Antibiotics are commonly using for killing of human and animal host pathogenic fungi and bacteria. It was reported that annual global consumption of antibiotics is ranging between 100 hundred thousand to 200 hundred thousand tones. Therefore, the aquatic system is carrying such kind of toxicants and consequent severe impact on human health and other biotic components in the ecosystem. Therefore, water system containing antibiotics is gained to attention of decontamination by appropriate technology. The adsorption process is a popular technique having easy operation, economically convenient, wide selectivity, significant efficiency for decontamination of antibiotics. Among other adsorbents, the aerogels are reported as low cost with excellent properties including high porosity, low density, extended surface area (108–539 m 2 g −1 ), biocompatibility and biodegradability etc. The aimed of this review was to evaluate the modification routes, adsorption efficiency and mechanistic insight of adsorption mechanisms of antibiotics were explored by reported studies.