Nanosolvation‐Induced Stabilization of a Protonated Peptide Dimer Isolated in the Gas Phase

Milosavljević, Aleksandar R.; Cerovski, Viktor Z.; Canon, Francis; Nahon, Laurent; Giuliani, Alexandre

doi:10.1002/anie.201301667

Cited by 15 publications

(7 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This series starts with the protonated HCNH (or CO) molecular fragment bound to an increasing number of water molecules, marked as (HCNH)(H VUV photoactivation tandem mass spectra of nanosolvated and protonated Leu-Enk peptide dimer ion, even if the hydration mostly increases the stability of the dimer. 68 According to the theoretical work of Wang et al, 69 there are four, hydrophilic, hydration sites in the uracil molecule, namely in the regions of N1-C2, C2-N3, N3-C4 and C4-C5, where the water molecules participate in the formation of two H-bonds with two adjacent H/O atoms of uracil. In addition, DFT calculations have demonstrated that the lowest energy configuration corresponds to uracil interacting with a water cluster in position N1-C2 for cases up to 3 water molecules.…”

Section: Formation Of Hydrated Fragmentsmentioning

confidence: 99%

The role of the environment in the ion induced fragmentation of uracil

Markush

Bolognesi

Cartoni

et al. 2016

Phys. Chem. Chem. Phys.

View full text Add to dashboard Cite

The fragmentation of uracil molecules and pure and nano-hydrated uracil clusters by (12)C(4+) ion impact is investigated. This work focuses on the fragmentation behavior of complex systems and the effect of the environment. On the one hand, it is found that the environment in the form of surrounding uracil or water molecules has a significant influence on the fragmentation dynamics, providing an overall 'protective' effect, while on the other hand we observe the opening of specific fragmentation channels. In particular, we report on the first observation of a series of hydrated fragments. This indicates a strong interaction between uracil and water molecules, holding the water clusters bound to the observed molecular fragments.

show abstract

Section: Formation Of Hydrated Fragmentsmentioning

confidence: 99%

The role of the environment in the ion induced fragmentation of uracil

Markush

Bolognesi

Cartoni

et al. 2016

Phys. Chem. Chem. Phys.

View full text Add to dashboard Cite

show abstract

“…Theoretical calculations on leukine encephaline protonated peptide have located the HOMO on the aromatic amino acids. 31 Although the IE is not known for all amino acids, 32 methionine is expected to have the lowest vertical IE at 8.65 eV (ref. 33) among the constitutive amino acids of substance P. The difference between the IE of the neutral amino acid and the present (adiabatic) measurement is ascribed to the Coulombic effect of the extra charge added upon protonation.…”

Section: Ionization Energy Of Substance Pmentioning

confidence: 99%

Action spectroscopy of a protonated peptide in the ultraviolet range

Canon

Milosavljević

Nahon

et al. 2015

Phys. Chem. Chem. Phys.

Self Cite

View full text Add to dashboard Cite

Action spectroscopy of protonated substance P, a model undecapeptide, has been probed from 5.2 eV to 20 eV. For photon energy above the ionization threshold measured at 10.3 ± 0.1 eV, the radical dication is observed along with side chain losses and abundant formation of all kinds of sequence ions. Below the photoionization threshold, the photoproducts involve side chain cleavages and backbone cleavages into a-, b-/y-, and c-sequence ions. Different electronic excited states appear to produce different fragment ions. Norrish type I and II reactions are proposed to account for some photoproducts. This study bridges the gap between laser activation and electron-induced dissociation of peptides. Moreover, our results report for the first time a comprehensive picture of the photochemical fragmentation of a gas phase peptide in a wide photon energy range.

show abstract

“…1) and has been intensively investigated in recent years to become a standard model in mass spectrometry 15 . Recently, we have also investigated VUV photon interaction with both bare and nanosolvated Leu-enk dimers 16,17 . We have measured the backbone photofragment yields and thus mapped the electronic excitation bands for the Leu-enk dimer molecule that lead to molecular dissociation 17 .…”

mentioning

confidence: 99%

VUV action spectroscopy of protonated leucine-enkephalin peptide in the 6-14 eV range

Ranković

Canon

Nahon

et al. 2015

The Journal of Chemical Physics

View full text Add to dashboard Cite

We have studied the Vacuum Ultraviolet (VUV) photodissociation of gas-phase protonated leucine-enkephalin peptide ion in the 5.7 to 14 eV photon energy range by coupling a linear quadrupole ion trap with a synchrotron radiation source. We report VUV activation tandem mass spectra at 6.7, 8.4, and 12.8 eV photon energies and photodissociation yields for a number of selected fragments. The obtained results provide insight into both near VUV radiation damage and electronic properties of a model peptide. We could distinguish several absorption bands and assign them to particular electronic transitions, according to previous theoretical studies. The photodissociation yields appear to be very different for the various observed fragmentation channels, depending on both the types of fragments and their position along the peptide backbone. The present results are discussed in light of recent gas-phase spectroscopic data on peptides.

show abstract

Nanosolvation‐Induced Stabilization of a Protonated Peptide Dimer Isolated in the Gas Phase

Cited by 15 publications

References 31 publications

The role of the environment in the ion induced fragmentation of uracil

The role of the environment in the ion induced fragmentation of uracil

Action spectroscopy of a protonated peptide in the ultraviolet range

VUV action spectroscopy of protonated leucine-enkephalin peptide in the 6-14 eV range

Contact Info

Product

Resources

About