Nanosponges: An overlooked promising strategy to combat SARS-CoV-2

Mostafavi, Ebrahim; Iravani, Siavash; Varma, Rajender S.

doi:10.1016/j.drudis.2022.07.015

Cited by 9 publications

(4 citation statements)

References 90 publications

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“…Nanosponges are also self-sterilizable because their typical pore size is 0.25 micron, which bacteria cannot penetrate (Potdar et al 2022 ). In order to restrict COVID-19 fungi co-infections, nanosponges have been employed against SARS-CoV-2 and have demonstrated potential inhibitory effects for biological neutralization and antiviral medication delivery applications (Mostafavi et al 2022 ). Furthermore, such cellular nanosponges may be useful for biological neutralization of chemical toxic agents, inflammatory cytokines, bacterial toxins, virus fragments, and pathological antibodies (Wang et al 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Nanosponge hydrogel of octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate of Alcaligenes faecalis

El-Sayed,

Abdelaziz,

El-Housseiny

et al. 2024

Appl Microbiol Biotechnol

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Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate (ODHP) was extracted in a previous study from the culture broth of soil isolate Alcaligenes faecalis MT332429 and showed a promising antimycotic activity. This study was aimed to formulate ODHP loaded β-cyclodextrins (CD) nanosponge (NS) hydrogel (HG) to control skin fungal ailments since nanosponges augment the retention of tested agents in the skin. Box-Behnken design was used to produce the optimized NS formulation, where entrapment efficiency percent (EE%), polydispersity index (PDI), and particle size (PS) were assigned as dependent parameters, while the independent process parameters were polyvinyl alcohol % (w/v %), polymer-linker ratio, homogenization time, and speed. The carbopol 940 hydrogel was then created by incorporating the nanosponges. The hydrogel fit Higuchi’s kinetic release model the best, according to in vitro drug release. Stability and photodegradation studies revealed that the NS-HG remained stable under tested conditions. The formulation also showed higher in vitro antifungal activity against Candida albicans compared to the control fluconazole. In vivo study showed that ODHP-NS-HG increased survival rates, wound contraction, and healing of wound gap and inhibited the inflammation process compared to the other control groups. The histopathological examinations and Masson’s trichrome staining showed improved healing and higher records of collagen deposition. Moreover, the permeability of ODHP-NS-HG was higher through rats’ skin by 1.5-folds compared to the control isoconazole 1%. Therefore, based on these results, NS-HG formulation is a potential carrier for enhanced and improved topical delivery of ODHP. Our study is a pioneering research on the development of a formulation for ODHP produced naturally from soil bacteria. Key points • Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate was successfully formulated as a nanosponge hydrogel and statistically optimized. • The new formula exhibited in vitro good stability, drug release, and higher antifungal activity against C. albicans as compared to the fluconazole. • Ex vivo showed enhanced skin permeability, and in vivo analysis showed high antifungal activity as evidenced by measurement of various biochemical parameters and histopathological examination.

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Section: Discussionmentioning

confidence: 99%

Nanosponge hydrogel of octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate of Alcaligenes faecalis

El-Sayed,

Abdelaziz,

El-Housseiny

et al. 2024

Appl Microbiol Biotechnol

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“…The use of nanosponges in environmental remediation can lead to more efficient and sustainable solutions for cleaning up contaminated sites and protecting the environment. 8,86,87 The future of nanosponges also lies in their integration with other materials and technologies. The integration of nanosponges with renewable energy sources, such as solar cells, can lead to more efficient and sustainable energy conversion and storage systems.…”

Section: Future Of Nanospongesmentioning

confidence: 99%

“…Nanosponges are three-dimensional (3D) porous materials composed of a network of interconnected nanoscale particles, which can be synthesized using various methods, including templating, self-assembly, and sol-gel processes. [7][8][9] The nanosponge structure allows for efficient mass transport and high surface area for catalytic reactions, while the tunable chemical composition can be tailored to optimize the catalytic activity and selectivity. 10,11 Nanosponges can be synthesized using various methods, including templating, 12 self-assembly, 13 and sol-gel processes.…”

Section: Introductionmentioning

confidence: 99%

Nanosponges for hydrogen evolution reaction: current trends and future perspectives

Rabiee,

Iravani

2023

Sustainable Energy Fuels

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“…The morphology of SARS-CoV-2 is shown in Figure 1. We must prioritize the development of rapid diagnostic testing, drug repurposing, and biomarkers of disease severity, as well as new platforms for vaccine production [12,13]. One of the most crucial considerations in vaccine development is the availability of platforms that can deliver the vaccine to specific sites in the human body without interfering with other functions [14].…”

Section: Introductionmentioning

confidence: 99%

Polymeric Nanoparticles (PNPs) as drug delivery systems for SARS-CoV-2

Adu,

Patel,

Catino

et al. 2024

Charact. Appl. Nanomater.

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Researchers from all over the world have been working tirelessly to combat the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) COVID-19 pandemic since the World Health Organization (WHO) proclaimed it to be a pandemic in 2019. Expanding testing capacities, creating efficient medications, and creating safe and efficient COVID-19 (SARS CoV-2) vaccinations that provide the human body with long-lasting protection are a few tactics that need to be investigated. In clinical studies, drug delivery techniques including nanoparticles have been used since the early 1990s. Since then, as technology has advanced and the need for improved medication delivery has increased, wherein the field of nanomedicine has recently seen significant development. PNPs, or polymeric nanoparticles, are solid particles or particulate dispersions that range in size from 10 to 1000 nm and their ability to efficiently deliver therapeutics to specific targets makes them ideal drug carriers. This review article discusses the many polymeric nanoparticle (PNP) platforms developed to counteract the recent COVID-19 pandemic-related severe acute respiratory syndrome coronavirus (SARS-CoV-2). The primary subjects of this article are the size, shape, cytotoxicity, and release mechanism of each nanoparticle. The two kinds of preparation methods in the synthesis of polymeric nanoparticles have been discussed: the first group uses premade polymers, while the other group depends on the direct polymerization of monomers. A few of the PNPs that have been utilized to combat previous viral outbreaks against SARS-CoV-2 are also covered.

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Nanosponges: An overlooked promising strategy to combat SARS-CoV-2

Cited by 9 publications

References 90 publications

Nanosponge hydrogel of octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate of Alcaligenes faecalis

Nanosponge hydrogel of octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate of Alcaligenes faecalis

Nanosponges for hydrogen evolution reaction: current trends and future perspectives

Polymeric Nanoparticles (PNPs) as drug delivery systems for SARS-CoV-2

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