Nanosilica and Polyacrylate/Nanosilica: A Comparative Study of Acute Toxicity

Abstract

We compared the acute toxicity of nanosilica and polyacrylate/nanosilica instillation in Wistar rats (n = 60). Exposure to nanosilica and polyacrylate/nanosilica showed a 30% mortality rate. When compared with saline-treated rats, animals in both exposure groups exhibited a significant reduction of PO2 (P < 0.05) at both 24 and 72 hr. after exposure. Both exposure groups exhibited a significant reduction of neutrophils in arterial blood compared to saline controls (P < 0.05) 24 hr. after exposure. The levels of blood ALT and LDH in exposed groups were found to be significantly increased (P < 0.05) 24 hr. following exposure. The exposed groups exhibited various degrees of pleural effusion and pericardial effusion. Our findings indicated respiratory exposure to polyacrylate/nanosilica and nanosilica is likely to cause multiple organ toxicity.

Carbon Nanotubes and Other Engineered Nanoparticles Induced Pathophysiology on Mesothelial Cells and Mesothelial Membranes

“…Due to the inappropriate workplace conditions and the lack of protective gear, the degree to which nanoparticle exposure was responsible for the aforementioned observations was debatable. That being said, the findings were replicated in a rat model of intratracheal instillation of the same polyacrylate/nanosilica, further supporting the notion that some inhaled nanoparticles may be associated with pleural pathology (i.e., effusions, inflammation, fibrosis) (Niu et al, 2016 ; Zhu et al, 2016 ).…”

Silica nanoparticles induce pulmonary damage in rats via VEGFC/D–VEGFR3 signaling-mediated lymphangiogenesis and remodeling

“…[6,8,30,31] Previous studies have indicated that SiNPs exposure induces pleural and pericardial effusion, pulmonary brosis, and granuloma in rats, which is similar to the symptoms observed in exposed workers. [9,10,32] However, the underlying pathological mechanism of SiNPs remains unknown. The results of this study show that SiNPs cause increased pulmonary in ammation and permeability, LEC damage, and pulmonary lymphangiogenesis and remodeling by activating the VEGFC/D-VEGFR3 signaling pathway.…”

β-CaSiO3 and colloidal n-SiO2 based blended cement composites- their properties, regression analysis and micro-characterization studies

“…The main advantages of using colloidal n-SiO 2 are high volume to surface area (7,8) and no harm to humans. The powdered form of n-SiO 2 gives better results than the colloidal form but is very harmful to human health (9). The colloidal n-SiO 2 also has excellent dispersion properties and can be distributed evenly throughout the mix if applied correctly.…”