Nanostructure Mediated Piezoelectric Effect of Tetragonal BaTiO3 Coatings on Bone Mesenchymal Stem Cell Shape and Osteogenic Differentiation

Zheng, Yafei; Zhao, Lei; Li, Ying; Zhang, Xinyuan; Zhang, Wei; Wang, Jing; Liu, Lipeng; An, Weikang; Jiao, Hua; Ma, Cheng

doi:10.3390/ijms24044051

Cited by 6 publications

(2 citation statements)

References 49 publications

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“…Beyond its role in electronics, energy harvesting, energy storage and biomedicine (e.g., [ 18 , 19 ]), barium titanate and its solid solutions present promising prospects as novel photocatalysts for efficiently removing hazardous organic pollutants from water and wastewater [ 20 ]. Recent developments have also extended their use in energy and environmental protection [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Spectroscopic Insight into Acceptor-Modified Barium Strontium Titanate Thin Films Deposited via the Sol–Gel Method

Czekaj,

Lisińska-Czekaj

2024

Materials

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In the present paper, composite thin films of barium strontium titanate (BaxSr1−xTiO3) with an acceptor modifier (magnesium oxide—MgO) were deposited on metal substrates (stainless steel type) using the sol–gel method. The composite thin films feature BaxSr1−xTiO3 ferroelectric solid solution as the matrix and MgO linear dielectric as the reinforcement, with MgO concentrations ranging from 1 to 5 mol%. Following thermal treatment at 650 °C, the films were analyzed for their impedance response. Experimental impedance spectra were modeled using the Kohlrausch–Williams–Watts function, revealing stretching parameters (β) in the range of approximately 0.78 to 0.89 and 0.56 to 0.90 for impedance and electric modulus formalisms, respectively. Notably, films modified with 3 mol% MgO exhibited the least stretched relaxation function. Employing the electric equivalent circuit method for data analysis, the “circle fit” analysis demonstrated an increase in capacitance from 2.97 × 10−12 F to 5.78 × 10−10 F with the incorporation of 3 mol% MgO into BST-based thin films. Further analysis based on Voigt, Maxwell, and ladder circuits revealed trends in resistance and capacitance components with varying MgO contents, suggesting non-Debye-type relaxation phenomena across all tested samples.

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Section: Introductionmentioning

confidence: 99%

Enhanced Spectroscopic Insight into Acceptor-Modified Barium Strontium Titanate Thin Films Deposited via the Sol–Gel Method

Czekaj,

Lisińska-Czekaj

2024

Materials

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“…Barium titanate nanoparticles (BaTiO3 NPs) are perovskite bioceramic materials and have been considered emerging nanomaterials due to their ferroelectricity and piezoelectric properties [3,6]. Notably, recent reports suggest that BaTiO3 NPs could be used in a wide range of applications including imaging diagnostics [7,8,] neural stimulation networks [9], drug nanocarriers [10], tissue engineering [11,12], and agribusiness [13].…”

Section: Introductionmentioning

confidence: 99%

Barium Titanate Nanoparticles Exhibit Cytocompatibility in Cultured Bovine Fibroblasts: A Model for Dermal Exposure

Onorato,

Amaral,

Oliveira

et al. 2024

CJAST

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The emergence of barium titanate nanoparticles (BaTiO3 NPs) represents an advancement in various fields such as technology, health, and agribusiness. However, increased production heightens the risk of their dispersion into the environment, thereby raising concerns about potential exposure to animals and humans, including the risk of dermal exposure. This study explores the chemical-physical properties of BaTiO3 NPs and their cytocompatibility using a bovine fibroblast cell model. The size and Zeta potential of the NPs were analyzed using scanning electron microscopy and dynamic light scattering technique. Raman spectroscopy was used to characterize the composition of the BaTiO3 NPs. Bovine fibroblasts were exposed in vitro to NPs (0.1 to 100 µg mL-1) for 24 hours to evaluate the cytocompatibility using the Thiazolyl Blue Tetrazolium Bromide assay and Trypan Blue exclusion test. The data were evaluated by analysis of variance and the means compared by the Tukey test. Scanning electron microscopy revealed that BaTiO3 NPs measured approximately 100 nm. Dynamic light scattering analysis indicated a hydrodynamic size of 149.27 nm with a polydispersion index of 0.37, and the Zeta potential was -13mV. Raman spectroscopy analysis highlighted the cubic phase of BaTiO3 NPs. Cytotoxicity tests demonstrated that BaTiO3 NPs did not affect cell viability, with 10 µg mL-1 resulting in enhanced cell proliferation. Overall, these findings underscore the non-toxic characteristics of BaTiO3 NPs in fibroblast cells, positioning them as promising and cytocompatible nanomaterials.

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Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

Chen,

Yang,

Cai

et al. 2024

Adv Funct Materials

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The incidence of large bone and articular cartilage defects caused by traumatic injury is increasing worldwide; the tissue regeneration process for these injuries is lengthy due to limited self‐healing ability. Endogenous bioelectrical phenomenon has been well recognized to play an important role in bone and cartilage homeostasis and regeneration. Studies have reported that electrical stimulation (ES) can effectively regulate various biological processes and holds promise as an external intervention to enhance the synthesis of the extracellular matrix, thereby accelerating the process of bone and cartilage regeneration. Hence, electroactive biomaterials have been considered a biomimetic approach to ensure functional recovery by integrating various physiological signals, including electrical, biochemical, and mechanical signals. This review will discuss the role of endogenous bioelectricity in bone and cartilage tissue, as well as the effects of ES on cellular behaviors. Then, recent advances in electroactive materials and their applications in bone and cartilage tissue regeneration are systematically overviewed, with a focus on their advantages and disadvantages as tissue repair materials and performances in the modulation of cell fate. Finally, the significance of mimicking the electrophysiological microenvironment of target tissue is emphasized and future development challenges of electroactive biomaterials for bone and cartilage repair strategies are proposed.

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Nanostructure Mediated Piezoelectric Effect of Tetragonal BaTiO3 Coatings on Bone Mesenchymal Stem Cell Shape and Osteogenic Differentiation

Cited by 6 publications

References 49 publications

Enhanced Spectroscopic Insight into Acceptor-Modified Barium Strontium Titanate Thin Films Deposited via the Sol–Gel Method

Enhanced Spectroscopic Insight into Acceptor-Modified Barium Strontium Titanate Thin Films Deposited via the Sol–Gel Method

Barium Titanate Nanoparticles Exhibit Cytocompatibility in Cultured Bovine Fibroblasts: A Model for Dermal Exposure

Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

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