Nanostructured biomaterials for regenerative medicine: Clinical perspectives

Zhang, Bin; Huang, Jie; Narayan, Roger J.

doi:10.1016/b978-0-08-102594-9.00003-6

Cited by 4 publications

(7 citation statements)

References 187 publications

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“…Another type of materials that can be utilized are bioceramics, such as HA and tricalcium phosphate (TCP), and bioglass. These are able to stimulate biomineralization for bone regeneration, and the biodegradability of calcium phosphate-based materials can be controlled by changing the calcium/phosphate ratio [ 75 , 95 , 96 ]. Scaffolds based on bioceramics are bioactive, fragile, and do not resist mechanical stresses.…”

Section: Tissue Engineering For Osteochondral Regenerationmentioning

confidence: 99%

“…Scaffolds based on bioceramics are bioactive, fragile, and do not resist mechanical stresses. However, they can be packed including natural or synthetic polymers aiming to improve their properties [ 75 , 96 , 97 ].…”

Section: Tissue Engineering For Osteochondral Regenerationmentioning

confidence: 99%

“…Nanoparticles of metals have been extensively studied due to their chemical, physical, and biological properties [ 96 , 98 ]. The unique characteristics of this type of materials are the atoms with high energy that are located in the surface area of the particles [ 99 ], the existence of a high relationship between surface area and volume, the high surface energy, and the capacity to store electrons [ 100 ].…”

Section: Tissue Engineering For Osteochondral Regenerationmentioning

confidence: 99%

“…Both can be considered good candidates for biomedical applications. Still, it is necessary to take into consideration their size, shape, stiffness, and surface properties, which are essential for their incorporation into cells [ 96 ].…”

Section: Tissue Engineering For Osteochondral Regenerationmentioning

confidence: 99%

See 3 more Smart Citations

Challenges and Innovations in Osteochondral Regeneration: Insights from Biology and Inputs from Bioengineering toward the Optimization of Tissue Engineering Strategies

Morouço

Fernandes

Lattanzi

2021

JFB

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Due to the extremely high incidence of lesions and diseases in aging population, it is critical to put all efforts into developing a successful implant for osteochondral tissue regeneration. Many of the patients undergoing surgery present osteochondral fissure extending until the subchondral bone (corresponding to a IV grade according to the conventional radiographic classification by Berndt and Harty). Therefore, strategies for functional tissue regeneration should also aim at healing the subchondral bone and joint interface, besides hyaline cartilage. With the ambition of contributing to solving this problem, several research groups have been working intensively on the development of tailored implants that could promote that complex osteochondral regeneration. These implants may be manufactured through a wide variety of processes and use a wide variety of (bio)materials. This review aimed to examine the state of the art regarding the challenges, advantages, and drawbacks of the current strategies for osteochondral regeneration. One of the most promising approaches relies on the principles of additive manufacturing, where technologies are used that allow for the production of complex 3D structures with a high level of control, intended and predefined geometry, size, and interconnected pores, in a reproducible way. However, not all materials are suitable for these processes, and their features should be examined, targeting a successful regeneration.

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Section: Tissue Engineering For Osteochondral Regenerationmentioning

confidence: 99%

Section: Tissue Engineering For Osteochondral Regenerationmentioning

confidence: 99%

Section: Tissue Engineering For Osteochondral Regenerationmentioning

confidence: 99%

Section: Tissue Engineering For Osteochondral Regenerationmentioning

confidence: 99%

See 2 more Smart Citations

Challenges and Innovations in Osteochondral Regeneration: Insights from Biology and Inputs from Bioengineering toward the Optimization of Tissue Engineering Strategies

Morouço

Fernandes

Lattanzi

2021

JFB

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“…Their mechanical integrity becomes important [102][103][104][105] when they are used as coating on tougher substrate [106][107][108]. The studies about coatings have proved that depending on the approach of coatings and deposition, the main chemical and physical characteristics will change [109][110][111][112][113]. It was understood that chemical properties like long-term stability can also affect the bioactive glass coating performance [82].…”

Section: Bioactive Glass Coatingmentioning

confidence: 99%

Bioactive Glass Coated Zirconia for Dental Implants: a review

Zhang

2020

jcc

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Nowadays, zirconia has got extensive attention for dental implants, although it has disadvantages such as poor mechanical properties and brittleness that makes it unsuitable. On the other hand, bioactive glasses coating have been utilized on tougher substrates such as zirconia. Bioactive glass coatings can decrease the healing time and hence accelerate the formation of the bond between bone and implant. Hence in this study, we introduce the novel zirconia/bioactive glass composites with high mechanical strength and bioactivity to achieve the ideal implant dentistry. Furthermore, a review of bioactive glass coatings (i.e., 45S5 and 58S) on zirconia as well as surface modification methods (i.e., sol-gel, laser cladding, plasma spraying, etc.) is provided.

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Biomaterials for Cell Regeneration

Kumar¹

2021

Materials Research Foundations

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Biomaterial sciences approaches are as of now crucial systems for the improvement of regenerative cell and medication. Present day material advances take into consideration the improvement of inventive biomaterials that nearly compare to prerequisites of the current biomedical application. A few biomaterials helpful for unmistakable applications in restorative sciences, incorporating into tissue repair and organ reproduction. Natural materials for example, agarose, collagen, alginate, chitosan or fibrin completely coordinate with living tissues of the beneficiary and have low cytotoxicity. Biomaterials, for example, ceramics and metals, are now utilized as inserts to supplant or enhance the usefulness of the harmed tissue or organ. Additionally, the constant advancement of present day innovation opens new experiences of polymeric and smart material applications. Biomaterials may improve the immature microorganisms organic movement and their usage by setting up an explicit microenvironment emulating characteristic cell specialty.

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Nanostructured biomaterials for regenerative medicine: Clinical perspectives

Cited by 4 publications

References 187 publications

Challenges and Innovations in Osteochondral Regeneration: Insights from Biology and Inputs from Bioengineering toward the Optimization of Tissue Engineering Strategies

Challenges and Innovations in Osteochondral Regeneration: Insights from Biology and Inputs from Bioengineering toward the Optimization of Tissue Engineering Strategies

Bioactive Glass Coated Zirconia for Dental Implants: a review

Biomaterials for Cell Regeneration

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