Nanosheets and 2D-nanonetworks by mutually assisted self-assembly of fullerene clusters and DNA three-way junctions

Vittala, Sandeepa Kulala; Saraswathi, Sajena Kanangat; Ramesan, Anjali Bindu; Joseph, Joshy

doi:10.1039/c9na00485h

Cited by 12 publications

(14 citation statements)

References 66 publications

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“…(F) Scheme and (i) AFM and (ii) TEM images of fullerene clusters in the presence of 3WJ-DNA. Reproduced with permission from refs and , respectively. Copyright 2018 and 2019 Royal Society of Chemistry.…”

Section: Fullerene-dna Hybrid Materialsmentioning

confidence: 99%

“…Moreover, fullerene clusters and CT-DNA showed chiral templated assemblies resulted from the formation of nanofibrous structures (Figure E) . Recently, the same group utilized the differential interactions of fullerene clusters with branched Y-shaped DNA to construct DNA-fullerene hybrid micrometer-sized nanosheets (Figure F) . Although the rapid development of DNA-guided fullerene assembly has enabled fabrication of variety of nanostructures, the selective organization of fullerenes on DNA templates is still a challenge.…”

Section: Fullerene-dna Hybrid Materialsmentioning

confidence: 99%

“…80 Recently, the same group utilized the differential interactions of fullerene clusters with branched Y-shaped DNA to construct DNA-fullerene hybrid micrometer-sized nanosheets (Figure 3F). 81 Although the rapid development of DNA-guided fullerene assembly has enabled fabrication of variety of nanostructures, the selective organization of fullerenes on DNA templates is still a challenge. Moreover, the construction of fullerene-DNA structures to bridge between the electrodes for conductivity measurement is still difficult with current methods, which further hinders the development of applications of fullerene-DNA hybrid materials.…”

Section: Organizationmentioning

confidence: 99%

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DNA-Guided Assemblies toward Nanoelectronic Applications

Vittala

Han

2020

ACS Appl. Bio Mater.

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Programmable DNA-guided self-assembly of nanoscale functional materials is of great interest in the context of nanofabrication or nanoelectronics. Attributed to its unique sequence programmability and precisely defined dimension, DNA has been used as a template for constructing ordered one-, two-, and three-dimensional architectures with organic, inorganic, and polymeric building blocks via various self-assembly strategies. Moreover, the accessible integration capability of DNA with diverse electronics-related materials propels the field of DNA-guided assemblies toward nanoelectronic applications. In this review, we outline the development in the area of DNA-guided assemblies that are constructed from carbon nanotubes, fullerenes, polymers, metals, metal oxides, and minerals using various strategies, with the focus on the bottom-up DNA-guided conducting, semiconducting, and insulating nanomaterials applied on nanoelectronics. We also review some bottom-up and top-down hybrid methods that precisely immobilize functional DNA-guided materials on substrates with high throughput. Finally, we describe the challenges in nanofabrication and potential applications of DNA-guided assemblies in nanoelectronics.

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Section: Fullerene-dna Hybrid Materialsmentioning

confidence: 99%

Section: Fullerene-dna Hybrid Materialsmentioning

confidence: 99%

Section: Organizationmentioning

confidence: 99%

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DNA-Guided Assemblies toward Nanoelectronic Applications

Vittala

Han

2020

ACS Appl. Bio Mater.

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“…In the recent years, increasing attention has been devoted to DNA templated assemblies due to their unparalleled selfassembly and programmability properties for the precession guided nanomaterial fabrication. [1][2][3][4][5][6][7][8] For instance, the bottomup DNA-guided assemblies were utilized to integrate several functional electronic materials such as carbon nanotubes, [9][10][11] fullerenes, [12][13] polymers, [14][15][16] metals, [17][18][19] nanoclusters [20][21][22] with various DNA interaction strategies. Moreover, the programmed assembly of DNA was used to construct arbitrary shapes and patterns which intern utilized as higher order template for hierarchical organization of metallized nanowires, nanoarrays and biomaterials.…”

