Nanostructured Boron Nitride With High Water Dispersibility For Boron Neutron Capture Therapy

Abstract

Highly water dispersible boron based compounds are innovative and advanced materials which can be used in Boron Neutron Capture Therapy for cancer treatment (BNCT). Present study deals with the synthesis of highly water dispersible nanostructured Boron Nitride (BN). Unique and relatively low temperature synthesis route is the soul of present study. The morphological examinations (Scanning/transmission electron microscopy) of synthesized nanostructures showed that they are in transient phase from two dimensional hexagonal sheets to nanotubes. It is also supported by dual energy band gap of these materials calculated from UV- visible spectrum of the material. The theoretically calculated band gap also supports the same (calculated by virtual nano lab Software). X-ray diffraction (XRD) analysis shows that the synthesized material has deformed structure which is further supported by Raman spectroscopy. The structural aspect of high water disperse ability of BN is also studied. The ultra-high disperse ability which is a result of structural deformation make these nanostructures very useful in BNCT. Cytotoxicity studies on various cell lines (Hela(cervical cancer), human embryonic kidney (HEK-293) and human breast adenocarcinoma (MCF-7)) show that the synthesized nanostructures can be used for BNCT.

Application of Chemically Exfoliated Boron Nitride Nanosheets Doped with Co to Remove Organic Pollutants Rapidly from Textile Water

“…Furthermore, peaks at 1020, 1160, and 1672 cm −1 were consistent with C-O, B-N-O, and C=O bond, respectively [44]. Another peak centered at 3187 cm −1 corresponds to the B-OH bond [45,46].…”

Vibrational Spectroscopy of Water with High Spatial Resolution

“…It is notable that the OH peak at 400 nmeV is offset from the expected energy of ≈420 meV, while the OD peak clearly matches its expected value. A wide band of NH and NH 2 stretching modes has been recorded in the energy range between 372 and 409 meV using monochromated EELS and in optical spectroscopy and there is a possibility that some NH x , with a resonance of ≈400 meV, has adsorbed on the BN surface during the sample preparation . However, we expect this effect to be very small due to its low concentration with respect to water.…”

Hexagonal Boron Nitride Functionalized with Au Nanoparticles—Properties and Potential Biological Applications

“…Singh and co-workers [ 51 ] tested the biocompatibility of boron nitride in the context of Boron Neutron Therapy (BNCT). The nanostructured BN was added to various cell line cultures: HeLa, HEK-293 and MCF-7 in the concentration range of 0.25–1.0 mg mL −1 and incubated for 24 and 48 h to determine the cellular response.…”

“…Cell survival rate was the lowest after 48-h incubation and reached 40% for MCF-7 and 30% for HeLa cells at the 2 mg mL −1 concentration. HEK-293 cells exhibited by 50% higher survival rate during 48-h incubation and by 70% during 24-h exposure at 2 mg mL −1 concentration, thus Singh et al [ 51 ] concluded that the cytotoxicity of BN nanostructures was higher for cancerous cells in comparison with normal cell lines [ 50 ]. Singh et al [ 51 ] suggested that a higher membrane pore size might be responsible for the enhanced uptake of BN, which led to a higher cytotoxicity, but these conclusions were not validated and need to be evaluated in further investigations [ 51 ].…”