Nanosheets anchored ultrasmall nanoimmunosensitizers-triggered collaborative multienzyme-mimicking cascade reactions disrupt spatiotemporal heterogeneous metabolism to sensitize mastocarcinoma immunotherapy

Zhuang, Liang; Wang, Pingfei; Song, Kai; He, Shan; Meng, Tong; Zhang, Guiju; Guan, Shanyue; Xu, Baocai

doi:10.1016/j.cej.2024.154500

Chemical Engineering Journal

2024

DOI: 10.1016/j.cej.2024.154500

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Nanosheets anchored ultrasmall nanoimmunosensitizers-triggered collaborative multienzyme-mimicking cascade reactions disrupt spatiotemporal heterogeneous metabolism to sensitize mastocarcinoma immunotherapy

Liang Zhuang,

Pingfei Wang,

Kai Song

et al.

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Cited by 3 publications

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Exploring the interaction between black phosphorus (BP)-based hybrid systems and target proteins is of great significance for understanding the biological effects of 2D nanomaterials at the molecular level. Density functional theory (DFT) calculations revealed that different terminal groups of the azobenzene (AB) motif in BP@AB hybrids can affect the extent of interfacial charge transfer between the BP sheet and ABderivatives, which determines the electrostatic interaction with proteins and hence biofunctions of BP@AB hybrids. With the advantage of AB modification, BP@AB hybrids displayed antitumor effects and induced production of cellular reactive oxygen species and apoptosis in cancer cells. Through the proteomics profiling, cellular ribosome and lipid metabolic processes were screened out as the target pathways of the

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Nanosheets anchored ultrasmall nanoimmunosensitizers-triggered collaborative multienzyme-mimicking cascade reactions disrupt spatiotemporal heterogeneous metabolism to sensitize mastocarcinoma immunotherapy

Cited by 3 publications

References 67 publications

Construction of acidic microenvironment by Cu-TCPP nanozyme composited deprotonatable polymeric nanofibers for efficient antibacterial activity

Construction of acidic microenvironment by Cu-TCPP nanozyme composited deprotonatable polymeric nanofibers for efficient antibacterial activity

Interlayer-engineered “six-in-one” nanozymes for cascade enzymatic/photothermal oncotherapy

Study of Azobenzene-modified Black Phosphorus for Potential Tumor Therapy

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