for patients with peritoneal metastasis (PM) of various origins which aims for cure in combination with cytoreductive surgery (CRS). Efficacy of CRS-HIPEC depends on patient selection, tumor type, delivery technique, and treatment parameters such as temperature, carrier solution, type of drug, dosage, volume, and treatment duration. Preclinical research offers a powerful tool to investigate the impact of these parameters and to assist in designing potentially more effective treatment protocols and clinical trials. The different methodologies for peritoneal disease and HIPEC are variable. This study aims to review the objectives, methods, and clinical relevance of in vivo preclinical HIPEC studies found in the literature. In this review, recommendations are provided and possible pitfalls are discussed on the choice of type of animal and tumor model per stratified parameters and study goal. The guidelines presented in this paper can improve the clinical relevance and impact of future in vivo HIPEC experiments.

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Nanoscopic tumor tissue distribution of platinum after intraperitoneal administration in a xenograft model of ovarian cancer

Cited by 26 publications

References 28 publications

Albumin-targeting of an oxaliplatin-releasing platinum(iv) prodrug results in pronounced anticancer activity due to endocytotic drug uptake in vivo

Albumin-targeting of an oxaliplatin-releasing platinum(iv) prodrug results in pronounced anticancer activity due to endocytotic drug uptake in vivo

Ratiometric in vivo auditioning of targeted silver nanoparticles

Preclinical In Vivo-Models to Investigate HIPEC; Current Methodologies and Challenges

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