Section: Introductionmentioning

confidence: 99%

Programmed Assembly of DNA Templates by Silver Nanowires

2022

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DNA origami templates are known to exhibit many advantages to integrate functional components at desirable locations for nanoelectronic applications. In order to immobilize conducting or semiconducting species in a bottom-up approach, the programmed assembly of DNA templates is of utmost necessity. This report demonstrates the silver nanowires enabled bridging of two linear DNA origami (DO) nanostructures by utilizing the host-guest interaction of biotin-STV and sequence-specific silver metallization of poly(dG-dC) DNA nanowires (in 10 % yield) using (dA) 10 coated AgNPs (15 nm). The enzymatic synthesis of 750 bp, 1500 bp and 3000 bp bis-biotinylated poly(dG-dC), facile synthesis of 1 : 1 biotin-STV and silver-nanowire bridged DNA templates were characterized by gel electrophoresis, atomic force microscope imaging techniques. The strategy utilized here provides a method that can precisely connect heterogeneous templates towards bottom-up fabrication of practical nanoelectronics. www.chempluschem.org

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“…Functionalized fullerene derivatives are well explored and investigated for in vitro DNA condensation and in vivo gene delivery applications (Nakamura and Isobe, 2010;Minami et al, 2018). Recently, we have demonstrated a fullerene cluster assisted self-assembly of short DNA double strands into nanowires, DNA three-way junction structures into nanosheets and 2-dimensional nanonetworks, and the chiral organization of fullerene clusters on CT-DNA templates followed by concentration-dependent DNA condensation process (Vittala et al, 2017;Kulala Vittala and Joseph, 2018;Vittala et al, 2019). Here, we employed the unique hydrophilichydrophobic balance in the molecular structure of an anilinefunctionalized fullerene derivative, F-An, in a 10% DMSO-PBS solvent system to prepare 3-5 nm fullerene nanoclusters, and their interactions with different DNA structures were demonstrated.…”

Section: Introductionmentioning

confidence: 99%

DNA Condensation Triggered by the Synergistic Self-Assembly of Tetraphenylethylene-Viologen Aggregates and CT-DNA

et al. 2021

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Development of small organic chromophores as DNA condensing agents, which explore supramolecular interactions and absorbance or fluorescence-based tracking of condensation and gene delivery processes, is in the initial stages. Herein, we report the synthesis and electrostatic/groove binding interaction–directed synergistic self-assembly of the aggregates of two viologen-functionalized tetraphenylethylene (TPE-V) molecules with CT-DNA and subsequent concentration-dependent DNA condensation process. TPE-V molecules differ in their chemical structure according to the number of viologen units. Photophysical and morphological studies have revealed the interaction of the aggregates of TPE-V in Tris buffer with CT-DNA, which transforms the fibrous network structure of CT-DNA to partially condensed beads-on-a-string-like arrangement with TPE-V aggregates as beads via electrostatic and groove binding interactions. Upon further increasing the concentration of TPE-V, the “beads-on-a-string”-type assembly of TPE-V/CT-DNA complex changes to completely condensed compact structures with 40–50 nm in diameter through the effective charge neutralization process. Enhancement in the melting temperature of CT-DNA, quenching of the fluorescence emission of ethidium bromide/CT-DNA complex, and the formation of induced CD signal in the presence of TPE-V molecules support the observed morphological changes and thereby verify the DNA condensation abilities of TPE-V molecules. Decrease in the hydrodynamic size, increase in the zeta potential value with the addition of TPE-V molecules to CT-DNA, failure of TPE-V/cucurbit(8)uril complex to condense CT-DNA, and the enhanced DNA condensation ability of TPE-V2 with two viologen units compared to TPE-V1 with a single viologen unit confirm the importance of positively charged viologen units in the DNA condensation process. Initial cytotoxicity analysis on A549 cancer and WI-38 normal cells revealed that these DNA condensing agents are non-toxic in nature and hence could be utilized in further cellular delivery studies.

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Nanosheets and 2D-nanonetworks by mutually assisted self-assembly of fullerene clusters and DNA three-way junctions

Abstract: Self-assembly of F-An nanoclusters with 3WJ-DNA and 3WJ-OH offers nanosheets and entangled 2D-nanonetworks, respectively. 3WJ-OH/F-An in the presence of AgNCs shows enhanced fluorescence (∼40%) due to its stabilization in the 2D-nanonetworks.

Cited by 12 publications

References 66 publications

DNA-Guided Assemblies toward Nanoelectronic Applications

DNA-Guided Assemblies toward Nanoelectronic Applications

Programmed Assembly of DNA Templates by Silver Nanowires

DNA Condensation Triggered by the Synergistic Self-Assembly of Tetraphenylethylene-Viologen Aggregates and CT-DNA

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